FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148915854> ?p ?o ?g. }

• W2148915854 endingPage "11460" @default.
• W2148915854 startingPage "11452" @default.
• W2148915854 abstract "ABSTRACT Ebola virus VP40 is able to produce virus-like particles (VLPs) in the absence of other viral proteins. At least three domains within VP40 are thought to be required for efficient VLP release: the late domain (L-domain), membrane association domain (M-domain), and self-interaction domain (I-domain). While the L-domain of Ebola VP40 has been well characterized, the exact mechanism by which VP40 mediates budding through the M- and I-domains remains unclear. To identify additional domains important for VP40 assembly/budding, amino acids 212 KLR 214 were targeted for mutagenesis based on the published crystal structure of VP40. These residues are part of a loop connecting two beta sheets in the C-terminal region and thus are potentially important for overall structure and/or oligomerization of VP40. A series of alanine substitutions were generated in the KLR region of VP40, and these mutants were examined for VLP budding, intracellular localization, and oligomerization. Our results indicated that (i) 212 KLR 214 residues of VP40 are important for efficient release of VP40 VLPs, with Leu213 being the most critical; (ii) VP40 KLR mutants displayed altered patterns of cellular localization compared to that of wild-type VP40 (VP40-WT); and (iii) self-assembly of VP40 KLR mutants into oligomers was altered compared to that of VP40-WT. These results suggest that 12 KLR 214 residues of VP40 are important for proper assembly/oligomerization of VP40 which subsequently leads to efficient budding of VLPs." @default.
• W2148915854 created "2016-06-24" @default.
• W2148915854 creator A5011254550 @default.
• W2148915854 creator A5063601670 @default.
• W2148915854 creator A5074666258 @default.
• W2148915854 creator A5077162460 @default.
• W2148915854 creator A5083527243 @default.
• W2148915854 date "2007-10-15" @default.
• W2148915854 modified "2023-09-27" @default.
• W2148915854 title "Role for Amino Acids ₂₁₂ KLR ₂₁₄ of Ebola Virus VP40 in Assembly and Budding" @default.
• W2148915854 cites W1965095658 @default.
• W2148915854 cites W1983445366 @default.
• W2148915854 cites W1995387813 @default.
• W2148915854 cites W1997094608 @default.
• W2148915854 cites W2006546036 @default.
• W2148915854 cites W2008316672 @default.
• W2148915854 cites W2016838605 @default.
• W2148915854 cites W2022595858 @default.
• W2148915854 cites W2022719897 @default.
• W2148915854 cites W2026488805 @default.
• W2148915854 cites W2029169661 @default.
• W2148915854 cites W2041902881 @default.
• W2148915854 cites W2042182707 @default.
• W2148915854 cites W2050499016 @default.
• W2148915854 cites W2066254201 @default.
• W2148915854 cites W2071607445 @default.
• W2148915854 cites W2071967966 @default.
• W2148915854 cites W2075462958 @default.
• W2148915854 cites W2078972358 @default.
• W2148915854 cites W2096284021 @default.
• W2148915854 cites W2102537321 @default.
• W2148915854 cites W2118436036 @default.
• W2148915854 cites W2128782078 @default.
• W2148915854 cites W2156633263 @default.
• W2148915854 cites W2160796054 @default.
• W2148915854 cites W2170665473 @default.
• W2148915854 cites W2171864254 @default.
• W2148915854 cites W4231619280 @default.
• W2148915854 doi "https://doi.org/10.1128/jvi.00853-07" @default.
• W2148915854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2045517" @default.
• W2148915854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17699576" @default.
• W2148915854 hasPublicationYear "2007" @default.
• W2148915854 type Work @default.
• W2148915854 sameAs 2148915854 @default.
• W2148915854 citedByCount "38" @default.
• W2148915854 countsByYear W21489158542012 @default.
• W2148915854 countsByYear W21489158542013 @default.
• W2148915854 countsByYear W21489158542014 @default.
• W2148915854 countsByYear W21489158542015 @default.
• W2148915854 countsByYear W21489158542016 @default.
• W2148915854 countsByYear W21489158542017 @default.
• W2148915854 countsByYear W21489158542019 @default.
• W2148915854 countsByYear W21489158542020 @default.
• W2148915854 countsByYear W21489158542021 @default.
• W2148915854 crossrefType "journal-article" @default.
• W2148915854 hasAuthorship W2148915854A5011254550 @default.
• W2148915854 hasAuthorship W2148915854A5063601670 @default.
• W2148915854 hasAuthorship W2148915854A5074666258 @default.
• W2148915854 hasAuthorship W2148915854A5077162460 @default.
• W2148915854 hasAuthorship W2148915854A5083527243 @default.
• W2148915854 hasBestOaLocation W21489158541 @default.
• W2148915854 hasConcept C104317684 @default.
• W2148915854 hasConcept C143065580 @default.
• W2148915854 hasConcept C144292202 @default.
• W2148915854 hasConcept C159047783 @default.
• W2148915854 hasConcept C198410946 @default.
• W2148915854 hasConcept C2522874641 @default.
• W2148915854 hasConcept C2777469322 @default.
• W2148915854 hasConcept C515207424 @default.
• W2148915854 hasConcept C55493867 @default.
• W2148915854 hasConcept C57711820 @default.
• W2148915854 hasConcept C86295872 @default.
• W2148915854 hasConcept C86803240 @default.
• W2148915854 hasConcept C95444343 @default.
• W2148915854 hasConceptScore W2148915854C104317684 @default.
• W2148915854 hasConceptScore W2148915854C143065580 @default.
• W2148915854 hasConceptScore W2148915854C144292202 @default.
• W2148915854 hasConceptScore W2148915854C159047783 @default.
• W2148915854 hasConceptScore W2148915854C198410946 @default.
• W2148915854 hasConceptScore W2148915854C2522874641 @default.
• W2148915854 hasConceptScore W2148915854C2777469322 @default.
• W2148915854 hasConceptScore W2148915854C515207424 @default.
• W2148915854 hasConceptScore W2148915854C55493867 @default.
• W2148915854 hasConceptScore W2148915854C57711820 @default.
• W2148915854 hasConceptScore W2148915854C86295872 @default.
• W2148915854 hasConceptScore W2148915854C86803240 @default.
• W2148915854 hasConceptScore W2148915854C95444343 @default.
• W2148915854 hasIssue "20" @default.
• W2148915854 hasLocation W21489158541 @default.
• W2148915854 hasLocation W21489158542 @default.
• W2148915854 hasLocation W21489158543 @default.
• W2148915854 hasLocation W21489158544 @default.
• W2148915854 hasOpenAccess W2148915854 @default.
• W2148915854 hasPrimaryLocation W21489158541 @default.
• W2148915854 hasRelatedWork W1989133172 @default.
• W2148915854 hasRelatedWork W1993296305 @default.
• W2148915854 hasRelatedWork W2118436036 @default.
• W2148915854 hasRelatedWork W2128782078 @default.

• next