FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148937110> ?p ?o ?g. }

• W2148937110 endingPage "723" @default.
• W2148937110 startingPage "712" @default.
• W2148937110 abstract "Summary Shedding of microvesicles (MVs) by cancer cells is implicated in a variety of biological effects, including the establishment of cancer-associated hypercoagulable states. However, the mechanisms underlying malignant transformation and the acquisition of procoagulant properties by tumour-derived MVs are poorly understood. Here we investigated the procoagulant and prothrombotic properties of MVs produced by a melanocyte-derived cell line (melan-a) as compared to its tumourigenic melanoma counterpart Tm1. Tumour cells exhibit a two-fold higher rate of MVs production as compared to melan-a. Melanoma MVs display greater procoagulant activity and elevated levels of the clotting initiator protein tissue factor (TF). On the other hand, tumour- and melanocyte- derived MVs expose similar levels of the procoagulant lipid phosphatidylserine, displaying identical abilities to support thrombin generation by the prothrombinase complex. By using an arterial thrombosis model, we observed that melanoma- but not melanocyte-derived MVs strongly accelerate thrombus formation in a TF-dependent manner, and accumulate at the site of vascular injury. Analysis of plasma obtained from melanoma-bearing mice showed the presence of MVs with a similar procoagulant pattern as compared to Tm1 MVs produced in vitro. Remarkably, flow-cytometric analysis demonstrated that 60% of ex vivo MVs are TF-positive and carry the melanoma-associated antigen, demonstrating its tumour origin. Altogether our data suggest that malignant transformation in melanocytes increases the production of procoagulant MVs, which may contribute for a variety of coagulation- related protumoural responses." @default.
• W2148937110 created "2016-06-24" @default.
• W2148937110 creator A5021344703 @default.
• W2148937110 creator A5028177987 @default.
• W2148937110 creator A5030033257 @default.
• W2148937110 creator A5036565811 @default.
• W2148937110 creator A5056362500 @default.
• W2148937110 creator A5056811898 @default.
• W2148937110 creator A5056833266 @default.
• W2148937110 creator A5062413979 @default.
• W2148937110 creator A5075617174 @default.
• W2148937110 creator A5083692113 @default.
• W2148937110 date "2011-01-01" @default.
• W2148937110 modified "2023-09-27" @default.
• W2148937110 title "Malignant transformation in melanocytes is associated with increased production of procoagulant microvesicles" @default.
• W2148937110 cites W142608924 @default.
• W2148937110 cites W165853039 @default.
• W2148937110 cites W1693284829 @default.
• W2148937110 cites W1964232997 @default.
• W2148937110 cites W1964473451 @default.
• W2148937110 cites W1969259882 @default.
• W2148937110 cites W1972070926 @default.
• W2148937110 cites W1972331749 @default.
• W2148937110 cites W1992160817 @default.
• W2148937110 cites W1993459732 @default.
• W2148937110 cites W1994861753 @default.
• W2148937110 cites W1995472148 @default.
• W2148937110 cites W1998106433 @default.
• W2148937110 cites W2000808749 @default.
• W2148937110 cites W2002728088 @default.
• W2148937110 cites W2003714769 @default.
• W2148937110 cites W2008409796 @default.
• W2148937110 cites W2012535096 @default.
• W2148937110 cites W2015962018 @default.
• W2148937110 cites W2019573005 @default.
• W2148937110 cites W2030701238 @default.
• W2148937110 cites W2032860439 @default.
• W2148937110 cites W2036999916 @default.
• W2148937110 cites W2038479057 @default.
• W2148937110 cites W2046783628 @default.
• W2148937110 cites W2049657352 @default.
• W2148937110 cites W2050696595 @default.
• W2148937110 cites W2051959397 @default.
• W2148937110 cites W2055792439 @default.
• W2148937110 cites W2059215414 @default.
• W2148937110 cites W2066541045 @default.
• W2148937110 cites W2066763853 @default.
• W2148937110 cites W2074892413 @default.
• W2148937110 cites W2077049963 @default.
• W2148937110 cites W2083079937 @default.
• W2148937110 cites W2083178439 @default.
• W2148937110 cites W2084743097 @default.
• W2148937110 cites W2087008556 @default.
• W2148937110 cites W2087429704 @default.
• W2148937110 cites W2090903207 @default.
• W2148937110 cites W2096124900 @default.
• W2148937110 cites W2101185555 @default.
• W2148937110 cites W2134118188 @default.
• W2148937110 cites W2144186245 @default.
• W2148937110 cites W2154344198 @default.
• W2148937110 cites W2157603089 @default.
• W2148937110 cites W2163777386 @default.
• W2148937110 cites W2170571560 @default.
• W2148937110 cites W2332736166 @default.
• W2148937110 cites W4230178784 @default.
• W2148937110 cites W4240067294 @default.
• W2148937110 doi "https://doi.org/10.1160/th11-03-0143" @default.
• W2148937110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21800005" @default.
• W2148937110 hasPublicationYear "2011" @default.
• W2148937110 type Work @default.
• W2148937110 sameAs 2148937110 @default.
• W2148937110 citedByCount "46" @default.
• W2148937110 countsByYear W21489371102012 @default.
• W2148937110 countsByYear W21489371102013 @default.
• W2148937110 countsByYear W21489371102014 @default.
• W2148937110 countsByYear W21489371102015 @default.
• W2148937110 countsByYear W21489371102016 @default.
• W2148937110 countsByYear W21489371102017 @default.
• W2148937110 countsByYear W21489371102018 @default.
• W2148937110 countsByYear W21489371102019 @default.
• W2148937110 countsByYear W21489371102020 @default.
• W2148937110 countsByYear W21489371102021 @default.
• W2148937110 countsByYear W21489371102022 @default.
• W2148937110 countsByYear W21489371102023 @default.
• W2148937110 crossrefType "journal-article" @default.
• W2148937110 hasAuthorship W2148937110A5021344703 @default.
• W2148937110 hasAuthorship W2148937110A5028177987 @default.
• W2148937110 hasAuthorship W2148937110A5030033257 @default.
• W2148937110 hasAuthorship W2148937110A5036565811 @default.
• W2148937110 hasAuthorship W2148937110A5056362500 @default.
• W2148937110 hasAuthorship W2148937110A5056811898 @default.
• W2148937110 hasAuthorship W2148937110A5056833266 @default.
• W2148937110 hasAuthorship W2148937110A5062413979 @default.
• W2148937110 hasAuthorship W2148937110A5075617174 @default.
• W2148937110 hasAuthorship W2148937110A5083692113 @default.
• W2148937110 hasConcept C104317684 @default.
• W2148937110 hasConcept C112516734 @default.
• W2148937110 hasConcept C126322002 @default.

• next