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• W2148953670 abstract "The purpose of this investigation was to evaluate the pulmonary clearance rate of 99m technetium-diethylenetriaminepentaacetic acid ( 99m Tc-DTPA) through the use of continuous positive airway pressure (CPAP) in different postures. It was a quasi-experimental study involving 36 healthy individuals with normal spirometry. 99m Tc-DTPA, as aerosol, was nebulized for 3 min with the individual in a sitting position. The pulmonary clearance rate was assessed through pulmonary scintigraphy under spontaneous breathing and under 20 and 10 cmH 2 O CPAP in the sitting and supine positions. The clearance rate was expressed as the half-time (T 1/2 ), that is, the time for the activity to decrease to 50% of the peak value. 20 cmH 2 O CPAP produced significant reduction of the T 1/2 of 99m Tc-DTPA in the supine position (P = 0.009) and in the sitting position (P = 0.005). However, 10 cmH 2 O CPAP did not alter the T 1/2 of DTPA in both positions. The postural variation from supine to the sitting position with 10 cmH 2 O CPAP (P = 0.01) and 20 cmH 2 O (P = 0.02) also reduced the T 1/2 of 99m Tc-DTPA. High levels of positive pressure in normal lungs resulted in faster 99m Tc-DTPA clearance. Moreover, the sitting position further increased the clearance rate of the 99mTc radioaerosol imaging in the two pressure levels studied. Key words: Continuous positive airway pressure, 99m Tc-DTPA, scintigraphy, posture." @default.
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• W2148953670 date "2012-12-11" @default.
• W2148953670 modified "2023-10-17" @default.
• W2148953670 title "Continuous positive airway pressure and body position alter lung clearance of the radiopharmaceutical 99mtechnetium-diethylenetriaminepentaacetic acid (99mTc-DTPA)" @default.
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• W2148953670 doi "https://doi.org/10.5897/ajb12.2563" @default.
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