FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148959652> ?p ?o ?g. }

• W2148959652 endingPage "56" @default.
• W2148959652 startingPage "45" @default.
• W2148959652 abstract "Microglia polarization to the classical M1 activation state is characterized by elevated pro-inflammatory cytokines; however, a full profile has not been generated in the early stages of a sterile inflammatory response recruiting only resident microglia. We characterized the initial M1 state in a hippocampal injury model dependent upon tumor necrosis factor (TNF) receptor signaling for dentate granule cell death. Twenty-one-day-old CD1 male mice were injected with trimethyltin (TMT 2.3 mg/kg, i.p.) and the hippocampus was examined at an early stage (24-h post-dosing) of neuronal death. Glia activation was assessed using a custom quantitative nuclease protection assay. We report elevated mRNA levels for glia response such as ionizing calcium-binding adapter molecule-1 and glial fibrillary acidic protein (Gfap); Fas, hypoxia inducible factor alpha, complement component 1qb, TNF-related genes (Tnf, Tnfaip3, Tnfrsfla); interleukin-1 alpha, Cd44, chemokine (C-C motif) ligand (Ccl)2, Cc14, integrin alpha M, lipocalin (Lcn2), and secreted phosphoprotein 1 (Spp1). These changes occurred in the absence of changes in matrix metalloproteinase 9 and 12, neural cell adhesion molecule, metabotropic glutamate receptor (Grm)3, and Ly6/neurotoxin 1 (Lynx1), as well as, a decrease in neurotrophin 3, glutamate receptor subunit epsilon (Grin)-2b, and neurotrophic tyrosine kinase receptor, type 3. The M2 anti-inflammatory marker, transforming growth factor beta-1 (Tgfb1) was elevated. mRNAs associated with early stage of injury-induced neurogenesis including fibroblast growth factor 21 and Mki67 were elevated. In the non-injured temporal cortex receiving projections from the hippocampus, Lynx1, Grm3, and Grin2b were decreased and Gfap increased. Formalin fixed-paraffin-embedded tissue did not generate a comparable profile." @default.
• W2148959652 created "2016-06-24" @default.
• W2148959652 creator A5011792363 @default.
• W2148959652 creator A5060834868 @default.
• W2148959652 creator A5088686533 @default.
• W2148959652 date "2013-09-04" @default.
• W2148959652 modified "2023-09-27" @default.
• W2148959652 title "In Vivo Molecular Markers for Pro-inflammatory Cytokine M1 Stage and Resident Microglia in Trimethyltin-Induced Hippocampal Injury" @default.
• W2148959652 cites W1507360146 @default.
• W2148959652 cites W1966246536 @default.
• W2148959652 cites W1966311101 @default.
• W2148959652 cites W1968053635 @default.
• W2148959652 cites W1968615956 @default.
• W2148959652 cites W1973122948 @default.
• W2148959652 cites W1973886691 @default.
• W2148959652 cites W1975111111 @default.
• W2148959652 cites W1977213877 @default.
• W2148959652 cites W1979099111 @default.
• W2148959652 cites W1991805788 @default.
• W2148959652 cites W1993278698 @default.
• W2148959652 cites W1994144722 @default.
• W2148959652 cites W1995458780 @default.
• W2148959652 cites W1998040264 @default.
• W2148959652 cites W2000918690 @default.
• W2148959652 cites W2004974370 @default.
• W2148959652 cites W2006653606 @default.
• W2148959652 cites W2007374837 @default.
• W2148959652 cites W2010037905 @default.
• W2148959652 cites W2010915352 @default.
• W2148959652 cites W2013874197 @default.
• W2148959652 cites W2020142342 @default.
• W2148959652 cites W2020750200 @default.
• W2148959652 cites W2023572776 @default.
• W2148959652 cites W2036292064 @default.
• W2148959652 cites W2042851093 @default.
• W2148959652 cites W2043020388 @default.
• W2148959652 cites W204348490 @default.
• W2148959652 cites W2046607296 @default.
• W2148959652 cites W2049308389 @default.
• W2148959652 cites W2050753211 @default.
• W2148959652 cites W2054792363 @default.
• W2148959652 cites W2055885996 @default.
• W2148959652 cites W2058632165 @default.
• W2148959652 cites W2061254730 @default.
• W2148959652 cites W2067267561 @default.
• W2148959652 cites W2074808874 @default.
• W2148959652 cites W2076455662 @default.
• W2148959652 cites W2081810944 @default.
• W2148959652 cites W2082313538 @default.
• W2148959652 cites W2083048654 @default.
• W2148959652 cites W2085424855 @default.
• W2148959652 cites W2086236919 @default.
• W2148959652 cites W2087053296 @default.
• W2148959652 cites W2087079891 @default.
• W2148959652 cites W2087219301 @default.
• W2148959652 cites W2091575564 @default.
• W2148959652 cites W2095444837 @default.
• W2148959652 cites W2101898118 @default.
• W2148959652 cites W2108435419 @default.
• W2148959652 cites W2109759840 @default.
• W2148959652 cites W2116008939 @default.
• W2148959652 cites W2121438383 @default.
• W2148959652 cites W2122561878 @default.
• W2148959652 cites W2124085296 @default.
• W2148959652 cites W2129492437 @default.
• W2148959652 cites W2134729461 @default.
• W2148959652 cites W2136123169 @default.
• W2148959652 cites W2156215288 @default.
• W2148959652 cites W2160881152 @default.
• W2148959652 cites W2161456562 @default.
• W2148959652 cites W2162325038 @default.
• W2148959652 cites W2168114040 @default.
• W2148959652 cites W2170959966 @default.
• W2148959652 cites W2171549018 @default.
• W2148959652 cites W2279930917 @default.
• W2148959652 cites W3164819891 @default.
• W2148959652 doi "https://doi.org/10.1007/s12640-013-9422-3" @default.
• W2148959652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3880630" @default.
• W2148959652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24002884" @default.
• W2148959652 hasPublicationYear "2013" @default.
• W2148959652 type Work @default.
• W2148959652 sameAs 2148959652 @default.
• W2148959652 citedByCount "31" @default.
• W2148959652 countsByYear W21489596522014 @default.
• W2148959652 countsByYear W21489596522015 @default.
• W2148959652 countsByYear W21489596522016 @default.
• W2148959652 countsByYear W21489596522018 @default.
• W2148959652 countsByYear W21489596522019 @default.
• W2148959652 countsByYear W21489596522020 @default.
• W2148959652 countsByYear W21489596522021 @default.
• W2148959652 countsByYear W21489596522022 @default.
• W2148959652 countsByYear W21489596522023 @default.
• W2148959652 crossrefType "journal-article" @default.
• W2148959652 hasAuthorship W2148959652A5011792363 @default.
• W2148959652 hasAuthorship W2148959652A5060834868 @default.
• W2148959652 hasAuthorship W2148959652A5088686533 @default.
• W2148959652 hasBestOaLocation W21489596522 @default.
• W2148959652 hasConcept C134018914 @default.

• next