FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148963522> ?p ?o ?g. }

• W2148963522 endingPage "C1030" @default.
• W2148963522 startingPage "C1018" @default.
• W2148963522 abstract "Conditioned media from the probiotic Lactobacillus GG (LGG-CM) induce heat shock protein (Hsp) expression in intestinal epithelial cells. LGG-CM induces both Hsp25 and Hsp72 in a time- and concentration-dependent manner. These effects are mediated by a low-molecular-weight peptide that is acid and heat stable. DNA microarray experiments demonstrate that Hsp72 is one of the most highly upregulated genes in response to LGG-CM treatment. Real-time PCR and electrophoretic mobility shift assay confirm that regulation of Hsp induction is at least in part transcriptional in nature, involving heat shock factor-1. Although Hsps are not induced for hours after exposure, transient exposure to LGG-CM is sufficient to initiate the signal for Hsp induction, suggesting that signal transduction pathways may be involved. Experiments confirm that LGG-CM modulates the activity of certain signaling pathways in intestinal epithelial cells by activating MAP kinases. Inhibitors of p38 and JNK block the expression of Hsp72 normally induced by LGG-CM. Functional studies indicate that LGG-CM treatment of gut epithelial cells protects them from oxidant stress, perhaps by preserving cytoskeletal integrity. By inducing the expression of cytoprotective Hsps in gut epithelial cells, and by activating signal transduction pathways, the peptide product(s) secreted by LGG may contribute to the beneficial clinical effects attributed to this probiotic." @default.
• W2148963522 created "2016-06-24" @default.
• W2148963522 creator A5002418171 @default.
• W2148963522 creator A5015271282 @default.
• W2148963522 creator A5031563441 @default.
• W2148963522 creator A5042231260 @default.
• W2148963522 creator A5054659802 @default.
• W2148963522 creator A5064316894 @default.
• W2148963522 creator A5070755696 @default.
• W2148963522 creator A5083683183 @default.
• W2148963522 date "2006-04-01" @default.
• W2148963522 modified "2023-10-03" @default.
• W2148963522 title "Soluble factors from<i>Lactobacillus GG</i>activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells" @default.
• W2148963522 cites W1770841622 @default.
• W2148963522 cites W1880052201 @default.
• W2148963522 cites W1892225881 @default.
• W2148963522 cites W1961388096 @default.
• W2148963522 cites W1974424681 @default.
• W2148963522 cites W1988439456 @default.
• W2148963522 cites W1990692531 @default.
• W2148963522 cites W1997149916 @default.
• W2148963522 cites W1997265343 @default.
• W2148963522 cites W2000439316 @default.
• W2148963522 cites W2005441308 @default.
• W2148963522 cites W2009296652 @default.
• W2148963522 cites W2010112736 @default.
• W2148963522 cites W2012349147 @default.
• W2148963522 cites W2013164318 @default.
• W2148963522 cites W2014835001 @default.
• W2148963522 cites W2015471917 @default.
• W2148963522 cites W2017086844 @default.
• W2148963522 cites W2019872821 @default.
• W2148963522 cites W2036179712 @default.
• W2148963522 cites W2038437697 @default.
• W2148963522 cites W2054872303 @default.
• W2148963522 cites W2070909432 @default.
• W2148963522 cites W2072646880 @default.
• W2148963522 cites W2077672936 @default.
• W2148963522 cites W2084810788 @default.
• W2148963522 cites W2093155471 @default.
• W2148963522 cites W2094597611 @default.
• W2148963522 cites W2104684779 @default.
• W2148963522 cites W2115284864 @default.
• W2148963522 cites W2119685559 @default.
• W2148963522 cites W2122314247 @default.
• W2148963522 cites W2125718337 @default.
• W2148963522 cites W2127400149 @default.
• W2148963522 cites W2127805721 @default.
• W2148963522 cites W2135402896 @default.
• W2148963522 cites W2139759128 @default.
• W2148963522 cites W2141542812 @default.
• W2148963522 cites W2143889006 @default.
• W2148963522 cites W2144082513 @default.
• W2148963522 cites W2147201050 @default.
• W2148963522 cites W2148573587 @default.
• W2148963522 cites W2155138686 @default.
• W2148963522 cites W2158718550 @default.
• W2148963522 cites W2160151699 @default.
• W2148963522 cites W2163318854 @default.
• W2148963522 cites W2171045296 @default.
• W2148963522 cites W2269326075 @default.
• W2148963522 cites W2409937641 @default.
• W2148963522 cites W4232534952 @default.
• W2148963522 doi "https://doi.org/10.1152/ajpcell.00131.2005" @default.
• W2148963522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16306130" @default.
• W2148963522 hasPublicationYear "2006" @default.
• W2148963522 type Work @default.
• W2148963522 sameAs 2148963522 @default.
• W2148963522 citedByCount "274" @default.
• W2148963522 countsByYear W21489635222012 @default.
• W2148963522 countsByYear W21489635222013 @default.
• W2148963522 countsByYear W21489635222014 @default.
• W2148963522 countsByYear W21489635222015 @default.
• W2148963522 countsByYear W21489635222016 @default.
• W2148963522 countsByYear W21489635222017 @default.
• W2148963522 countsByYear W21489635222018 @default.
• W2148963522 countsByYear W21489635222019 @default.
• W2148963522 countsByYear W21489635222020 @default.
• W2148963522 countsByYear W21489635222021 @default.
• W2148963522 countsByYear W21489635222022 @default.
• W2148963522 countsByYear W21489635222023 @default.
• W2148963522 crossrefType "journal-article" @default.
• W2148963522 hasAuthorship W2148963522A5002418171 @default.
• W2148963522 hasAuthorship W2148963522A5015271282 @default.
• W2148963522 hasAuthorship W2148963522A5031563441 @default.
• W2148963522 hasAuthorship W2148963522A5042231260 @default.
• W2148963522 hasAuthorship W2148963522A5054659802 @default.
• W2148963522 hasAuthorship W2148963522A5064316894 @default.
• W2148963522 hasAuthorship W2148963522A5070755696 @default.
• W2148963522 hasAuthorship W2148963522A5083683183 @default.
• W2148963522 hasConcept C104317684 @default.
• W2148963522 hasConcept C127561419 @default.
• W2148963522 hasConcept C132149769 @default.
• W2148963522 hasConcept C137984847 @default.
• W2148963522 hasConcept C153911025 @default.
• W2148963522 hasConcept C185592680 @default.
• W2148963522 hasConcept C205260736 @default.
• W2148963522 hasConcept C2779559962 @default.

• next