FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148964182> ?p ?o ?g. }

• W2148964182 endingPage "748" @default.
• W2148964182 startingPage "740" @default.
• W2148964182 abstract "Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking-related health outcomes. Previous studies have typically relied on self-reported smoking behavior, which may not fully capture interindividual variation in tobacco exposure.We investigated the association of rs1051730 and rs16969968 genotype (referred to as rs1051730-rs16969968, because these are in perfect linkage disequilibrium and interchangeable) with both self-reported daily cigarette consumption and biochemically measured plasma or serum cotinine levels among cigarette smokers. Summary estimates and descriptive statistical data for 12 364 subjects were obtained from six independent studies, and 2932 smokers were included in the analyses. Linear regression was used to calculate the per-allele association of rs1051730-rs16969968 genotype with cigarette consumption and cotinine levels in current smokers for each study. Meta-analysis of per-allele associations was conducted using a random effects method. The likely resulting association between genotype and lung cancer risk was assessed using published data on the association between cotinine levels and lung cancer risk. All statistical tests were two-sided.Pooled per-allele associations showed that current smokers with one or two copies of the rs1051730-rs16969968 risk allele had increased self-reported cigarette consumption (mean increase in unadjusted number of cigarettes per day per allele = 1.0 cigarette, 95% confidence interval [CI] = 0.57 to 1.43 cigarettes, P = 5.22 × 10(-6)) and cotinine levels (mean increase in unadjusted cotinine levels per allele = 138.72 nmol/L, 95% CI = 97.91 to 179.53 nmol/L, P = 2.71 × 10(-11)). The increase in cotinine levels indicated an increased risk of lung cancer with each additional copy of the rs1051730-rs16969968 risk allele (per-allele odds ratio = 1.31, 95% CI = 1.21 to 1.42).Our data show a stronger association of rs1051730-rs16969968 genotype with objective measures of tobacco exposure compared with self-reported cigarette consumption. The association of these variants with lung cancer risk is likely to be mediated largely, if not wholly, via tobacco exposure." @default.
• W2148964182 created "2016-06-24" @default.
• W2148964182 creator A5003281111 @default.
• W2148964182 creator A5003345820 @default.
• W2148964182 creator A5006758334 @default.
• W2148964182 creator A5013184354 @default.
• W2148964182 creator A5013599374 @default.
• W2148964182 creator A5014404772 @default.
• W2148964182 creator A5016286778 @default.
• W2148964182 creator A5021903309 @default.
• W2148964182 creator A5026598177 @default.
• W2148964182 creator A5039794145 @default.
• W2148964182 creator A5042511675 @default.
• W2148964182 creator A5047559482 @default.
• W2148964182 creator A5050634480 @default.
• W2148964182 creator A5052865465 @default.
• W2148964182 creator A5059038204 @default.
• W2148964182 creator A5060634423 @default.
• W2148964182 creator A5061872948 @default.
• W2148964182 creator A5063541240 @default.
• W2148964182 creator A5064383725 @default.
• W2148964182 creator A5067228080 @default.
• W2148964182 creator A5068195667 @default.
• W2148964182 creator A5080417105 @default.
• W2148964182 creator A5080479952 @default.
• W2148964182 creator A5081842404 @default.
• W2148964182 creator A5085715708 @default.
• W2148964182 creator A5089552905 @default.
• W2148964182 date "2012-04-25" @default.
• W2148964182 modified "2023-10-10" @default.
• W2148964182 title "Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure" @default.
• W2148964182 cites W1511621596 @default.
• W2148964182 cites W180141685 @default.
• W2148964182 cites W1963820730 @default.
• W2148964182 cites W1972020976 @default.
• W2148964182 cites W1990372573 @default.
• W2148964182 cites W1994175579 @default.
• W2148964182 cites W2002995943 @default.
• W2148964182 cites W2006720016 @default.
• W2148964182 cites W2017682074 @default.
• W2148964182 cites W2032336215 @default.
• W2148964182 cites W2036084919 @default.
• W2148964182 cites W2042158174 @default.
• W2148964182 cites W2043945375 @default.
• W2148964182 cites W2075040668 @default.
• W2148964182 cites W2079670701 @default.
• W2148964182 cites W2082783124 @default.
• W2148964182 cites W2094802004 @default.
• W2148964182 cites W2101864642 @default.
• W2148964182 cites W2101876919 @default.
• W2148964182 cites W2103465143 @default.
• W2148964182 cites W2103821820 @default.
• W2148964182 cites W2104985497 @default.
• W2148964182 cites W2106036991 @default.
• W2148964182 cites W2106541240 @default.
• W2148964182 cites W2107328434 @default.
• W2148964182 cites W2110846909 @default.
• W2148964182 cites W2118082971 @default.
• W2148964182 cites W2118320202 @default.
• W2148964182 cites W2120240963 @default.
• W2148964182 cites W2122791877 @default.
• W2148964182 cites W2125435699 @default.
• W2148964182 cites W2126280736 @default.
• W2148964182 cites W2128306943 @default.
• W2148964182 cites W2128729174 @default.
• W2148964182 cites W2130452710 @default.
• W2148964182 cites W2132690415 @default.
• W2148964182 cites W2134072500 @default.
• W2148964182 cites W2135393619 @default.
• W2148964182 cites W2136818924 @default.
• W2148964182 cites W2137667379 @default.
• W2148964182 cites W2147778732 @default.
• W2148964182 cites W2147823464 @default.
• W2148964182 cites W2147916435 @default.
• W2148964182 cites W2148998706 @default.
• W2148964182 cites W2153356272 @default.
• W2148964182 cites W2155963578 @default.
• W2148964182 cites W2157043395 @default.
• W2148964182 cites W2157146503 @default.
• W2148964182 cites W2164171818 @default.
• W2148964182 cites W2165386509 @default.
• W2148964182 cites W2167694190 @default.
• W2148964182 cites W2228339316 @default.
• W2148964182 cites W4205691790 @default.
• W2148964182 cites W4206439534 @default.
• W2148964182 doi "https://doi.org/10.1093/jnci/djs191" @default.
• W2148964182 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3352832" @default.
• W2148964182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22534784" @default.
• W2148964182 hasPublicationYear "2012" @default.
• W2148964182 type Work @default.
• W2148964182 sameAs 2148964182 @default.
• W2148964182 citedByCount "196" @default.
• W2148964182 countsByYear W21489641822012 @default.
• W2148964182 countsByYear W21489641822013 @default.
• W2148964182 countsByYear W21489641822014 @default.
• W2148964182 countsByYear W21489641822015 @default.
• W2148964182 countsByYear W21489641822016 @default.
• W2148964182 countsByYear W21489641822017 @default.

• next