FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148968067> ?p ?o ?g. }

• W2148968067 endingPage "1131" @default.
• W2148968067 startingPage "1125" @default.
• W2148968067 abstract "The epidermal growth factor-seven transmembrane (EGF-TM7) family is a group of seven-span transmembrane receptors predominantly expressed by cells of the immune system. Family members CD97, EGF module-containing mucin-like receptor (EMR) 1, EMR2, EMR3, EMR4, and EGF-TM7-latrophilin-related protein are characterized by an extended extracellular region with a variable number of N-terminal EGF-like domains. EGF-TM7 receptors bind cellular ligands as demonstrated by the interaction of CD97 with decay accelerating factor (CD55) and dermatan sulfate. Investigating the effect of newly generated mAb on the migration of neutrophilic granulocytes, we here report for the first time in vivo data on the function of CD97. In dextran sulfate sodium-induced experimental colitis, we show that homing of adoptively transferred neutrophils to the colon was significantly delayed when cells were preincubated with CD97 mAb. The consequences of this defect in neutrophil migration for host defense are demonstrated in a murine model of Streptococcus pneumoniae-induced pneumonia. Mice treated with CD97 mAb to EGF domain 1 (1B2) and EGF domain 3 (1C5) displayed a reduced granulocytic inflammatory infiltrate at 20 h after inoculation. This was associated with a significantly enhanced outgrowth of bacteria in the lungs at 44 h and a strongly diminished survival. Together, these findings indicate an essential role for CD97 in the migration of neutrophils." @default.
• W2148968067 created "2016-06-24" @default.
• W2148968067 creator A5000113493 @default.
• W2148968067 creator A5005901882 @default.
• W2148968067 creator A5011548156 @default.
• W2148968067 creator A5036345568 @default.
• W2148968067 creator A5048965254 @default.
• W2148968067 creator A5060136306 @default.
• W2148968067 creator A5062253998 @default.
• W2148968067 creator A5085896083 @default.
• W2148968067 date "2004-01-15" @default.
• W2148968067 modified "2023-10-16" @default.
• W2148968067 title "The Epidermal Growth Factor-Seven Transmembrane (EGF-TM7) Receptor CD97 Is Required for Neutrophil Migration and Host Defense" @default.
• W2148968067 cites W1500833770 @default.
• W2148968067 cites W1562575950 @default.
• W2148968067 cites W1583577648 @default.
• W2148968067 cites W1965173162 @default.
• W2148968067 cites W1975051039 @default.
• W2148968067 cites W1980982223 @default.
• W2148968067 cites W1984842433 @default.
• W2148968067 cites W1985621966 @default.
• W2148968067 cites W1988719059 @default.
• W2148968067 cites W1995938657 @default.
• W2148968067 cites W2005659566 @default.
• W2148968067 cites W2010726206 @default.
• W2148968067 cites W2026879402 @default.
• W2148968067 cites W2028628443 @default.
• W2148968067 cites W2032150432 @default.
• W2148968067 cites W2032494769 @default.
• W2148968067 cites W2045268402 @default.
• W2148968067 cites W2052798492 @default.
• W2148968067 cites W2053901337 @default.
• W2148968067 cites W2053979707 @default.
• W2148968067 cites W2061814831 @default.
• W2148968067 cites W2066633592 @default.
• W2148968067 cites W2070488197 @default.
• W2148968067 cites W2071290544 @default.
• W2148968067 cites W2072229464 @default.
• W2148968067 cites W2074232365 @default.
• W2148968067 cites W2074585020 @default.
• W2148968067 cites W2090854294 @default.
• W2148968067 cites W2094056569 @default.
• W2148968067 cites W2097140043 @default.
• W2148968067 cites W2099675490 @default.
• W2148968067 cites W2099987453 @default.
• W2148968067 cites W2102864904 @default.
• W2148968067 cites W2111655511 @default.
• W2148968067 cites W2111980811 @default.
• W2148968067 cites W2112124618 @default.
• W2148968067 cites W2116194397 @default.
• W2148968067 cites W2140148673 @default.
• W2148968067 cites W2140858431 @default.
• W2148968067 cites W2141181488 @default.
• W2148968067 cites W2147204470 @default.
• W2148968067 cites W2157021835 @default.
• W2148968067 cites W2160005439 @default.
• W2148968067 cites W2163039494 @default.
• W2148968067 cites W2167903465 @default.
• W2148968067 cites W2169167040 @default.
• W2148968067 cites W2170997125 @default.
• W2148968067 cites W2172508938 @default.
• W2148968067 cites W2178334364 @default.
• W2148968067 cites W2299298909 @default.
• W2148968067 doi "https://doi.org/10.4049/jimmunol.172.2.1125" @default.
• W2148968067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14707087" @default.
• W2148968067 hasPublicationYear "2004" @default.
• W2148968067 type Work @default.
• W2148968067 sameAs 2148968067 @default.
• W2148968067 citedByCount "116" @default.
• W2148968067 countsByYear W21489680672012 @default.
• W2148968067 countsByYear W21489680672013 @default.
• W2148968067 countsByYear W21489680672014 @default.
• W2148968067 countsByYear W21489680672015 @default.
• W2148968067 countsByYear W21489680672016 @default.
• W2148968067 countsByYear W21489680672017 @default.
• W2148968067 countsByYear W21489680672018 @default.
• W2148968067 countsByYear W21489680672019 @default.
• W2148968067 countsByYear W21489680672020 @default.
• W2148968067 countsByYear W21489680672021 @default.
• W2148968067 countsByYear W21489680672022 @default.
• W2148968067 countsByYear W21489680672023 @default.
• W2148968067 crossrefType "journal-article" @default.
• W2148968067 hasAuthorship W2148968067A5000113493 @default.
• W2148968067 hasAuthorship W2148968067A5005901882 @default.
• W2148968067 hasAuthorship W2148968067A5011548156 @default.
• W2148968067 hasAuthorship W2148968067A5036345568 @default.
• W2148968067 hasAuthorship W2148968067A5048965254 @default.
• W2148968067 hasAuthorship W2148968067A5060136306 @default.
• W2148968067 hasAuthorship W2148968067A5062253998 @default.
• W2148968067 hasAuthorship W2148968067A5085896083 @default.
• W2148968067 hasBestOaLocation W21489680671 @default.
• W2148968067 hasConcept C111684460 @default.
• W2148968067 hasConcept C153911025 @default.
• W2148968067 hasConcept C170493617 @default.
• W2148968067 hasConcept C179264091 @default.
• W2148968067 hasConcept C203014093 @default.
• W2148968067 hasConcept C2776362946 @default.
• W2148968067 hasConcept C28406088 @default.

• next