FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148969684> ?p ?o ?g. }

• W2148969684 endingPage "1377" @default.
• W2148969684 startingPage "1363" @default.
• W2148969684 abstract "Rhabdomyolysis can be life threatening if complicated by AKI. Macrophage infiltration has been observed in rat kidneys after glycerol-induced rhabdomyolysis, but the role of macrophages in rhabdomyolysis-induced AKI remains unknown. Here, in a patient diagnosed with rhabdomyolysis, we detected substantial macrophage infiltration in the kidney. In a mouse model of rhabdomyolysis-induced AKI, diverse renal macrophage phenotypes were observed depending on the stage of the disease. Two days after rhabdomyolysis, F4/80(low)CD11b(high)Ly6b(high)CD206(low) kidney macrophages were dominant, whereas by day 8, F4/80(high)CD11b(+)Ly6b(low)CD206(high) cells became the most abundant. Single-cell gene expression analyses of FACS-sorted macrophages revealed that these subpopulations were heterogeneous and that individual cells simultaneously expressed both M1 and M2 markers. Liposomal clodronate-mediated macrophage depletion significantly reduced the early infiltration of F4/80(low)CD11b(high)Ly6b(high)CD206(low) macrophages. Furthermore, transcriptionally regulated targets potentially involved in disease progression, including fibronectin, collagen III, and chemoattractants that were identified via single-cell analysis, were verified as macrophage-dependent in situ. In vitro, myoglobin treatment induced proximal tubular cells to secrete chemoattractants and macrophages to express proinflammatory markers. At day 30, liposomal clodronate-mediated macrophage depletion reduced fibrosis and improved both kidney repair and mouse survival. Seven months after rhabdomyolysis, histologic lesions were still present but were substantially reduced with prior depletion of macrophages. These results suggest an important role for macrophages in rhabdomyolysis-induced AKI progression and advocate the utility of long-term follow-up for patients with this disease." @default.
• W2148969684 created "2016-06-24" @default.
• W2148969684 creator A5009141968 @default.
• W2148969684 creator A5016540292 @default.
• W2148969684 creator A5021185927 @default.
• W2148969684 creator A5025924823 @default.
• W2148969684 creator A5038102885 @default.
• W2148969684 creator A5050688019 @default.
• W2148969684 creator A5050823230 @default.
• W2148969684 creator A5067700551 @default.
• W2148969684 creator A5068459453 @default.
• W2148969684 creator A5069159045 @default.
• W2148969684 creator A5085429142 @default.
• W2148969684 creator A5090325119 @default.
• W2148969684 date "2014-09-30" @default.
• W2148969684 modified "2023-10-15" @default.
• W2148969684 title "Specific Macrophage Subtypes Influence the Progression of Rhabdomyolysis-Induced Kidney Injury" @default.
• W2148969684 cites W1967701621 @default.
• W2148969684 cites W1986528165 @default.
• W2148969684 cites W1999755139 @default.
• W2148969684 cites W2019442978 @default.
• W2148969684 cites W2021457916 @default.
• W2148969684 cites W2021690806 @default.
• W2148969684 cites W2031515819 @default.
• W2148969684 cites W2048451975 @default.
• W2148969684 cites W2052758686 @default.
• W2148969684 cites W2054897365 @default.
• W2148969684 cites W2065786649 @default.
• W2148969684 cites W2068050227 @default.
• W2148969684 cites W2079837262 @default.
• W2148969684 cites W2080766359 @default.
• W2148969684 cites W2081500137 @default.
• W2148969684 cites W2084162564 @default.
• W2148969684 cites W2086594925 @default.
• W2148969684 cites W2090116088 @default.
• W2148969684 cites W2093705034 @default.
• W2148969684 cites W2094742966 @default.
• W2148969684 cites W2101617710 @default.
• W2148969684 cites W2101994094 @default.
• W2148969684 cites W2102556842 @default.
• W2148969684 cites W2104760558 @default.
• W2148969684 cites W2107655383 @default.
• W2148969684 cites W2110720586 @default.
• W2148969684 cites W2114412986 @default.
• W2148969684 cites W2136049487 @default.
• W2148969684 cites W2136691602 @default.
• W2148969684 cites W2142503533 @default.
• W2148969684 cites W2146152479 @default.
• W2148969684 cites W2155490506 @default.
• W2148969684 cites W2158944380 @default.
• W2148969684 cites W2165240849 @default.
• W2148969684 cites W2167055272 @default.
• W2148969684 cites W2167830630 @default.
• W2148969684 cites W2168784022 @default.
• W2148969684 cites W2187284446 @default.
• W2148969684 cites W4237767968 @default.
• W2148969684 cites W4249643093 @default.
• W2148969684 doi "https://doi.org/10.1681/asn.2014040320" @default.
• W2148969684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4446873" @default.
• W2148969684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25270069" @default.
• W2148969684 hasPublicationYear "2014" @default.
• W2148969684 type Work @default.
• W2148969684 sameAs 2148969684 @default.
• W2148969684 citedByCount "112" @default.
• W2148969684 countsByYear W21489696842015 @default.
• W2148969684 countsByYear W21489696842016 @default.
• W2148969684 countsByYear W21489696842017 @default.
• W2148969684 countsByYear W21489696842018 @default.
• W2148969684 countsByYear W21489696842019 @default.
• W2148969684 countsByYear W21489696842020 @default.
• W2148969684 countsByYear W21489696842021 @default.
• W2148969684 countsByYear W21489696842022 @default.
• W2148969684 countsByYear W21489696842023 @default.
• W2148969684 crossrefType "journal-article" @default.
• W2148969684 hasAuthorship W2148969684A5009141968 @default.
• W2148969684 hasAuthorship W2148969684A5016540292 @default.
• W2148969684 hasAuthorship W2148969684A5021185927 @default.
• W2148969684 hasAuthorship W2148969684A5025924823 @default.
• W2148969684 hasAuthorship W2148969684A5038102885 @default.
• W2148969684 hasAuthorship W2148969684A5050688019 @default.
• W2148969684 hasAuthorship W2148969684A5050823230 @default.
• W2148969684 hasAuthorship W2148969684A5067700551 @default.
• W2148969684 hasAuthorship W2148969684A5068459453 @default.
• W2148969684 hasAuthorship W2148969684A5069159045 @default.
• W2148969684 hasAuthorship W2148969684A5085429142 @default.
• W2148969684 hasAuthorship W2148969684A5090325119 @default.
• W2148969684 hasBestOaLocation W21489696841 @default.
• W2148969684 hasConcept C126322002 @default.
• W2148969684 hasConcept C142724271 @default.
• W2148969684 hasConcept C153400128 @default.
• W2148969684 hasConcept C159985019 @default.
• W2148969684 hasConcept C164027704 @default.
• W2148969684 hasConcept C171779818 @default.
• W2148969684 hasConcept C192562407 @default.
• W2148969684 hasConcept C202751555 @default.
• W2148969684 hasConcept C203014093 @default.
• W2148969684 hasConcept C2776914184 @default.
• W2148969684 hasConcept C2778653478 @default.

• next