FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148974827> ?p ?o ?g. }

• W2148974827 endingPage "868" @default.
• W2148974827 startingPage "861" @default.
• W2148974827 abstract "Preeclampsia is a devastating pregnancy-associated disorder affecting 5% to 8% of pregnant women worldwide. It emerges as an autoimmune-driven disease, and, among others, the autoantibodies against angiotensin type 1 receptor II have been proposed to account for preeclampsia symptoms. Despite much attention focused on describing autoantibodies associated with preeclampsia, there is no clue concerning the cell population producing them. CD19 + CD5 + B-1a B cells constitute the main source of natural and polyreactive antibodies, which can be directed against own structures. Here, we aimed to identify the B-cell subpopulation responsible for autoantibody production during preeclampsia and to study their regulation, as well as their possible use as markers for the disease. The frequency of CD19 + CD5 + cells in peripheral blood of preeclamptic patients is dramatically increased compared with normal pregnant women as analyzed by flow cytometry. This seems to be driven by the high human chorionic gonadotropin levels present in the serum and placenta supernatant of preeclamptic patients versus normal pregnant women. Not only ≈95% of CD19 + CD5 + cells express the human chorionic gonadotropin receptor, but these cells also expand on human chorionic gonadotropin stimulation in a lymphocyte culture. Most importantly, isolated CD19 + CD5 + cells produce autoantibodies against angiotensin type 1 receptor II, and CD19 + CD5 + cells were further detected in the placenta of preeclamptic but not of normal pregnancies where barely B cells are present. Our results identify a B-cell population able to produce pregnancy-pathological autoantibodies as possible markers for preeclampsia, which opens vast diagnostic and therapeutic applications." @default.
• W2148974827 created "2016-06-24" @default.
• W2148974827 creator A5044649936 @default.
• W2148974827 creator A5057696929 @default.
• W2148974827 creator A5067934673 @default.
• W2148974827 creator A5072584326 @default.
• W2148974827 creator A5073180606 @default.
• W2148974827 creator A5078018907 @default.
• W2148974827 creator A5084769052 @default.
• W2148974827 creator A5085366797 @default.
• W2148974827 date "2012-04-01" @default.
• W2148974827 modified "2023-10-17" @default.
• W2148974827 title "CD19 ⁺ CD5 ⁺ Cells as Indicators of Preeclampsia" @default.
• W2148974827 cites W1489759107 @default.
• W2148974827 cites W1502694991 @default.
• W2148974827 cites W1571029847 @default.
• W2148974827 cites W1946521533 @default.
• W2148974827 cites W1964521734 @default.
• W2148974827 cites W1965418852 @default.
• W2148974827 cites W1970423635 @default.
• W2148974827 cites W1981003679 @default.
• W2148974827 cites W1986910957 @default.
• W2148974827 cites W1988422289 @default.
• W2148974827 cites W2012751406 @default.
• W2148974827 cites W2024049821 @default.
• W2148974827 cites W2027133133 @default.
• W2148974827 cites W2029890313 @default.
• W2148974827 cites W2033899346 @default.
• W2148974827 cites W2049653208 @default.
• W2148974827 cites W2051203706 @default.
• W2148974827 cites W2051759187 @default.
• W2148974827 cites W2055416932 @default.
• W2148974827 cites W2069284859 @default.
• W2148974827 cites W2074747030 @default.
• W2148974827 cites W2075337276 @default.
• W2148974827 cites W2076468757 @default.
• W2148974827 cites W2084825289 @default.
• W2148974827 cites W2089221056 @default.
• W2148974827 cites W2090913356 @default.
• W2148974827 cites W2100640968 @default.
• W2148974827 cites W2102134390 @default.
• W2148974827 cites W2103221499 @default.
• W2148974827 cites W2106545917 @default.
• W2148974827 cites W2112962699 @default.
• W2148974827 cites W2135029910 @default.
• W2148974827 cites W2140785684 @default.
• W2148974827 cites W2145729033 @default.
• W2148974827 cites W2147108540 @default.
• W2148974827 cites W2153213544 @default.
• W2148974827 cites W2160705469 @default.
• W2148974827 cites W2162381208 @default.
• W2148974827 cites W2164878633 @default.
• W2148974827 cites W2170458458 @default.
• W2148974827 cites W2130106713 @default.
• W2148974827 doi "https://doi.org/10.1161/hypertensionaha.111.188276" @default.
• W2148974827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22353610" @default.
• W2148974827 hasPublicationYear "2012" @default.
• W2148974827 type Work @default.
• W2148974827 sameAs 2148974827 @default.
• W2148974827 citedByCount "104" @default.
• W2148974827 countsByYear W21489748272012 @default.
• W2148974827 countsByYear W21489748272013 @default.
• W2148974827 countsByYear W21489748272014 @default.
• W2148974827 countsByYear W21489748272015 @default.
• W2148974827 countsByYear W21489748272016 @default.
• W2148974827 countsByYear W21489748272017 @default.
• W2148974827 countsByYear W21489748272018 @default.
• W2148974827 countsByYear W21489748272019 @default.
• W2148974827 countsByYear W21489748272020 @default.
• W2148974827 countsByYear W21489748272021 @default.
• W2148974827 countsByYear W21489748272022 @default.
• W2148974827 countsByYear W21489748272023 @default.
• W2148974827 crossrefType "journal-article" @default.
• W2148974827 hasAuthorship W2148974827A5044649936 @default.
• W2148974827 hasAuthorship W2148974827A5057696929 @default.
• W2148974827 hasAuthorship W2148974827A5067934673 @default.
• W2148974827 hasAuthorship W2148974827A5072584326 @default.
• W2148974827 hasAuthorship W2148974827A5073180606 @default.
• W2148974827 hasAuthorship W2148974827A5078018907 @default.
• W2148974827 hasAuthorship W2148974827A5084769052 @default.
• W2148974827 hasAuthorship W2148974827A5085366797 @default.
• W2148974827 hasBestOaLocation W21489748271 @default.
• W2148974827 hasConcept C113067387 @default.
• W2148974827 hasConcept C126322002 @default.
• W2148974827 hasConcept C134018914 @default.
• W2148974827 hasConcept C159654299 @default.
• W2148974827 hasConcept C163764329 @default.
• W2148974827 hasConcept C203014093 @default.
• W2148974827 hasConcept C2775948956 @default.
• W2148974827 hasConcept C2777218350 @default.
• W2148974827 hasConcept C2778957590 @default.
• W2148974827 hasConcept C2779234561 @default.
• W2148974827 hasConcept C2908647359 @default.
• W2148974827 hasConcept C54355233 @default.
• W2148974827 hasConcept C71315377 @default.
• W2148974827 hasConcept C71924100 @default.
• W2148974827 hasConcept C86803240 @default.
• W2148974827 hasConcept C99454951 @default.

• next