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• W2149012358 abstract "The mechanoelectrical transducer (MET) is a crucial component of mammalian auditory system. The gating mechanism of the MET channel remains a puzzling issue, though there are many speculations, due to the lack of essential molecular building blocks. To understand the working principle of mammalian MET, we propose a molecular level prototype which constitutes a charged blocker, a realistic ion channel and its surrounding membrane. To validate the proposed prototype, we make use of a well-established ion channel theory, the Poisson-Nernst-Planck equations, for three-dimensional (3D) numerical simulations. A wide variety of model parameters, including bulk ion concentration, applied external voltage, blocker charge and blocker displacement, are explored to understand the basic function of the proposed MET prototype. We show that our prototype prediction of channel open probability in response to blocker relative displacement is in remarkable accordance with experimental observation of rat cochlea outer hair cells. Our results appear to suggest that tip links which connect hair bundles gate MET channels." @default.
• W2149012358 created "2016-06-24" @default.
• W2149012358 creator A5003301140 @default.
• W2149012358 creator A5038778212 @default.
• W2149012358 date "2013-04-28" @default.
• W2149012358 modified "2023-09-23" @default.
• W2149012358 title "A molecular level prototype for mechanoelectrical transducer in mammalian hair cells" @default.
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• W2149012358 doi "https://doi.org/10.1007/s10827-013-0450-z" @default.
• W2149012358 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3732576" @default.
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