Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149014007> ?p ?o ?g. }
- W2149014007 endingPage "1136" @default.
- W2149014007 startingPage "1124" @default.
- W2149014007 abstract "The activation of Toll-like receptors (TLRs) in dendritic cells (DCs) triggers a rapid inflammatory response to pathogens. However, this response must be tightly regulated because unrestrained TLR signaling generates a chronic inflammatory milieu that often leads to autoimmunity. We have found that the TAM receptor tyrosine kinases-Tyro3, Axl, and Mer-broadly inhibit both TLR and TLR-induced cytokine-receptor cascades. Remarkably, TAM inhibition of inflammation is transduced through an essential stimulator of inflammation-the type I interferon receptor (IFNAR)-and its associated transcription factor STAT1. TLR induction of IFNAR-STAT1 signaling upregulates the TAM system, which in turn usurps the IFNAR-STAT1 cassette to induce the cytokine and TLR suppressors SOCS1 and SOCS3. These results illuminate a self-regulating cycle of inflammation, in which the obligatory, cytokine-dependent activation of TAM signaling hijacks a proinflammatory pathway to provide an intrinsic feedback inhibitor of both TLR- and cytokine-driven immune responses." @default.
- W2149014007 created "2016-06-24" @default.
- W2149014007 creator A5001380638 @default.
- W2149014007 creator A5023260904 @default.
- W2149014007 creator A5065903201 @default.
- W2149014007 creator A5073298216 @default.
- W2149014007 creator A5082732480 @default.
- W2149014007 date "2007-12-01" @default.
- W2149014007 modified "2023-10-10" @default.
- W2149014007 title "TAM Receptors Are Pleiotropic Inhibitors of the Innate Immune Response" @default.
- W2149014007 cites W1520625797 @default.
- W2149014007 cites W1646925026 @default.
- W2149014007 cites W1694093395 @default.
- W2149014007 cites W1821858011 @default.
- W2149014007 cites W1959486232 @default.
- W2149014007 cites W1971602395 @default.
- W2149014007 cites W1983762311 @default.
- W2149014007 cites W1985477675 @default.
- W2149014007 cites W1995744610 @default.
- W2149014007 cites W1996842103 @default.
- W2149014007 cites W2004829503 @default.
- W2149014007 cites W2005884645 @default.
- W2149014007 cites W2010453472 @default.
- W2149014007 cites W2011617127 @default.
- W2149014007 cites W2015087086 @default.
- W2149014007 cites W2019676172 @default.
- W2149014007 cites W2022767724 @default.
- W2149014007 cites W2034763496 @default.
- W2149014007 cites W2035319097 @default.
- W2149014007 cites W2056010443 @default.
- W2149014007 cites W2056502408 @default.
- W2149014007 cites W2078119649 @default.
- W2149014007 cites W2085878503 @default.
- W2149014007 cites W2088904620 @default.
- W2149014007 cites W2090640877 @default.
- W2149014007 cites W2092921155 @default.
- W2149014007 cites W2108764429 @default.
- W2149014007 cites W2111922856 @default.
- W2149014007 cites W2114335223 @default.
- W2149014007 cites W2116776475 @default.
- W2149014007 cites W2122767209 @default.
- W2149014007 cites W2133779525 @default.
- W2149014007 cites W2134505828 @default.
- W2149014007 cites W2135492013 @default.
- W2149014007 cites W2137108685 @default.
- W2149014007 cites W2139380919 @default.
- W2149014007 cites W2145221987 @default.
- W2149014007 cites W2150250882 @default.
- W2149014007 cites W2158969445 @default.
- W2149014007 cites W4289257252 @default.
- W2149014007 cites W4313344687 @default.
- W2149014007 doi "https://doi.org/10.1016/j.cell.2007.10.034" @default.
- W2149014007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18083102" @default.
- W2149014007 hasPublicationYear "2007" @default.
- W2149014007 type Work @default.
- W2149014007 sameAs 2149014007 @default.
- W2149014007 citedByCount "838" @default.
- W2149014007 countsByYear W21490140072012 @default.
- W2149014007 countsByYear W21490140072013 @default.
- W2149014007 countsByYear W21490140072014 @default.
- W2149014007 countsByYear W21490140072015 @default.
- W2149014007 countsByYear W21490140072016 @default.
- W2149014007 countsByYear W21490140072017 @default.
- W2149014007 countsByYear W21490140072018 @default.
- W2149014007 countsByYear W21490140072019 @default.
- W2149014007 countsByYear W21490140072020 @default.
- W2149014007 countsByYear W21490140072021 @default.
- W2149014007 countsByYear W21490140072022 @default.
- W2149014007 countsByYear W21490140072023 @default.
- W2149014007 crossrefType "journal-article" @default.
- W2149014007 hasAuthorship W2149014007A5001380638 @default.
- W2149014007 hasAuthorship W2149014007A5023260904 @default.
- W2149014007 hasAuthorship W2149014007A5065903201 @default.
- W2149014007 hasAuthorship W2149014007A5073298216 @default.
- W2149014007 hasAuthorship W2149014007A5082732480 @default.
- W2149014007 hasBestOaLocation W21490140071 @default.
- W2149014007 hasConcept C112392421 @default.
- W2149014007 hasConcept C121608353 @default.
- W2149014007 hasConcept C126042315 @default.
- W2149014007 hasConcept C136449434 @default.
- W2149014007 hasConcept C14077384 @default.
- W2149014007 hasConcept C154390347 @default.
- W2149014007 hasConcept C162354598 @default.
- W2149014007 hasConcept C164027704 @default.
- W2149014007 hasConcept C170493617 @default.
- W2149014007 hasConcept C179185449 @default.
- W2149014007 hasConcept C203014093 @default.
- W2149014007 hasConcept C2776914184 @default.
- W2149014007 hasConcept C2777003663 @default.
- W2149014007 hasConcept C2778690821 @default.
- W2149014007 hasConcept C2778923194 @default.
- W2149014007 hasConcept C54355233 @default.
- W2149014007 hasConcept C55493867 @default.
- W2149014007 hasConcept C62478195 @default.
- W2149014007 hasConcept C86803240 @default.
- W2149014007 hasConcept C8891405 @default.
- W2149014007 hasConcept C95444343 @default.
- W2149014007 hasConceptScore W2149014007C112392421 @default.