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- W2149015845 abstract "ABSTRACT The rat parvovirus H-1 (H-1PV) attracts high attention as an anticancer agent, because it is not pathogenic for humans and has oncotropic and oncosuppressive properties. The viral nonstructural NS1 protein is thought to mediate H-1PV cytotoxicity, but its exact contribution to this process remains undefined. In this study, we analyzed the effects of the H-1PV NS1 protein on human cell proliferation and cell viability. We show that NS1 expression is sufficient to induce the accumulation of cells in G 2 phase, apoptosis via caspase 9 and 3 activation, and cell lysis. Similarly, cells infected with wild-type H-1PV arrest in G 2 phase and undergo apoptosis. Furthermore, we also show that both expression of NS1 and H-1PV infection lead to higher levels of intracellular reactive oxygen species (ROS), associated with DNA double-strand breaks. Antioxidant treatment reduces ROS levels and strongly decreases NS1- and virus-induced DNA damage, cell cycle arrest, and apoptosis, indicating that NS1-induced ROS are important mediators of H-1PV cytotoxicity." @default.
- W2149015845 created "2016-06-24" @default.
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- W2149015845 date "2010-06-15" @default.
- W2149015845 modified "2023-10-16" @default.
- W2149015845 title "Through Its Nonstructural Protein NS1, Parvovirus H-1 Induces Apoptosis via Accumulation of Reactive Oxygen Species" @default.
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- W2149015845 doi "https://doi.org/10.1128/jvi.01797-09" @default.
- W2149015845 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2876649" @default.
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- W2149015845 hasPublicationYear "2010" @default.
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