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• W2149018580 abstract "We have investigated the molecular epidemiology and distribution of carbapenemase genes in 492 imipenem-non-susceptible Acinetobacter baumannii worldwide isolates (North and Latin America, Europe, Asia, South Africa and Australia). MICs were determined by broth microdilution and Etest. The presence of carbapenemase-encoding genes was investigated by PCR. Molecular epidemiology was performed by repetitive sequence-based PCR (rep-PCR; DiversiLab), sequence-type multiplex PCR and PFGE. Imipenem non-susceptibility was associated with ISAba1 upstream of the intrinsic blaOXA-51-like or the acquired carbapenemase blaOXA-23-like, blaOXA-40-like or blaOXA-58-like. Isolates were grouped into eight distinct clusters including European clones I, II and III. European clone II was the largest (246 isolates) and most widespread group (USA, pan-Europe, Israel, Asia, Australia and South Africa). The global dissemination of eight carbapenem-resistant lineages illustrates the success this organism has had in epidemic spread. The acquired OXA enzymes are widely distributed but are not the sole carbapenem resistance determinant in A. baumannii." @default.
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• W2149018580 date "2009-12-08" @default.
• W2149018580 modified "2023-09-30" @default.
• W2149018580 title "Global spread of carbapenem-resistant Acinetobacter baumannii" @default.
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• W2149018580 doi "https://doi.org/10.1093/jac/dkp428" @default.
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