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- W2149018868 abstract "The technique of recording spinal cord withdrawal reflexes as single motor units (SMUs) does not require intense preparatory surgery and allows the study of the nociceptive system in physiological conditions. It has been used to show that the wind-up phenomenon depends on the level of excitability of spinal cord neurones, the integrity of the spinal cord and the parameters of the stimulation used. We have now used SMU recordings to assess whether wind-up is also an heterogeneous phenomenon depending on the muscle studied, and, if so, how the presence of hyperalgesia affects its generation. The experiments were performed in normal and carrageenan-induced inflammation in male Wistar rats anesthetized with alpha-chloralose. Wind-up was recorded in units from peroneus longus, tibialis anterior and extensor digitorum longus. The results showed that in normal animals, the curves of C-fibre mediated wind-up reached saturation at different times and the shape of the curves was different depending on the muscle studied and on the intensity of stimulation used. In inflammation, however, C-fibre mediated wind-up became very uniform in the muscles studied, with a similar shape and saturation point. A-fibre mediated wind-up was only observed in animals with inflammation and no differences were observed between muscles. We conclude that in the absence of preparatory surgery and inflammation, C-fibre wind-up is heterogeneous, and supports a modular organization of nociceptive spinal reflexes. In hyperalgesia, however, wind-up curves are similar in units from different muscles, confirming a loss of modular organization that also affects the generation of wind-up." @default.
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- W2149018868 date "2003-07-01" @default.
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- W2149018868 title "Male Wistar rats show uniform wind-up responses in carrageenan-induced inflammation but not in the normal situation" @default.
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- W2149018868 doi "https://doi.org/10.1258/002367703766453056" @default.
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