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• W2149022414 abstract "The thyroid-stimulating hormone/thyrotropin (TSH) is the most relevant hormone in the control of thyroid gland physiology in adulthood. TSH effects on the thyroid gland are mediated by the interaction with a specific TSH receptor (TSHR). We studied the role of TSH/TSHR signaling on gland morphogenesis and differentiation in the mouse embryo using mouse lines deprived either of TSH ( pit dw / pit dw ) or of a functional TSHR ( tshr hyt / tshr hyt and TSHR -knockout lines). The results reported here show that in the absence of either TSH or a functional TSHR, the thyroid gland develops to a normal size, whereas the expression of thyroperoxidase and the sodium/iodide symporter are reduced greatly. Conversely, no relevant changes are detected in the amounts of thyroglobulin and the thyroid-enriched transcription factors TTF-1, TTF-2, and Pax8. These data suggest that the major role of the TSH/TSHR pathway is in controlling genes involved in iodide metabolism such as sodium/iodide symporter and thyroperoxidase. Furthermore, our data indicate that in embryonic life TSH does not play an equivalent role in controlling gland growth as in the adult thyroid." @default.
• W2149022414 created "2016-06-24" @default.
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• W2149022414 date "2002-11-13" @default.
• W2149022414 modified "2023-10-17" @default.
• W2149022414 title "Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland" @default.
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• W2149022414 doi "https://doi.org/10.1073/pnas.242328999" @default.
• W2149022414 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/137739" @default.
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