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• W2149027421 startingPage "1163" @default.
• W2149027421 abstract "ABSTRACT Yersinia pestis , the causative agent of plague, autoaggregates within a few minutes of cessation of shaking when grown at 28°C. To identify the autoaggregation factor of Y. pestis , we performed mariner -based transposon mutagenesis. Autoaggregation-defective mutants from three different pools were identified, each with a transposon insertion at a different position within the gene encoding phosphoglucomutase ( pgmA ; y1258 ). Targeted deletion of pgmA in Y. pestis KIM5 also resulted in loss of autoaggregation. Given the previously defined role for phosphoglucomutase in antimicrobial peptide resistance in other organisms, we tested the KIM5 Δ pgmA mutant for antimicrobial peptide sensitivity. The Δ pgmA mutant displayed >1,000-fold increased sensitivity to polymyxin B compared to the parental Y. pestis strain, KIM5. This sensitivity is not due to changes in lipopolysaccharide (LPS) since the LPSs from both Y. pestis KIM5 and the Δ pgmA mutant are identical based on a comparison of their structures by mass spectrometry (MS), tandem MS, and nuclear magnetic resonance analyses. Furthermore, the ability of polymyxin B to neutralize LPS toxicity was identical for LPS purified from both KIM5 and the Δ pgmA mutant. Our results indicate that increased polymyxin B sensitivity of the Δ pgmA mutant is due to changes in surface structures other than LPS. Experiments with mice via the intravenous and intranasal routes did not demonstrate any virulence defect for the Δ pgmA mutant, nor was flea colonization or blockage affected. Our findings suggest that the activity of PgmA results in modification and/or elaboration of a surface component of Y. pestis responsible for autoaggregation and polymyxin B resistance." @default.
• W2149027421 created "2016-06-24" @default.
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• W2149027421 date "2010-03-01" @default.
• W2149027421 modified "2023-10-15" @default.
• W2149027421 title "Phosphoglucomutase of <i>Yersinia pestis</i> Is Required for Autoaggregation and Polymyxin B Resistance" @default.
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• W2149027421 doi "https://doi.org/10.1128/iai.00997-09" @default.
• W2149027421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2825912" @default.
• W2149027421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20028810" @default.
• W2149027421 hasPublicationYear "2010" @default.
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