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- W2149041672 abstract "The macrolide lactone, tacrolimus (FK506), is utilized in bone marrow transplantation (BMT) to prevent graft-versus-host disease (GVHD). In the current study, we evaluated the ability of FK506 to modify the function of dendritic cells (DCs) derived from CD34+ hematopoietic progenitor cells (HPCs). Comparable to DCs obtained in the absence of FK506, DCs cultured in the presence of FK506 (FK-DCs) had higher expression of CD1a+ and formed a greater number of DC colonies. Despite the same expression of costimulatory molecules, FK-DCs displayed a reduced capacity to stimulate an allogeneic T cell response, and showed significantly lower interleukin (IL)-12 production. While normal DCs pulsed with the exogenous antigen, keyhole limpet hemocyanin (KLH) induced specific Th1-like interferon-gamma(IFN-gamma) producing CD4+ T cell line, FK-DCs induced Th2-like interleukin-4 (IL-4) producing CD4+ T cell line. These data demonstrate the ability of FK506 to induce Th2-promoting function in developing DCs." @default.
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- W2149041672 date "2000-11-01" @default.
- W2149041672 modified "2023-10-10" @default.
- W2149041672 title "Tacrolimus (FK506) treatment of CD34 <sup>+</sup> hematopoietic progenitor cells promote the development of dendritic cells that drive CD4 <sup>+</sup> T cells toward Th2 responses" @default.
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- W2149041672 doi "https://doi.org/10.1189/jlb.68.5.633" @default.
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