Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149043407> ?p ?o ?g. }
- W2149043407 endingPage "8" @default.
- W2149043407 startingPage "1" @default.
- W2149043407 abstract "Study objective To determine whether supplemental oxygen reduces the incidence of hypoxia by 20% in study patients receiving midazolam and fentanyl for emergency department procedural sedation and analgesia. Methods Patients were randomized to receive either supplemental oxygen or compressed air by nasal cannula at 2 L per minute. Physicians were blinded to the gas used and end-tidal carbon dioxide (etco2) data. Respiratory depression was defined a priori as oxygen saturation less than 90%, etco2 level greater than 50 mm Hg, an absolute change from baseline of 10 mm Hg, or loss of the etco2 waveform. Results Of the 80 patients analyzed, 44 received supplemental oxygen and 36 received compressed air. Twenty supplemental oxygen patients and 19 compressed air patients met at least 1 criterion for respiratory depression. Six supplemental oxygen patients and 5 compressed air patients experienced hypoxia (P=.97; effect size 0%; 95% confidence interval –15% to +15%). Fourteen patients in each group met etco2 criteria for respiratory depression but were not hypoxic. Physicians identified respiratory depression in 8 of 11 patients who became hypoxic and 0 of 28 patients who met etco2 criteria for respiratory depression but who did not become hypoxic. There were no adverse events. Conclusion Supplemental oxygen did not reduce (or trend toward reducing) the incidence of hypoxia in patients moderately sedated with midazolam and fentanyl. However, our lower-than-expected rate of hypoxia limits the power of this comparison. Blinded capnography frequently identified respiratory depression undetected by the treating physicians. To determine whether supplemental oxygen reduces the incidence of hypoxia by 20% in study patients receiving midazolam and fentanyl for emergency department procedural sedation and analgesia. Patients were randomized to receive either supplemental oxygen or compressed air by nasal cannula at 2 L per minute. Physicians were blinded to the gas used and end-tidal carbon dioxide (etco2) data. Respiratory depression was defined a priori as oxygen saturation less than 90%, etco2 level greater than 50 mm Hg, an absolute change from baseline of 10 mm Hg, or loss of the etco2 waveform. Of the 80 patients analyzed, 44 received supplemental oxygen and 36 received compressed air. Twenty supplemental oxygen patients and 19 compressed air patients met at least 1 criterion for respiratory depression. Six supplemental oxygen patients and 5 compressed air patients experienced hypoxia (P=.97; effect size 0%; 95% confidence interval –15% to +15%). Fourteen patients in each group met etco2 criteria for respiratory depression but were not hypoxic. Physicians identified respiratory depression in 8 of 11 patients who became hypoxic and 0 of 28 patients who met etco2 criteria for respiratory depression but who did not become hypoxic. There were no adverse events. Supplemental oxygen did not reduce (or trend toward reducing) the incidence of hypoxia in patients moderately sedated with midazolam and fentanyl. However, our lower-than-expected rate of hypoxia limits the power of this comparison. Blinded capnography frequently identified respiratory depression undetected by the treating physicians." @default.
- W2149043407 created "2016-06-24" @default.
- W2149043407 creator A5007916952 @default.
- W2149043407 creator A5054367343 @default.
- W2149043407 creator A5077235151 @default.
- W2149043407 date "2007-01-01" @default.
- W2149043407 modified "2023-09-26" @default.
- W2149043407 title "The Utility of Supplemental Oxygen During Emergency Department Procedural Sedation and Analgesia With Midazolam and Fentanyl: A Randomized, Controlled Trial" @default.
- W2149043407 cites W2011663156 @default.
- W2149043407 cites W2014406350 @default.
- W2149043407 cites W2015469088 @default.
- W2149043407 cites W2019227969 @default.
- W2149043407 cites W2019418230 @default.
- W2149043407 cites W2025558285 @default.
- W2149043407 cites W2026393645 @default.
- W2149043407 cites W2043669389 @default.
- W2149043407 cites W2064218805 @default.
- W2149043407 cites W2074396726 @default.
- W2149043407 cites W2076834292 @default.
- W2149043407 cites W2083343637 @default.
- W2149043407 cites W2090116271 @default.
- W2149043407 cites W2128643063 @default.
- W2149043407 cites W2134102731 @default.
- W2149043407 cites W2318822860 @default.
- W2149043407 cites W4247487567 @default.
- W2149043407 cites W4253096148 @default.
- W2149043407 doi "https://doi.org/10.1016/j.annemergmed.2006.06.013" @default.
- W2149043407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16978741" @default.
- W2149043407 hasPublicationYear "2007" @default.
- W2149043407 type Work @default.
- W2149043407 sameAs 2149043407 @default.
- W2149043407 citedByCount "83" @default.
- W2149043407 countsByYear W21490434072012 @default.
- W2149043407 countsByYear W21490434072013 @default.
- W2149043407 countsByYear W21490434072014 @default.
- W2149043407 countsByYear W21490434072015 @default.
- W2149043407 countsByYear W21490434072016 @default.
- W2149043407 countsByYear W21490434072017 @default.
- W2149043407 countsByYear W21490434072018 @default.
- W2149043407 countsByYear W21490434072019 @default.
- W2149043407 countsByYear W21490434072020 @default.
- W2149043407 countsByYear W21490434072021 @default.
- W2149043407 countsByYear W21490434072023 @default.
- W2149043407 crossrefType "journal-article" @default.
- W2149043407 hasAuthorship W2149043407A5007916952 @default.
- W2149043407 hasAuthorship W2149043407A5054367343 @default.
- W2149043407 hasAuthorship W2149043407A5077235151 @default.
- W2149043407 hasConcept C118552586 @default.
- W2149043407 hasConcept C141071460 @default.
- W2149043407 hasConcept C168563851 @default.
- W2149043407 hasConcept C178790620 @default.
- W2149043407 hasConcept C185592680 @default.
- W2149043407 hasConcept C2776779939 @default.
- W2149043407 hasConcept C2776814716 @default.
- W2149043407 hasConcept C2778000748 @default.
- W2149043407 hasConcept C2778074680 @default.
- W2149043407 hasConcept C2778207410 @default.
- W2149043407 hasConcept C2780334268 @default.
- W2149043407 hasConcept C2780724011 @default.
- W2149043407 hasConcept C2781072394 @default.
- W2149043407 hasConcept C2781326671 @default.
- W2149043407 hasConcept C42219234 @default.
- W2149043407 hasConcept C540031477 @default.
- W2149043407 hasConcept C71924100 @default.
- W2149043407 hasConcept C7836513 @default.
- W2149043407 hasConceptScore W2149043407C118552586 @default.
- W2149043407 hasConceptScore W2149043407C141071460 @default.
- W2149043407 hasConceptScore W2149043407C168563851 @default.
- W2149043407 hasConceptScore W2149043407C178790620 @default.
- W2149043407 hasConceptScore W2149043407C185592680 @default.
- W2149043407 hasConceptScore W2149043407C2776779939 @default.
- W2149043407 hasConceptScore W2149043407C2776814716 @default.
- W2149043407 hasConceptScore W2149043407C2778000748 @default.
- W2149043407 hasConceptScore W2149043407C2778074680 @default.
- W2149043407 hasConceptScore W2149043407C2778207410 @default.
- W2149043407 hasConceptScore W2149043407C2780334268 @default.
- W2149043407 hasConceptScore W2149043407C2780724011 @default.
- W2149043407 hasConceptScore W2149043407C2781072394 @default.
- W2149043407 hasConceptScore W2149043407C2781326671 @default.
- W2149043407 hasConceptScore W2149043407C42219234 @default.
- W2149043407 hasConceptScore W2149043407C540031477 @default.
- W2149043407 hasConceptScore W2149043407C71924100 @default.
- W2149043407 hasConceptScore W2149043407C7836513 @default.
- W2149043407 hasIssue "1" @default.
- W2149043407 hasLocation W21490434071 @default.
- W2149043407 hasLocation W21490434072 @default.
- W2149043407 hasOpenAccess W2149043407 @default.
- W2149043407 hasPrimaryLocation W21490434071 @default.
- W2149043407 hasRelatedWork W1978560216 @default.
- W2149043407 hasRelatedWork W2025499314 @default.
- W2149043407 hasRelatedWork W2049292659 @default.
- W2149043407 hasRelatedWork W2090840481 @default.
- W2149043407 hasRelatedWork W2361468386 @default.
- W2149043407 hasRelatedWork W2377867091 @default.
- W2149043407 hasRelatedWork W2387180402 @default.
- W2149043407 hasRelatedWork W2389004264 @default.
- W2149043407 hasRelatedWork W2887406189 @default.
- W2149043407 hasRelatedWork W3032195257 @default.