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- W2149043451 abstract "Although the greatest burden of cardiovascular disease occurs after age 65 years, limited efficacy and safety data are available for cholesterol-lowering drugs in elderly patients. We undertook a pooled analysis of individual data from 13,282 patients aged 18–93 years in 16 published trials of ezetimibe and ezetimibe added on to or coadministered with a statin (ezetimibe/statin). Overall, ezetimibe reduced low-density lipoprotein cholesterol by 20% compared with placebo and ezetimibe/statin reduced low-density lipoprotein cholesterol by 17% compared with a statin alone, with consistent treatment effects across age groups (<65, 65–74 and ≥75 years). Rates of any adverse or drug-related adverse events were also similar across age groups. We conclude that the lipid efficacy and safety of ezetimibe and ezetimibe/statin in those aged 65–74 and 75 years and older are similar to those observed in patients aged under 65 years." @default.
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- W2149043451 date "2007-12-01" @default.
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- W2149043451 title "Efficacy and safety of ezetimibe and ezetimibe plus statin therapy in patients aged under 65, 65–74 and 75 years and older" @default.
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