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• W2149043555 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Jul 2001THE EFFECT OF SIMULATED BIRTH TRAUMA AND/OR OVARIECTOMY ON RODENT CONTINENCE MECHANISM. PART I: FUNCTIONAL AND STRUCTURAL CHANGE KARL-DIETRICH SIEVERT, MUSTAFA EMRE BAKIRCIOGLU, TONY TSAI, STEFAN E. DAHMS, LORA NUNES, and TOM F. LUE KARL-DIETRICH SIEVERTKARL-DIETRICH SIEVERT More articles by this author , MUSTAFA EMRE BAKIRCIOGLUMUSTAFA EMRE BAKIRCIOGLU More articles by this author , TONY TSAITONY TSAI More articles by this author , STEFAN E. DAHMSSTEFAN E. DAHMS More articles by this author , LORA NUNESLORA NUNES More articles by this author , and TOM F. LUETOM F. LUE More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)66151-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We examined the changes in the lower urinary tract after delivery, intravaginal ballooning and/or ovariectomy. Materials and Methods: The study included 10 virgin and 48 primiparous pregnant rats. Cystometry and the stress/sneeze test were performed in virgin and postpartum rats shortly after delivery and at 8 weeks before sacrifice. Half of the delivered animals underwent intravaginal balloon dilation. Four weeks later half in each group underwent ovariectomy. The rats were subdivided into group 1—delivery, group 2—delivery plus balloon inflation, group 3—delivery plus ovariectomy and group 4—delivery plus balloon inflation plus ovariectomy. Tissues from the bladder, bladder neck, urethra and levator were collected, analyzed by electron microscopy, and immunostained for caveolin-1, caveolin-3 and neuronal nitric oxide synthase. Results: Higher bladder capacity was detected in postpartum than in virgin rats. Urine leakage on stress/sneeze testing increased significantly in groups 2 and 4. Electron microscopy revealed a significant decrease in sarcolemma caveolae in the smooth muscle of the bladder and urethra in groups 2 to 4. In the bladder neck in group 3 caveolae were increased in smooth muscle. In groups 2 to 4 in the smooth muscle of the bladder and urethra caveolin-1 was significantly decreased. Caveolin-3 and neuronal nitric oxide synthase in striated muscle also significantly decreased in groups 2 to 4. Conclusions: These findings suggest that birth trauma simulated by ballooning and ovariectomy may contribute to stress urinary incontinence. The alteration in smooth muscle caveolae as well as the membrane protein caveolin may have a role in functional alterations caused by birth trauma and ovariectomy. References 1 : Incontinence in the female patient. J Fam Pract1982; 14: 935. Google Scholar 2 : Birth trauma: its effect on the urine continence mechanisms. Gynakol Geburtshilfl Rundsch1993; 33: 236. Google Scholar 3 : The effect of vaginal delivery on the urethral sphincter. Br J Obstet Gynaecol1988; 95: 142. Google Scholar 4 : [Female urinary incontinence. Which assessments? Which treatment?]. Ann Urol (Paris)1998; 32: 83. Google Scholar 5 : Abnormalities of the innervation of the urethral striated sphincter musculature in incontinence. Br J Urol1984; 56: 401. Google Scholar 6 : Damage to the innervation of the voluntary anal and periurethral sphincter musculature in incontinence: an electrophysiological study. J Neurol Neurosurg Psychiatry1984; 47: 1269. 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Identification of a novel caveolin scaffolding/inhibitory domain. J Biol Chem1997; 272: 28187. Google Scholar From the Departments of Urology and Obstetrics, Gynecology and Reproductive Sciences, University of California, School of Medicine, San Francisco, California, and Klinik und Poliklinik für Urologie, Westfälische Wilhelms-Universität Münster, Münster and Urologische Klinik and Poliklinik, Johannes-Gutenberg-University, Mainz, Germany© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byLenis A, Kuang M, Woo L, Hijaz A, Penn M, Butler R, Rackley R, Damaser M and Wood H (2018) Impact of Parturition on Chemokine Homing Factor Expression in the Vaginal Distention Model of Stress Urinary IncontinenceJournal of Urology, VOL. 189, NO. 4, (1588-1594), Online publication date: 1-Apr-2013.Hijaz A, Daneshgari F, Sievert K and Damaser M (2018) Animal Models of Female Stress Urinary IncontinenceJournal of Urology, VOL. 179, NO. 6, (2103-2110), Online publication date: 1-Jun-2008.Banie L, Lin G, Ning H, Wang G, Lue T and Lin C (2018) Effects of Estrogen, Raloxifene and Levormeloxifene on α1A-Adrenergic Receptor ExpressionJournal of Urology, VOL. 180, NO. 5, (2241-2246), Online publication date: 1-Nov-2008.Kamo I, Kaiho Y, Canon T, Chancellor M, de Groat W, Prantil R, Vorp D and Yoshimura N (2018) Functional Analysis of Active Urethral Closure Mechanisms Under Sneeze Induced Stress Condition in a Rat Model of Birth TraumaJournal of Urology, VOL. 176, NO. 6, (2711-2715), Online publication date: 1-Dec-2006. (2018) RE: FUNCTIONAL AND NEUROANATOMICAL EFFECTS OF VAGINAL DISTENTION AND PUDENDAL NERVE CRUSH IN THE FEMALE RAT: Reply by Authors.Journal of Urology, VOL. 171, NO. 6 Part 1, (2388-2389), Online publication date: 1-Jun-2004.ZHU Q, RESNICK N, ELBADAWI A and KUCHEL G (2018) Estrogen and Postnatal Maturation Increase Caveolar Number and Caveolin-1 Protein in Bladder Smooth Muscle CellsJournal of Urology, VOL. 171, NO. 1, (467-471), Online publication date: 1-Jan-2004.Osmonov D and Portillo F (2018) RE: FUNCTIONAL AND NEUROANATOMICAL EFFECTS OF VAGINAL DISTENTION AND PUDENDAL NERVE CRUSH IN THE FEMALE RATJournal of Urology, VOL. 171, NO. 6 Part 1, (2388-2388), Online publication date: 1-Jun-2004.DAMASER M, BROXTON-KING C, FERGUSON C, KIM F and KERNS J (2018) Functional and Neuroanatomical Effects of Vaginal Distention and Pudendal Nerve Crush in the Female RatJournal of Urology, VOL. 170, NO. 3, (1027-1031), Online publication date: 1-Sep-2003. Volume 166Issue 1July 2001Page: 311-317 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordspelvic floorlaborrats, Sprague-Dawleyurinary incontinence, stressbladderMetricsAuthor Information KARL-DIETRICH SIEVERT More articles by this author MUSTAFA EMRE BAKIRCIOGLU More articles by this author TONY TSAI More articles by this author STEFAN E. DAHMS More articles by this author LORA NUNES More articles by this author TOM F. LUE More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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