FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149051405> ?p ?o ?g. }

• W2149051405 endingPage "438" @default.
• W2149051405 startingPage "430" @default.
• W2149051405 abstract "Abstract Objectives The leaf decoctions of Tamarindus indica (TI) have long been traditionally used in liver ailments. The aim of this study was to investigate the anti-apoptotic activity of TI leaf extract against acute ethanol (EtOH)-induced liver injury. The major constituents of the extract were also examined for standardization purposes. Methods Rats (n = 5–7) were orally pretreated with TI leaf extract (25, 50 and 100 mg/kg) for seven days. Silymarin was used as a positive control. Liver tissue biochemical assays included key markers of apoptosis and its redox signalling. Serum enzyme levels were also determined. Key findings All graded doses of TI leaf extract mitigated the EtOH-induced liver caspase-3 activation (42, 57 and 64%) as well as DNA fragmentation (32, 47 and 50%), respectively. The highest dose of the extract demonstrated membrane-stabilizing (38%) in addition to glutathione-replenishing (88%) effects. Also, the leaves improved the liver histopathological alterations. Moreover, major plant bioactive polyphenolics, that might be responsible for the extract's observed effects, were isolated and identified. Conclusions TI leaf extract demonstrated promising anti-apoptotic hepatoprotective effects in rats. The use of TI leaves in different liver diseases, having apoptosis as the underlying pathology, hence warrants further clinical investigation." @default.
• W2149051405 created "2016-06-24" @default.
• W2149051405 creator A5020306270 @default.
• W2149051405 creator A5088590803 @default.
• W2149051405 date "2011-12-08" @default.
• W2149051405 modified "2023-10-11" @default.
• W2149051405 title "Anti-apoptotic effects of tamarind leaves against ethanol-induced rat liver injury†" @default.
• W2149051405 cites W150693630 @default.
• W2149051405 cites W1775749144 @default.
• W2149051405 cites W1965260442 @default.
• W2149051405 cites W1977178308 @default.
• W2149051405 cites W1980022907 @default.
• W2149051405 cites W1990373036 @default.
• W2149051405 cites W2004981017 @default.
• W2149051405 cites W2006370393 @default.
• W2149051405 cites W2015983285 @default.
• W2149051405 cites W2019800108 @default.
• W2149051405 cites W2020621917 @default.
• W2149051405 cites W2040542516 @default.
• W2149051405 cites W2053054955 @default.
• W2149051405 cites W2059844569 @default.
• W2149051405 cites W2060371040 @default.
• W2149051405 cites W2076944566 @default.
• W2149051405 cites W2081955952 @default.
• W2149051405 cites W2086959952 @default.
• W2149051405 cites W2110895652 @default.
• W2149051405 cites W2127185687 @default.
• W2149051405 cites W2139369955 @default.
• W2149051405 cites W2147525297 @default.
• W2149051405 cites W2154322840 @default.
• W2149051405 cites W2158950419 @default.
• W2149051405 cites W2263023695 @default.
• W2149051405 cites W4243104843 @default.
• W2149051405 doi "https://doi.org/10.1111/j.2042-7158.2011.01418.x" @default.
• W2149051405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22309275" @default.
• W2149051405 hasPublicationYear "2011" @default.
• W2149051405 type Work @default.
• W2149051405 sameAs 2149051405 @default.
• W2149051405 citedByCount "21" @default.
• W2149051405 countsByYear W21490514052012 @default.
• W2149051405 countsByYear W21490514052013 @default.
• W2149051405 countsByYear W21490514052014 @default.
• W2149051405 countsByYear W21490514052015 @default.
• W2149051405 countsByYear W21490514052016 @default.
• W2149051405 countsByYear W21490514052018 @default.
• W2149051405 countsByYear W21490514052019 @default.
• W2149051405 countsByYear W21490514052020 @default.
• W2149051405 countsByYear W21490514052021 @default.
• W2149051405 countsByYear W21490514052022 @default.
• W2149051405 countsByYear W21490514052023 @default.
• W2149051405 crossrefType "journal-article" @default.
• W2149051405 hasAuthorship W2149051405A5020306270 @default.
• W2149051405 hasAuthorship W2149051405A5088590803 @default.
• W2149051405 hasConcept C181199279 @default.
• W2149051405 hasConcept C185592680 @default.
• W2149051405 hasConcept C190283241 @default.
• W2149051405 hasConcept C190409667 @default.
• W2149051405 hasConcept C2776637226 @default.
• W2149051405 hasConcept C2778004101 @default.
• W2149051405 hasConcept C2780161600 @default.
• W2149051405 hasConcept C31573885 @default.
• W2149051405 hasConcept C43759708 @default.
• W2149051405 hasConcept C538909803 @default.
• W2149051405 hasConcept C55493867 @default.
• W2149051405 hasConcept C556039675 @default.
• W2149051405 hasConcept C70899900 @default.
• W2149051405 hasConcept C71924100 @default.
• W2149051405 hasConcept C86803240 @default.
• W2149051405 hasConcept C98274493 @default.
• W2149051405 hasConceptScore W2149051405C181199279 @default.
• W2149051405 hasConceptScore W2149051405C185592680 @default.
• W2149051405 hasConceptScore W2149051405C190283241 @default.
• W2149051405 hasConceptScore W2149051405C190409667 @default.
• W2149051405 hasConceptScore W2149051405C2776637226 @default.
• W2149051405 hasConceptScore W2149051405C2778004101 @default.
• W2149051405 hasConceptScore W2149051405C2780161600 @default.
• W2149051405 hasConceptScore W2149051405C31573885 @default.
• W2149051405 hasConceptScore W2149051405C43759708 @default.
• W2149051405 hasConceptScore W2149051405C538909803 @default.
• W2149051405 hasConceptScore W2149051405C55493867 @default.
• W2149051405 hasConceptScore W2149051405C556039675 @default.
• W2149051405 hasConceptScore W2149051405C70899900 @default.
• W2149051405 hasConceptScore W2149051405C71924100 @default.
• W2149051405 hasConceptScore W2149051405C86803240 @default.
• W2149051405 hasConceptScore W2149051405C98274493 @default.
• W2149051405 hasIssue "3" @default.
• W2149051405 hasLocation W21490514051 @default.
• W2149051405 hasLocation W21490514052 @default.
• W2149051405 hasOpenAccess W2149051405 @default.
• W2149051405 hasPrimaryLocation W21490514051 @default.
• W2149051405 hasRelatedWork W1606281722 @default.
• W2149051405 hasRelatedWork W2022297125 @default.
• W2149051405 hasRelatedWork W2039766976 @default.
• W2149051405 hasRelatedWork W2078530610 @default.
• W2149051405 hasRelatedWork W2163536072 @default.
• W2149051405 hasRelatedWork W2370007657 @default.
• W2149051405 hasRelatedWork W2416483595 @default.
• W2149051405 hasRelatedWork W2418788735 @default.

• next