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• W2149053203 abstract "IL-6 is a pleiotropic cytokine that participates in normal functions of the immune system, haematopoiesis, metabolism, as well as in the pathogenesis of metabolic and cardiovascular diseases. Both pro- and anti-inflammatory roles of IL-6 have been described, which are distinguished by different cascades of signalling transduction, namely classic and trans-signalling. The present review summarizes the basic principles of IL-6 signalling and discusses its roles in diabetes and associated cardiovascular complications, with emphasis on the different outcomes mediated by the two modes of IL-6 signalling and the value of developing therapeutic strategies to specifically target the deleterious trans-signalling of IL-6." @default.
• W2149053203 created "2016-06-24" @default.
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• W2149053203 creator A5057701274 @default.
• W2149053203 date "2014-07-17" @default.
• W2149053203 modified "2023-10-02" @default.
• W2149053203 title "IL-6 in diabetes and cardiovascular complications" @default.
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• W2149053203 doi "https://doi.org/10.1111/bph.12713" @default.
• W2149053203 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4128059" @default.
• W2149053203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24697653" @default.
• W2149053203 hasPublicationYear "2014" @default.
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