FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149074418> ?p ?o ?g. }

• W2149074418 endingPage "4019" @default.
• W2149074418 startingPage "4011" @default.
• W2149074418 abstract "Transcription of the Saccharomyces cerevisiae ARG1 gene is under the control of both positive and negative elements. Activation of the gene in minimal medium is induced by Gcn4. Repression occurs in the presence of arginine and requires the ArgR/Mcm1 complex that binds to two upstream arginine control (ARC) elements. With the recent finding that the E2 ubiquitin conjugase Rad6 modifies histone H2B, we examined the role of Rad6 in the regulation of ARG1 transcription. We find that Rad6 is required for repression of ARG1 in rich medium, with expression increased ∼10-fold in a rad6 null background. Chromatin immunoprecipitation analysis indicates increased binding of TATA-binding protein in the absence of Rad6. The active-site cysteine of Rad6 is required for repression, implicating ubiquitination in the process. The effects of Rad6 at ARG1 involve two components. In one of these, histone H2B is the likely target for ubiquitination by Rad6, since a strain expressing histone H2B with the principal ubiquitination site converted from lysine to arginine shows a fivefold relief of repression. The second component requires Ubr1 and thus likely the pathway of N-end rule degradation. Through the analysis of promoter constructs with ARC deleted and an arg80 rad6 double mutant, we show that Rad6 repression is mediated through the ArgR/Mcm1 complex. In addition, analysis of an ada2 rad6 deletion strain indicated that the SAGA acetyltransferase complex and Rad6 act in the same pathway to repress ARG1 in rich medium." @default.
• W2149074418 created "2016-06-24" @default.
• W2149074418 creator A5020938159 @default.
• W2149074418 creator A5026215636 @default.
• W2149074418 creator A5058062258 @default.
• W2149074418 creator A5061095336 @default.
• W2149074418 creator A5069798755 @default.
• W2149074418 creator A5075311799 @default.
• W2149074418 date "2002-06-01" @default.
• W2149074418 modified "2023-09-27" @default.
• W2149074418 title "The E2 Ubiquitin Conjugase Rad6 Is Required for the ArgR/Mcm1 Repression of<i>ARG1</i>Transcription" @default.
• W2149074418 cites W1502616762 @default.
• W2149074418 cites W1528395683 @default.
• W2149074418 cites W1534277217 @default.
• W2149074418 cites W1553415829 @default.
• W2149074418 cites W1559325314 @default.
• W2149074418 cites W1561767449 @default.
• W2149074418 cites W1585503692 @default.
• W2149074418 cites W1609966422 @default.
• W2149074418 cites W1739064941 @default.
• W2149074418 cites W1839206272 @default.
• W2149074418 cites W1862915326 @default.
• W2149074418 cites W1867485935 @default.
• W2149074418 cites W1930862941 @default.
• W2149074418 cites W1966042070 @default.
• W2149074418 cites W1967270377 @default.
• W2149074418 cites W1968005064 @default.
• W2149074418 cites W1977188840 @default.
• W2149074418 cites W1999406663 @default.
• W2149074418 cites W2002103750 @default.
• W2149074418 cites W2009563640 @default.
• W2149074418 cites W2011580988 @default.
• W2149074418 cites W2013289317 @default.
• W2149074418 cites W2028096667 @default.
• W2149074418 cites W2036298138 @default.
• W2149074418 cites W2037579319 @default.
• W2149074418 cites W2040073289 @default.
• W2149074418 cites W2043641522 @default.
• W2149074418 cites W2044233617 @default.
• W2149074418 cites W2046678844 @default.
• W2149074418 cites W2047050750 @default.
• W2149074418 cites W2050432515 @default.
• W2149074418 cites W2056079473 @default.
• W2149074418 cites W2064850779 @default.
• W2149074418 cites W2070801275 @default.
• W2149074418 cites W2070988542 @default.
• W2149074418 cites W2075134962 @default.
• W2149074418 cites W2076562349 @default.
• W2149074418 cites W2081436061 @default.
• W2149074418 cites W2088890872 @default.
• W2149074418 cites W2095771622 @default.
• W2149074418 cites W2096881442 @default.
• W2149074418 cites W2100443229 @default.
• W2149074418 cites W2101101375 @default.
• W2149074418 cites W2103995020 @default.
• W2149074418 cites W2107915635 @default.
• W2149074418 cites W2108625845 @default.
• W2149074418 cites W2109998847 @default.
• W2149074418 cites W2110992142 @default.
• W2149074418 cites W2121586065 @default.
• W2149074418 cites W2140948740 @default.
• W2149074418 cites W2147921405 @default.
• W2149074418 cites W2155488587 @default.
• W2149074418 cites W2156681215 @default.
• W2149074418 cites W2167389868 @default.
• W2149074418 cites W2170939558 @default.
• W2149074418 cites W2214383802 @default.
• W2149074418 cites W2418361432 @default.
• W2149074418 cites W2979052501 @default.
• W2149074418 cites W3087720232 @default.
• W2149074418 cites W4239029175 @default.
• W2149074418 cites W4255262265 @default.
• W2149074418 cites W4361866883 @default.
• W2149074418 cites W68591885 @default.
• W2149074418 cites W958055355 @default.
• W2149074418 doi "https://doi.org/10.1128/mcb.22.12.4011-4019.2002" @default.
• W2149074418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/133851" @default.
• W2149074418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12024015" @default.
• W2149074418 hasPublicationYear "2002" @default.
• W2149074418 type Work @default.
• W2149074418 sameAs 2149074418 @default.
• W2149074418 citedByCount "45" @default.
• W2149074418 countsByYear W21490744182012 @default.
• W2149074418 countsByYear W21490744182013 @default.
• W2149074418 countsByYear W21490744182014 @default.
• W2149074418 countsByYear W21490744182015 @default.
• W2149074418 countsByYear W21490744182016 @default.
• W2149074418 countsByYear W21490744182020 @default.
• W2149074418 countsByYear W21490744182021 @default.
• W2149074418 countsByYear W21490744182022 @default.
• W2149074418 crossrefType "journal-article" @default.
• W2149074418 hasAuthorship W2149074418A5020938159 @default.
• W2149074418 hasAuthorship W2149074418A5026215636 @default.
• W2149074418 hasAuthorship W2149074418A5058062258 @default.
• W2149074418 hasAuthorship W2149074418A5061095336 @default.
• W2149074418 hasAuthorship W2149074418A5069798755 @default.
• W2149074418 hasAuthorship W2149074418A5075311799 @default.
• W2149074418 hasBestOaLocation W21490744181 @default.

• next