FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149078110> ?p ?o ?g. }

• W2149078110 endingPage "47" @default.
• W2149078110 startingPage "39" @default.
• W2149078110 abstract "PTEN gene inactivation by mutation or deletion is common in pediatric T-cell acute lymphoblastic leukemia (T-ALL), but the impact on outcome is unclear, particularly in patients with NOTCH1/FBXW7 mutations. We screened samples from 145 patients treated on the MRC UKALL2003 trial for PTEN mutations using heteroduplex analysis and gene deletions using single nucleotide polymorphism arrays, and related genotype to response to therapy and long-term outcome. PTEN loss-of-function mutations/gene deletions were detected in 22% (PTEN(ABN)). Quantification of mutant level indicated that 67% of mutated cases harbored more than one mutant, with up to four mutants detected, consistent with the presence of multiple leukemic sub-clones. Overall, 41% of PTEN(ABN) cases were considered to have biallelic abnormalities (mutation and/or deletion) with complete loss of PTEN in a proportion of cells. In addition, 9% of cases had N- or K-RAS mutations. Neither PTEN nor RAS genotype significantly impacted on response to therapy or long-term outcome, irrespective of mutant level, and there was no evidence that they changed the highly favorable outcome of patients with double NOTCH1/FBXW7 mutations. These results indicate that, for pediatric patients treated according to current protocols, routine screening for PTEN or RAS abnormalities at diagnosis is not warranted to further refine risk stratification." @default.
• W2149078110 created "2016-06-24" @default.
• W2149078110 creator A5005708709 @default.
• W2149078110 creator A5018708168 @default.
• W2149078110 creator A5057908266 @default.
• W2149078110 creator A5059445192 @default.
• W2149078110 creator A5066319509 @default.
• W2149078110 creator A5066362816 @default.
• W2149078110 date "2015-07-29" @default.
• W2149078110 modified "2023-10-16" @default.
• W2149078110 title "Impact of PTEN abnormalities on outcome in pediatric patients with T-cell acute lymphoblastic leukemia treated on the MRC UKALL2003 trial" @default.
• W2149078110 cites W1976171159 @default.
• W2149078110 cites W1979608361 @default.
• W2149078110 cites W1982395176 @default.
• W2149078110 cites W1982767015 @default.
• W2149078110 cites W1983393070 @default.
• W2149078110 cites W1984065010 @default.
• W2149078110 cites W1988877817 @default.
• W2149078110 cites W1992477322 @default.
• W2149078110 cites W1995421851 @default.
• W2149078110 cites W1995995993 @default.
• W2149078110 cites W1996222881 @default.
• W2149078110 cites W1999125576 @default.
• W2149078110 cites W2003307365 @default.
• W2149078110 cites W2018769121 @default.
• W2149078110 cites W2048983861 @default.
• W2149078110 cites W2049396238 @default.
• W2149078110 cites W2053224053 @default.
• W2149078110 cites W2053820532 @default.
• W2149078110 cites W2060383229 @default.
• W2149078110 cites W2060605982 @default.
• W2149078110 cites W2071268727 @default.
• W2149078110 cites W2073345709 @default.
• W2149078110 cites W2074517075 @default.
• W2149078110 cites W2075291089 @default.
• W2149078110 cites W2076584338 @default.
• W2149078110 cites W2080122247 @default.
• W2149078110 cites W2087320673 @default.
• W2149078110 cites W2096743264 @default.
• W2149078110 cites W2130867651 @default.
• W2149078110 cites W2137042680 @default.
• W2149078110 cites W2140154966 @default.
• W2149078110 cites W2141869972 @default.
• W2149078110 cites W2143364167 @default.
• W2149078110 cites W2144051719 @default.
• W2149078110 cites W2150629538 @default.
• W2149078110 cites W2158284820 @default.
• W2149078110 cites W2160807638 @default.
• W2149078110 cites W2164603747 @default.
• W2149078110 doi "https://doi.org/10.1038/leu.2015.206" @default.
• W2149078110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4705426" @default.
• W2149078110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26220040" @default.
• W2149078110 hasPublicationYear "2015" @default.
• W2149078110 type Work @default.
• W2149078110 sameAs 2149078110 @default.
• W2149078110 citedByCount "61" @default.
• W2149078110 countsByYear W21490781102015 @default.
• W2149078110 countsByYear W21490781102016 @default.
• W2149078110 countsByYear W21490781102017 @default.
• W2149078110 countsByYear W21490781102018 @default.
• W2149078110 countsByYear W21490781102019 @default.
• W2149078110 countsByYear W21490781102020 @default.
• W2149078110 countsByYear W21490781102021 @default.
• W2149078110 countsByYear W21490781102022 @default.
• W2149078110 countsByYear W21490781102023 @default.
• W2149078110 crossrefType "journal-article" @default.
• W2149078110 hasAuthorship W2149078110A5005708709 @default.
• W2149078110 hasAuthorship W2149078110A5018708168 @default.
• W2149078110 hasAuthorship W2149078110A5057908266 @default.
• W2149078110 hasAuthorship W2149078110A5059445192 @default.
• W2149078110 hasAuthorship W2149078110A5066319509 @default.
• W2149078110 hasAuthorship W2149078110A5066362816 @default.
• W2149078110 hasBestOaLocation W21490781101 @default.
• W2149078110 hasConcept C104317684 @default.
• W2149078110 hasConcept C135763542 @default.
• W2149078110 hasConcept C143065580 @default.
• W2149078110 hasConcept C190283241 @default.
• W2149078110 hasConcept C2777609662 @default.
• W2149078110 hasConcept C501734568 @default.
• W2149078110 hasConcept C502942594 @default.
• W2149078110 hasConcept C54355233 @default.
• W2149078110 hasConcept C86554907 @default.
• W2149078110 hasConcept C86803240 @default.
• W2149078110 hasConceptScore W2149078110C104317684 @default.
• W2149078110 hasConceptScore W2149078110C135763542 @default.
• W2149078110 hasConceptScore W2149078110C143065580 @default.
• W2149078110 hasConceptScore W2149078110C190283241 @default.
• W2149078110 hasConceptScore W2149078110C2777609662 @default.
• W2149078110 hasConceptScore W2149078110C501734568 @default.
• W2149078110 hasConceptScore W2149078110C502942594 @default.
• W2149078110 hasConceptScore W2149078110C54355233 @default.
• W2149078110 hasConceptScore W2149078110C86554907 @default.
• W2149078110 hasConceptScore W2149078110C86803240 @default.
• W2149078110 hasIssue "1" @default.
• W2149078110 hasLocation W21490781101 @default.
• W2149078110 hasLocation W21490781102 @default.
• W2149078110 hasLocation W21490781103 @default.
• W2149078110 hasLocation W21490781104 @default.

• next