Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149078229> ?p ?o ?g. }
- W2149078229 abstract "Cells maintain intracellular pH (pHi) within a narrow range (7.1-7.2) by controlling membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH sensors. These sensors have the ability to recognize and induce cellular responses to maintain the intracellular pH, often at the expense of acidifying the extracellular pH. In turn, extracellular acidification impacts cells via specific acid-sensing ion channels (ASICs) and proton-sensing G-protein coupled receptors (GPCRs). In this review, we will discuss some of the major players in proton sensing at the plasma membrane and their downstream consequences in cancer cells and how these pH-mediated changes affect processes such as migration and metastasis. The complex mechanisms by which they transduce acid pH signals to the cytoplasm and nucleus are not well understood. However, there is evidence that expression of proton-sensing GPCRs such as GPR4, TDAG8, and OGR1 can regulate aspects of tumorigenesis and invasion, including colfilin and talin regulated actin (de-)polymerization. Major mechanisms for maintenance of pHi homeostasis include monocarboxylate, bicarbonate and proton transporters. Notably, there is little evidence suggesting a link between their activities and those of the extracellular H+-sensors, suggesting a mechanistic disconnect between intra- and extra-cellular pH. Understanding the mechanisms of pH sensing and regulation may lead to novel and informed therapeutic strategies that can target acidosis, a common physical hallmark of solid tumors." @default.
- W2149078229 created "2016-06-24" @default.
- W2149078229 creator A5026838871 @default.
- W2149078229 creator A5028810747 @default.
- W2149078229 creator A5082346230 @default.
- W2149078229 date "2013-01-01" @default.
- W2149078229 modified "2023-10-12" @default.
- W2149078229 title "pH sensing and regulation in cancer" @default.
- W2149078229 cites W106703604 @default.
- W2149078229 cites W1521516049 @default.
- W2149078229 cites W1571606995 @default.
- W2149078229 cites W1583356175 @default.
- W2149078229 cites W1703082451 @default.
- W2149078229 cites W1770277884 @default.
- W2149078229 cites W1817095747 @default.
- W2149078229 cites W1829737408 @default.
- W2149078229 cites W1836647274 @default.
- W2149078229 cites W1964027175 @default.
- W2149078229 cites W1964252660 @default.
- W2149078229 cites W1966422114 @default.
- W2149078229 cites W1968952749 @default.
- W2149078229 cites W1971078428 @default.
- W2149078229 cites W1971394915 @default.
- W2149078229 cites W1973286318 @default.
- W2149078229 cites W1974740818 @default.
- W2149078229 cites W1978314682 @default.
- W2149078229 cites W1979564359 @default.
- W2149078229 cites W1982019397 @default.
- W2149078229 cites W1982910988 @default.
- W2149078229 cites W1983217073 @default.
- W2149078229 cites W1984234802 @default.
- W2149078229 cites W1988739433 @default.
- W2149078229 cites W1992409982 @default.
- W2149078229 cites W1995699249 @default.
- W2149078229 cites W1999707554 @default.
- W2149078229 cites W2002923467 @default.
- W2149078229 cites W2007995664 @default.
- W2149078229 cites W2008068321 @default.
- W2149078229 cites W2011842971 @default.
- W2149078229 cites W2013130960 @default.
- W2149078229 cites W2013711061 @default.
- W2149078229 cites W2015292102 @default.
- W2149078229 cites W2015620660 @default.
- W2149078229 cites W2017007251 @default.
- W2149078229 cites W2018095250 @default.
- W2149078229 cites W2030240898 @default.
- W2149078229 cites W2030439340 @default.
- W2149078229 cites W2031670167 @default.
- W2149078229 cites W2032635767 @default.
- W2149078229 cites W2036667953 @default.
- W2149078229 cites W2037945929 @default.
- W2149078229 cites W2040340572 @default.
- W2149078229 cites W2042285105 @default.
- W2149078229 cites W2047521631 @default.
- W2149078229 cites W2047569309 @default.
- W2149078229 cites W2048296596 @default.
- W2149078229 cites W2049584121 @default.
- W2149078229 cites W2051611091 @default.
- W2149078229 cites W2055769271 @default.
- W2149078229 cites W2056261267 @default.
- W2149078229 cites W2056582953 @default.
- W2149078229 cites W2057690410 @default.
- W2149078229 cites W2059249920 @default.
- W2149078229 cites W2059492700 @default.
- W2149078229 cites W2061100459 @default.
- W2149078229 cites W2063082738 @default.
- W2149078229 cites W2066520032 @default.
- W2149078229 cites W2066856305 @default.
- W2149078229 cites W2067008989 @default.
- W2149078229 cites W2068050569 @default.
- W2149078229 cites W2070355658 @default.
- W2149078229 cites W2071807850 @default.
- W2149078229 cites W2073771554 @default.
- W2149078229 cites W2073803242 @default.
- W2149078229 cites W2075776055 @default.
- W2149078229 cites W2078684128 @default.
- W2149078229 cites W2079906226 @default.
- W2149078229 cites W2081827914 @default.
- W2149078229 cites W2082024168 @default.
- W2149078229 cites W2082483448 @default.
- W2149078229 cites W2084441235 @default.
- W2149078229 cites W2085805107 @default.
- W2149078229 cites W2086036081 @default.
- W2149078229 cites W2087176518 @default.
- W2149078229 cites W2087216698 @default.
- W2149078229 cites W2087226541 @default.
- W2149078229 cites W2097695105 @default.
- W2149078229 cites W2099040856 @default.
- W2149078229 cites W2099595411 @default.
- W2149078229 cites W2108521165 @default.
- W2149078229 cites W2109493256 @default.
- W2149078229 cites W2110335843 @default.
- W2149078229 cites W2115732451 @default.
- W2149078229 cites W2116130782 @default.
- W2149078229 cites W2119746112 @default.
- W2149078229 cites W2122608403 @default.
- W2149078229 cites W2122927946 @default.
- W2149078229 cites W2124360996 @default.
- W2149078229 cites W2124735791 @default.
- W2149078229 cites W2124903948 @default.