FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149081105> ?p ?o ?g. }

• W2149081105 abstract "Translocator protein (18 kDa; TSPO) is a mitochondrial cholesterol- and drug-binding protein involved in cholesterol import into mitochondria, the rate-limiting step in steroidogenesis. TSPO is expressed at high levels in Leydig cells of the testis, and its expression levels dictate the ability of the cells to form androgen. In search of mechanisms that regulate Tspo expression, a number of transcription factors acting on its promoter region have been identified. We report herein the presence of a mechanism of regulation of Tspo expression via complementation with a natural antisense transcript (NAT). At the Tspo locus, a short interspersed repetitive element (SINE) of the SINE B2 family has the potential for high transcriptional activity. The extension of the SINE B2 element-mediated transcript overlapped with exon 3 of the Tspo gene and formed a NAT specific for Tspo (Tspo-NAT) in MA-10 mouse tumor Leydig cells. The identified Tspo-NAT was also found in testis and kidney tissues. Overexpression of the Tspo-NAT regulated Tspo gene expression and its function in steroid formation in MA-10 cells. Time-course studies have indicated that Tspo-NAT expression is regulated by cAMP and could regulate TSPO levels to maintain optimal steroid production by MA-10 Leydig cells. Taken together, these results suggest a new micro-transcriptional mechanism that regulates Tspo expression and thus steroidogenesis via an intron-based SINE B2-driven NAT specific for the Tspo gene." @default.
• W2149081105 created "2016-06-24" @default.
• W2149081105 creator A5016102256 @default.
• W2149081105 creator A5058801218 @default.
• W2149081105 date "2012-05-01" @default.
• W2149081105 modified "2023-09-26" @default.
• W2149081105 title "Transcriptional Regulation of Translocator Protein (Tspo) via a SINE B2-Mediated Natural Antisense Transcript in MA-10 Leydig Cells1" @default.
• W2149081105 cites W1966541444 @default.
• W2149081105 cites W1968273294 @default.
• W2149081105 cites W1969614150 @default.
• W2149081105 cites W1971229919 @default.
• W2149081105 cites W1973027560 @default.
• W2149081105 cites W1976060898 @default.
• W2149081105 cites W1979662111 @default.
• W2149081105 cites W1981170261 @default.
• W2149081105 cites W1984768408 @default.
• W2149081105 cites W1985582783 @default.
• W2149081105 cites W1999924432 @default.
• W2149081105 cites W2003294710 @default.
• W2149081105 cites W2003800568 @default.
• W2149081105 cites W2007262329 @default.
• W2149081105 cites W2010353182 @default.
• W2149081105 cites W2025794959 @default.
• W2149081105 cites W2026805262 @default.
• W2149081105 cites W2027593690 @default.
• W2149081105 cites W2028010103 @default.
• W2149081105 cites W2032710318 @default.
• W2149081105 cites W2033818560 @default.
• W2149081105 cites W2034450620 @default.
• W2149081105 cites W2037456901 @default.
• W2149081105 cites W2040356607 @default.
• W2149081105 cites W2047285578 @default.
• W2149081105 cites W2048447535 @default.
• W2149081105 cites W2048863091 @default.
• W2149081105 cites W2050426121 @default.
• W2149081105 cites W2050764050 @default.
• W2149081105 cites W2055699536 @default.
• W2149081105 cites W2059884965 @default.
• W2149081105 cites W2066827579 @default.
• W2149081105 cites W2075639945 @default.
• W2149081105 cites W2076945625 @default.
• W2149081105 cites W2085350682 @default.
• W2149081105 cites W2086815111 @default.
• W2149081105 cites W2097329828 @default.
• W2149081105 cites W2097493491 @default.
• W2149081105 cites W2099741455 @default.
• W2149081105 cites W2102350332 @default.
• W2149081105 cites W2126081274 @default.
• W2149081105 cites W2130749372 @default.
• W2149081105 cites W2130886644 @default.
• W2149081105 cites W2134397312 @default.
• W2149081105 cites W2142761929 @default.
• W2149081105 cites W2143362788 @default.
• W2149081105 cites W2144253115 @default.
• W2149081105 cites W2154241726 @default.
• W2149081105 cites W2154916602 @default.
• W2149081105 cites W2169898794 @default.
• W2149081105 cites W2224938033 @default.
• W2149081105 cites W2471094282 @default.
• W2149081105 doi "https://doi.org/10.1095/biolreprod.111.097535" @default.
• W2149081105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3364927" @default.
• W2149081105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22378763" @default.
• W2149081105 hasPublicationYear "2012" @default.
• W2149081105 type Work @default.
• W2149081105 sameAs 2149081105 @default.
• W2149081105 citedByCount "14" @default.
• W2149081105 countsByYear W21490811052013 @default.
• W2149081105 countsByYear W21490811052014 @default.
• W2149081105 countsByYear W21490811052016 @default.
• W2149081105 countsByYear W21490811052017 @default.
• W2149081105 countsByYear W21490811052019 @default.
• W2149081105 countsByYear W21490811052021 @default.
• W2149081105 crossrefType "journal-article" @default.
• W2149081105 hasAuthorship W2149081105A5016102256 @default.
• W2149081105 hasAuthorship W2149081105A5058801218 @default.
• W2149081105 hasBestOaLocation W21490811051 @default.
• W2149081105 hasConcept C104317684 @default.
• W2149081105 hasConcept C138885662 @default.
• W2149081105 hasConcept C150194340 @default.
• W2149081105 hasConcept C153911025 @default.
• W2149081105 hasConcept C179926584 @default.
• W2149081105 hasConcept C203014093 @default.
• W2149081105 hasConcept C2776791281 @default.
• W2149081105 hasConcept C2776914184 @default.
• W2149081105 hasConcept C41895202 @default.
• W2149081105 hasConcept C54355233 @default.
• W2149081105 hasConcept C86803240 @default.
• W2149081105 hasConcept C87753298 @default.
• W2149081105 hasConcept C95444343 @default.
• W2149081105 hasConceptScore W2149081105C104317684 @default.
• W2149081105 hasConceptScore W2149081105C138885662 @default.
• W2149081105 hasConceptScore W2149081105C150194340 @default.
• W2149081105 hasConceptScore W2149081105C153911025 @default.
• W2149081105 hasConceptScore W2149081105C179926584 @default.
• W2149081105 hasConceptScore W2149081105C203014093 @default.
• W2149081105 hasConceptScore W2149081105C2776791281 @default.
• W2149081105 hasConceptScore W2149081105C2776914184 @default.
• W2149081105 hasConceptScore W2149081105C41895202 @default.
• W2149081105 hasConceptScore W2149081105C54355233 @default.
• W2149081105 hasConceptScore W2149081105C86803240 @default.

• next