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- W2149081590 abstract "ABSTRACT Chlamydia trachomatis is the most common sexually transmitted bacterial infection in the United States. Utilizing cloned murine oviduct epithelial cell lines, we previously identified Toll-like receptor 2 (TLR2) as the principal epithelial pattern recognition receptor (PRR) for infection-triggered release of the acute inflammatory cytokines interleukin-6 and granulocyte-macrophage colony-stimulating factor. The infected oviduct epithelial cell lines also secreted the immunomodulatory cytokine beta interferon (IFN-β) in a largely MyD88-independent manner. Although TLR3 was the only IFN-β production-capable TLR expressed by the oviduct cell lines, we were not able to determine whether TLR3 was responsible for IFN-β production because the epithelial cells were unresponsive to the TLR3 ligand poly(I-C), and small interfering RNA (siRNA) techniques were ineffective at knocking down TLR3 expression. To further investigate the potential role of TLR3 in the infected epithelial cell secretion of IFN-β, we examined the roles of its downstream signaling molecules TRIF and IFN regulatory factor 3 (IRF-3) using a dominant-negative TRIF molecule and siRNA specific for TRIF and IRF-3. Antagonism of either IRF-3 or TRIF signaling significantly decreased IFN-β production. These data implicate TLR3, or an unknown PRR utilizing TRIF, as the source of IFN-β production by Chlamydia -infected oviduct epithelial cells." @default.
- W2149081590 created "2016-06-24" @default.
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- W2149081590 date "2007-03-01" @default.
- W2149081590 modified "2023-10-17" @default.
- W2149081590 title "<i>Chlamydia muridarum</i>Infection Elicits a Beta Interferon Response in Murine Oviduct Epithelial Cells Dependent on Interferon Regulatory Factor 3 and TRIF" @default.
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- W2149081590 doi "https://doi.org/10.1128/iai.01525-06" @default.
- W2149081590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1828549" @default.
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