Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149084874> ?p ?o ?g. }
- W2149084874 endingPage "205" @default.
- W2149084874 startingPage "195" @default.
- W2149084874 abstract "Adenosine levels in oxygen-deprived myocardium can rise to 10- 100 microM concentrations known to cause atrioventricular (AV) conduction delay and block. We reported that the AV conduction delay and block caused by hypoxia is markedly attenuated by 10 microM aminophylline, and adenosine competitive antagonist. THe purpose of the present study was to investigate adenosine's role in ischemic AV conduction disturbances. Dogs were anesthetized and instrumented for His bundle and surface electrogram recordings. The total AV conduction time was subdivided in to atrial-His bundle (AH) and His bundle-ventricle intervals. The atrioventricular node artery (AVNA) was cannulated for selective injection of drugs in the AV node region. Adenosine (10 to 100 microgram), as a 2-ml bolus injection, rapidly produced a dose-dependent, transient increase in the AH interval; a 1,000-microgram dose caused second degree AV block. The duration of the increase in AH interval was also dose-dependent. Dipyridamole, and inhibitor of nucleoside transport, potentiated the negative dromotropic effects of adenosine, whereas aminophylline attenuated them. In some dogs, after cannulation of the AVNA, first and second degree AV block occurred spontaneously or were induced by rapid atrial pacing. Injection of the aminophylline (5 mg/kg, i.e.) or theophylline (100-1,000 microgram) into the AVNA rapidly reversed the AV blocks. Upon washout of the drugs the AV blocks recurred. We conclude that endogenously released adenosine may account for a major fraction of the AV conduction delay and block associated with impaired blood supply to the AV node, and the theophylline and aminophylline reverse the AV conduction defect by antagonizing the effects of adenosine." @default.
- W2149084874 created "2016-06-24" @default.
- W2149084874 creator A5011434207 @default.
- W2149084874 creator A5016568391 @default.
- W2149084874 creator A5025994503 @default.
- W2149084874 date "1981-07-01" @default.
- W2149084874 modified "2023-10-17" @default.
- W2149084874 title "Evidence for adenosine mediation of atrioventricular block in the ischemic canine myocardium." @default.
- W2149084874 cites W118543573 @default.
- W2149084874 cites W1602784471 @default.
- W2149084874 cites W1974173187 @default.
- W2149084874 cites W1975288080 @default.
- W2149084874 cites W1980848908 @default.
- W2149084874 cites W1991975135 @default.
- W2149084874 cites W1992435167 @default.
- W2149084874 cites W1993963788 @default.
- W2149084874 cites W2000989410 @default.
- W2149084874 cites W2011539902 @default.
- W2149084874 cites W2012861887 @default.
- W2149084874 cites W2021798413 @default.
- W2149084874 cites W2031228029 @default.
- W2149084874 cites W2035962819 @default.
- W2149084874 cites W2038204666 @default.
- W2149084874 cites W2041227911 @default.
- W2149084874 cites W2049327772 @default.
- W2149084874 cites W2064630331 @default.
- W2149084874 cites W2069223719 @default.
- W2149084874 cites W2073265481 @default.
- W2149084874 cites W2079337335 @default.
- W2149084874 cites W2106383373 @default.
- W2149084874 cites W2113347445 @default.
- W2149084874 cites W2145671207 @default.
- W2149084874 cites W2157958680 @default.
- W2149084874 cites W2272330384 @default.
- W2149084874 cites W2332552596 @default.
- W2149084874 cites W2339175250 @default.
- W2149084874 cites W2411497963 @default.
- W2149084874 cites W2412857863 @default.
- W2149084874 cites W2436330965 @default.
- W2149084874 cites W2438692934 @default.
- W2149084874 cites W2464935120 @default.
- W2149084874 cites W2468976953 @default.
- W2149084874 cites W2398519766 @default.
- W2149084874 doi "https://doi.org/10.1172/jci110235" @default.
- W2149084874 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/370787" @default.
- W2149084874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7251860" @default.
- W2149084874 hasPublicationYear "1981" @default.
- W2149084874 type Work @default.
- W2149084874 sameAs 2149084874 @default.
- W2149084874 citedByCount "71" @default.
- W2149084874 countsByYear W21490848742012 @default.
- W2149084874 countsByYear W21490848742013 @default.
- W2149084874 countsByYear W21490848742014 @default.
- W2149084874 countsByYear W21490848742015 @default.
- W2149084874 countsByYear W21490848742017 @default.
- W2149084874 countsByYear W21490848742019 @default.
- W2149084874 countsByYear W21490848742020 @default.
- W2149084874 countsByYear W21490848742021 @default.
- W2149084874 crossrefType "journal-article" @default.
- W2149084874 hasAuthorship W2149084874A5011434207 @default.
- W2149084874 hasAuthorship W2149084874A5016568391 @default.
- W2149084874 hasAuthorship W2149084874A5025994503 @default.
- W2149084874 hasBestOaLocation W21490848741 @default.
- W2149084874 hasConcept C126322002 @default.
- W2149084874 hasConcept C164705383 @default.
- W2149084874 hasConcept C178697064 @default.
- W2149084874 hasConcept C2776024998 @default.
- W2149084874 hasConcept C2776202631 @default.
- W2149084874 hasConcept C2776991684 @default.
- W2149084874 hasConcept C2777953023 @default.
- W2149084874 hasConcept C2778095195 @default.
- W2149084874 hasConcept C2778921608 @default.
- W2149084874 hasConcept C2780283014 @default.
- W2149084874 hasConcept C42219234 @default.
- W2149084874 hasConcept C71924100 @default.
- W2149084874 hasConcept C84393581 @default.
- W2149084874 hasConceptScore W2149084874C126322002 @default.
- W2149084874 hasConceptScore W2149084874C164705383 @default.
- W2149084874 hasConceptScore W2149084874C178697064 @default.
- W2149084874 hasConceptScore W2149084874C2776024998 @default.
- W2149084874 hasConceptScore W2149084874C2776202631 @default.
- W2149084874 hasConceptScore W2149084874C2776991684 @default.
- W2149084874 hasConceptScore W2149084874C2777953023 @default.
- W2149084874 hasConceptScore W2149084874C2778095195 @default.
- W2149084874 hasConceptScore W2149084874C2778921608 @default.
- W2149084874 hasConceptScore W2149084874C2780283014 @default.
- W2149084874 hasConceptScore W2149084874C42219234 @default.
- W2149084874 hasConceptScore W2149084874C71924100 @default.
- W2149084874 hasConceptScore W2149084874C84393581 @default.
- W2149084874 hasIssue "1" @default.
- W2149084874 hasLocation W21490848741 @default.
- W2149084874 hasLocation W21490848742 @default.
- W2149084874 hasLocation W21490848743 @default.
- W2149084874 hasLocation W21490848744 @default.
- W2149084874 hasOpenAccess W2149084874 @default.
- W2149084874 hasPrimaryLocation W21490848741 @default.
- W2149084874 hasRelatedWork W117170742 @default.
- W2149084874 hasRelatedWork W1968457284 @default.