FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149086311> ?p ?o ?g. }

• W2149086311 endingPage "186" @default.
• W2149086311 startingPage "177" @default.
• W2149086311 abstract "Objective: We analyzed the role of transforming growth factor-beta (TGF-β), a fibrogenic cytokine, in the development of left ventricular diastolic dysfunction following heart transplantation. Methods: We studied 152 heart transplant recipients who had survived for at least 24 months. We compared histopathological findings (staining of endomyocardial biopsy specimens using Heamatoxlin Eosin and polyclonal antibodies), left ventricular function (Doppler echocardiography) and clinical course (NYHA status}. Patients are classified into group A (n=56 recipients) with immunohistochemical TGF-β staining score >7 and group B (n=96 recipients) with a staining score <7. Results: Doppler echocardiographic evaluation demonstrated greater impairment of left ventricular diastolic function in recipients with higher TGF-β staining score. The average mitral deceleration time was 129±6 ms for recipients group A compared to 167±15 ms in group B. While the mean isovolumic relaxation time was 65±8 ms for patients in group A compared with 82±6 ms for recipients in group B (P=0.0004 and 0.005, respectively). Immunohistochemical scoring correlated inversely with both mitral deceleration and isovolumic relaxation times (r=−0.74, P=0.0004 and r=−0.66, P=0.004, respectively). Mean NYHA status was 2.7±1.3 for group A compared to 1.17±0.4 in group B was (P=0.002). Five years follow-up revealed persistent left ventricular diastolic impairment for recipients with higher immunohistochemical staining score. Mitral deceleration time and isovolumic relaxation time were 118±11 and 62±7 ms for group A compared to 156±12 and 80±5 ms for group B, P=0.006 and P=0.01, respectively. The actuarial development of subsequent coronary artery disease (> 50% stenosis) was 17 and 29% for recipients in group A compared to 4 and 6% for recipients in group B at 3 and 5 years follow-up, respectively (P=0.01 and P=0.005, respectively). Conclusions: TGF-β expression in cardiac allografts is associated with impaired graft function and limited survival. The pathogenesis of diastolic dysfunction may be an aberrant repair process following rejection due to increased TGF-β expression in transplant recipients." @default.
• W2149086311 created "2016-06-24" @default.
• W2149086311 creator A5018736252 @default.
• W2149086311 creator A5021403561 @default.
• W2149086311 creator A5024727740 @default.
• W2149086311 creator A5029942292 @default.
• W2149086311 creator A5072252590 @default.
• W2149086311 creator A5073446648 @default.
• W2149086311 date "2001-07-01" @default.
• W2149086311 modified "2023-09-23" @default.
• W2149086311 title "Transforming growth factor beta and myocardial dysfunction following heart transplantation" @default.
• W2149086311 cites W127477022 @default.
• W2149086311 cites W1480021174 @default.
• W2149086311 cites W1824064536 @default.
• W2149086311 cites W1984249600 @default.
• W2149086311 cites W2007544324 @default.
• W2149086311 cites W2093998596 @default.
• W2149086311 cites W2107587942 @default.
• W2149086311 cites W2109004475 @default.
• W2149086311 cites W2125385820 @default.
• W2149086311 cites W2169635257 @default.
• W2149086311 cites W2223214578 @default.
• W2149086311 cites W2409604523 @default.
• W2149086311 cites W2411658321 @default.
• W2149086311 cites W2418930597 @default.
• W2149086311 cites W2419333885 @default.
• W2149086311 cites W2421804143 @default.
• W2149086311 doi "https://doi.org/10.1016/s1010-7940(01)00719-9" @default.
• W2149086311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11423293" @default.
• W2149086311 hasPublicationYear "2001" @default.
• W2149086311 type Work @default.
• W2149086311 sameAs 2149086311 @default.
• W2149086311 citedByCount "11" @default.
• W2149086311 countsByYear W21490863112023 @default.
• W2149086311 crossrefType "journal-article" @default.
• W2149086311 hasAuthorship W2149086311A5018736252 @default.
• W2149086311 hasAuthorship W2149086311A5021403561 @default.
• W2149086311 hasAuthorship W2149086311A5024727740 @default.
• W2149086311 hasAuthorship W2149086311A5029942292 @default.
• W2149086311 hasAuthorship W2149086311A5072252590 @default.
• W2149086311 hasAuthorship W2149086311A5073446648 @default.
• W2149086311 hasBestOaLocation W21490863111 @default.
• W2149086311 hasConcept C126322002 @default.
• W2149086311 hasConcept C164705383 @default.
• W2149086311 hasConcept C204232928 @default.
• W2149086311 hasConcept C2778849806 @default.
• W2149086311 hasConcept C2779868719 @default.
• W2149086311 hasConcept C2780346441 @default.
• W2149086311 hasConcept C2911091166 @default.
• W2149086311 hasConcept C39078644 @default.
• W2149086311 hasConcept C57900726 @default.
• W2149086311 hasConcept C71924100 @default.
• W2149086311 hasConcept C84393581 @default.
• W2149086311 hasConceptScore W2149086311C126322002 @default.
• W2149086311 hasConceptScore W2149086311C164705383 @default.
• W2149086311 hasConceptScore W2149086311C204232928 @default.
• W2149086311 hasConceptScore W2149086311C2778849806 @default.
• W2149086311 hasConceptScore W2149086311C2779868719 @default.
• W2149086311 hasConceptScore W2149086311C2780346441 @default.
• W2149086311 hasConceptScore W2149086311C2911091166 @default.
• W2149086311 hasConceptScore W2149086311C39078644 @default.
• W2149086311 hasConceptScore W2149086311C57900726 @default.
• W2149086311 hasConceptScore W2149086311C71924100 @default.
• W2149086311 hasConceptScore W2149086311C84393581 @default.
• W2149086311 hasIssue "1" @default.
• W2149086311 hasLocation W21490863111 @default.
• W2149086311 hasLocation W21490863112 @default.
• W2149086311 hasOpenAccess W2149086311 @default.
• W2149086311 hasPrimaryLocation W21490863111 @default.
• W2149086311 hasRelatedWork W1969749502 @default.
• W2149086311 hasRelatedWork W1975411218 @default.
• W2149086311 hasRelatedWork W1977430293 @default.
• W2149086311 hasRelatedWork W2014208688 @default.
• W2149086311 hasRelatedWork W2042348197 @default.
• W2149086311 hasRelatedWork W2079532331 @default.
• W2149086311 hasRelatedWork W2354333070 @default.
• W2149086311 hasRelatedWork W2406609674 @default.
• W2149086311 hasRelatedWork W2407012488 @default.
• W2149086311 hasRelatedWork W3143779517 @default.
• W2149086311 hasVolume "20" @default.
• W2149086311 isParatext "false" @default.
• W2149086311 isRetracted "false" @default.
• W2149086311 magId "2149086311" @default.
• W2149086311 workType "article" @default.