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- W2149087378 abstract "Upon invasion into erythrocytes, the malaria parasite Plasmodium falciparum must refurbish the host cell. The objective of this study was to elucidate the location and function of MAHRP2 in these processes. Using immunofluorescence and immunoelectron microscopy we showed that the membrane-associated histidine-rich protein-2 (MAHRP2) is exported during this process to novel cylindrical structures in the erythrocyte cytoplasm. We hypothesize that these structures tether organelles known as Maurer's clefts to the erythrocyte skeleton. Live cell imaging of parasite transfectants expressing MAHRP2–GFP revealed both mobile and fixed populations of the tether-like structures. Differential centrifugation allowed the enrichment of these novel structures. MAHRP2 possesses neither a signal peptide nor a PEXEL motif, and sequences required for export were determined using transfectants expressing truncated MAHRP2 fragments. The first 15 amino acids and the histidine-rich N-terminal region are necessary for correct trafficking of MAHRP2 together with a predicted hydrophobic region. Solubilization studies showed that MAHRP2 is membrane associated but not membrane spanning. Several attempts to delete the mahrp2 gene failed, indicating that the protein is essential for parasite survival." @default.
- W2149087378 created "2016-06-24" @default.
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- W2149087378 date "2010-08-25" @default.
- W2149087378 modified "2023-10-16" @default.
- W2149087378 title "MAHRP2, an exported protein of Plasmodium falciparum, is an essential component of Maurer's cleft tethers" @default.
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- W2149087378 doi "https://doi.org/10.1111/j.1365-2958.2010.07278.x" @default.
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