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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149089744> ?p ?o ?g. }

• W2149089744 endingPage "1142" @default.
• W2149089744 startingPage "1133" @default.
• W2149089744 abstract "Nuclear factor kappa B (NF-kappa B) is an important transcription factor in inflammation that has obtained a great interest as a drug target for the treatment of various allergic conditions. In this study, we show that the histamine H(1) receptor, which is also an important player in allergic and inflammatory conditions, activates NF-kappa B in both a constitutive and agonist-dependent manner. Moreover, the observed constitutive NF-kappa B activation is inhibited by various H(1)-receptor antagonists, suggesting that inverse agonism may account, at least in part, for their ascribed antiallergic properties. Investigation of the H(1) receptor-mediated NF-kappa B activation in transfected COS-7 cells indicates that the level of the observed constitutive activity of the H(1) receptor can be modulated by the expression levels of either G alpha-proteins or G beta gamma-heterodimers. Members of the G alpha(q/11)-family of G alpha-proteins are most effective in increasing H(1) constitutive activity. Also, coexpression of G beta(2) in combination with either G gamma(1) or G gamma(2) results in an increased constitutive activity of the H(1) receptor, whereas scavenging of G beta gamma-subunits by coexpression of G alpha(t) completely neutralizes the constitutive, but not the agonist-induced, NF-kappa B activity. Our data suggest that both G alpha(q/11)- and G beta gamma-subunits play a role in the agonist-induced, H(1) receptor-mediated NF-kappa B activation, but that constitutive NF-kappa B activation by the H(1) receptor is primarily mediated through G beta gamma-subunits." @default.
• W2149089744 created "2016-06-24" @default.
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• W2149089744 date "2001-11-01" @default.
• W2149089744 modified "2023-10-18" @default.
• W2149089744 title "Histamine H₁-Receptor Activation of Nuclear Factor-κB: Roles for Gβγ- and Gα_q/11-Subunits in Constitutive and Agonist-Mediated Signaling" @default.
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• W2149089744 doi "https://doi.org/10.1124/mol.60.5.1133" @default.
• W2149089744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11641442" @default.
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