FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149093067> ?p ?o ?g. }

• W2149093067 abstract "Avascular necrosis of bone is a frequent and severe complication of sickle cell disease and its treatment is not standardised. This is an update of a previously published Cochrane Review.To determine the impact of any surgical procedure compared with other surgical interventions or non-surgical procedures, on avascular necrosis of bone in people with sickle cell disease in terms of efficacy and safety.We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Haemoglobinopathies Trials Register, comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings. Additional trials were sought from the reference lists of papers identified by the search strategy.Date of the most recent search of the Group's Haemoglobinopathies Trials Register: 27 May 2016.Randomized clinical trials comparing specific therapies for avascular necrosis of bone in people with sickle cell disease.Each author independently extracted data and assessed trial quality. Since only one trial was identified, meta-analysis was not possible.One trial (46 participants) was eligible for inclusion. After randomization eight participants were withdrawn, mainly because they declined to participate in the trial. Data were analysed for 38 participants at the end of the trial. After a mean follow up of three years, hip core decompression and physical therapy did not show clinical improvement when compared with physical therapy alone using the score from the original trial (an improvement of 18.1 points for those treated with intervention therapy versus an improvement of 15.7 points with control therapy). There was no significant statistical difference between groups regarding major complications (hip pain, risk ratio 0.95 (95% confidence interval 0.56 to 1.60; vaso-occlusive crises, risk ratio 1.14 (95% confidence interval 0.72 to 1.80; very low quality of evidence); and acute chest syndrome, risk ratio 1.06 (95% confidence interval 0.44 to 2.56; very low quality of evidence)). This trial did not report results on mortality or quality of life.We found no evidence that adding hip core decompression to physical therapy achieves clinical improvement in people with sickle cell disease with avascular necrosis of bone compared to physical therapy alone. However, we highlight that our conclusion is based on one trial with high attrition rates. Further randomized controlled trials are necessary to evaluate the role of hip-core depression for this clinical condition. Endpoints should focus on participants' subjective experience (e.g. quality of life and pain) as well as more objective 'time-to-event' measures (e.g. mortality, survival, hip longevity). The availability of participants to allow adequate trial power will be a key consideration for endpoint choice." @default.
• W2149093067 created "2016-06-24" @default.
• W2149093067 creator A5044974328 @default.
• W2149093067 creator A5054278670 @default.
• W2149093067 creator A5055841616 @default.
• W2149093067 date "2016-08-09" @default.
• W2149093067 modified "2023-09-27" @default.
• W2149093067 title "Treatment for avascular necrosis of bone in people with sickle cell disease" @default.
• W2149093067 cites W1557287294 @default.
• W2149093067 cites W1598602811 @default.
• W2149093067 cites W172121496 @default.
• W2149093067 cites W1893278008 @default.
• W2149093067 cites W1970294445 @default.
• W2149093067 cites W1972308318 @default.
• W2149093067 cites W1974575086 @default.
• W2149093067 cites W1988581070 @default.
• W2149093067 cites W1990885714 @default.
• W2149093067 cites W2005267672 @default.
• W2149093067 cites W2009612604 @default.
• W2149093067 cites W2012111878 @default.
• W2149093067 cites W2015766484 @default.
• W2149093067 cites W2020112929 @default.
• W2149093067 cites W2027816595 @default.
• W2149093067 cites W2033564982 @default.
• W2149093067 cites W2033975683 @default.
• W2149093067 cites W2035346142 @default.
• W2149093067 cites W2042575456 @default.
• W2149093067 cites W2043008955 @default.
• W2149093067 cites W2048659740 @default.
• W2149093067 cites W2053420662 @default.
• W2149093067 cites W2068376536 @default.
• W2149093067 cites W2073204534 @default.
• W2149093067 cites W2115450562 @default.
• W2149093067 cites W2123729651 @default.
• W2149093067 cites W2125435699 @default.
• W2149093067 cites W2145006345 @default.
• W2149093067 cites W2150550839 @default.
• W2149093067 cites W2169928924 @default.
• W2149093067 cites W2326476344 @default.
• W2149093067 cites W2914437448 @default.
• W2149093067 cites W42126750 @default.
• W2149093067 cites W4242828431 @default.
• W2149093067 cites W4246308263 @default.
• W2149093067 cites W4249449362 @default.
• W2149093067 doi "https://doi.org/10.1002/14651858.cd004344.pub6" @default.
• W2149093067 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6894369" @default.
• W2149093067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31803937" @default.
• W2149093067 hasPublicationYear "2016" @default.
• W2149093067 type Work @default.
• W2149093067 sameAs 2149093067 @default.
• W2149093067 citedByCount "21" @default.
• W2149093067 countsByYear W21490930672014 @default.
• W2149093067 countsByYear W21490930672015 @default.
• W2149093067 countsByYear W21490930672016 @default.
• W2149093067 countsByYear W21490930672017 @default.
• W2149093067 countsByYear W21490930672018 @default.
• W2149093067 countsByYear W21490930672019 @default.
• W2149093067 countsByYear W21490930672020 @default.
• W2149093067 countsByYear W21490930672021 @default.
• W2149093067 countsByYear W21490930672022 @default.
• W2149093067 countsByYear W21490930672023 @default.
• W2149093067 crossrefType "journal-article" @default.
• W2149093067 hasAuthorship W2149093067A5044974328 @default.
• W2149093067 hasAuthorship W2149093067A5054278670 @default.
• W2149093067 hasAuthorship W2149093067A5055841616 @default.
• W2149093067 hasConcept C126322002 @default.
• W2149093067 hasConcept C141071460 @default.
• W2149093067 hasConcept C168563851 @default.
• W2149093067 hasConcept C17744445 @default.
• W2149093067 hasConcept C1862650 @default.
• W2149093067 hasConcept C187212893 @default.
• W2149093067 hasConcept C189708586 @default.
• W2149093067 hasConcept C199539241 @default.
• W2149093067 hasConcept C204243189 @default.
• W2149093067 hasConcept C2777560053 @default.
• W2149093067 hasConcept C2779100257 @default.
• W2149093067 hasConcept C2779134260 @default.
• W2149093067 hasConcept C2779473830 @default.
• W2149093067 hasConcept C535046627 @default.
• W2149093067 hasConcept C71924100 @default.
• W2149093067 hasConcept C95190672 @default.
• W2149093067 hasConceptScore W2149093067C126322002 @default.
• W2149093067 hasConceptScore W2149093067C141071460 @default.
• W2149093067 hasConceptScore W2149093067C168563851 @default.
• W2149093067 hasConceptScore W2149093067C17744445 @default.
• W2149093067 hasConceptScore W2149093067C1862650 @default.
• W2149093067 hasConceptScore W2149093067C187212893 @default.
• W2149093067 hasConceptScore W2149093067C189708586 @default.
• W2149093067 hasConceptScore W2149093067C199539241 @default.
• W2149093067 hasConceptScore W2149093067C204243189 @default.
• W2149093067 hasConceptScore W2149093067C2777560053 @default.
• W2149093067 hasConceptScore W2149093067C2779100257 @default.
• W2149093067 hasConceptScore W2149093067C2779134260 @default.
• W2149093067 hasConceptScore W2149093067C2779473830 @default.
• W2149093067 hasConceptScore W2149093067C535046627 @default.
• W2149093067 hasConceptScore W2149093067C71924100 @default.
• W2149093067 hasConceptScore W2149093067C95190672 @default.
• W2149093067 hasLocation W21490930671 @default.
• W2149093067 hasLocation W21490930672 @default.
• W2149093067 hasOpenAccess W2149093067 @default.

• next