FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149098906> ?p ?o ?g. }

• W2149098906 endingPage "000" @default.
• W2149098906 startingPage "100127142343070" @default.
• W2149098906 abstract "Background. Coinfection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) has emerged as a major cause of morbidity and mortality due to liver disease. Interferon-based therapy response rates have been disappointingly low. Baseline HCV complexity and the relationship between complexity and viral kinetic parameters has not been well described in HCV/HIV-coinfected subjects. Methods. A subset of patients enrolled in the AIDS Clinical Trials Group 5071 trial underwent sampling to evaluate viral kinetics and changes in HCV complexity. Early kinetic parameters, baseline complexity, and treatment outcomes—including rapid viral response (RVR), early viral response (EVR), and sustained viral response (SVR)— were evaluated. HCV-monoinfected subjects were matched to HCV/HIV-coinfected subjects. Results. Baseline complexity was determined in 108 HCV/HIV-coinfected subjects and in 13 HCV-monoinfected control subjects. Quasispecies complexity was a mean of 2.24 bands for HCV/HIV-coinfected subjects and a mean of 1.90 bands for HCV-monoinfected subjects (P=.14). Lower baseline complexity was associated with EVR (P=.04) and approached statistical significance for SVR. In patients who underwent viral kinetic modeling, a decrease in complexity was associated with RVR (P=.03) and was independent of the correlation between first-phase viral decline efficiency and RVR. Conclusion. Baseline HCV complexity is an independent predictor of EVR in HCV/HIV-coinfected subjects. A decrease in complexity occurs by 4 weeks after the initiation of interferon-based therapy and is associated with RVR. These findings may enhance the predictive modeling of treatment outcome in HCV/HIV-coinfected patients." @default.
• W2149098906 created "2016-06-24" @default.
• W2149098906 creator A5000964738 @default.
• W2149098906 creator A5020069661 @default.
• W2149098906 creator A5035176861 @default.
• W2149098906 creator A5049643664 @default.
• W2149098906 creator A5055495178 @default.
• W2149098906 creator A5067068499 @default.
• W2149098906 creator A5071197238 @default.
• W2149098906 creator A5084104464 @default.
• W2149098906 date "2010-01-27" @default.
• W2149098906 modified "2023-09-23" @default.
• W2149098906 title "Hepatitis C Virus (HCV) Quasispecies Complexity and Selection in HCV/HIV‐Coinfected Subjects Treated with Interferon‐Based Regimens" @default.
• W2149098906 cites W1967891186 @default.
• W2149098906 cites W1971818550 @default.
• W2149098906 cites W1978339383 @default.
• W2149098906 cites W1980413518 @default.
• W2149098906 cites W1990642730 @default.
• W2149098906 cites W1993484328 @default.
• W2149098906 cites W1996434966 @default.
• W2149098906 cites W2002099217 @default.
• W2149098906 cites W2029160132 @default.
• W2149098906 cites W2039071051 @default.
• W2149098906 cites W2042272201 @default.
• W2149098906 cites W2044960822 @default.
• W2149098906 cites W2050776853 @default.
• W2149098906 cites W2065534484 @default.
• W2149098906 cites W2099847630 @default.
• W2149098906 cites W2103529803 @default.
• W2149098906 cites W2104638890 @default.
• W2149098906 cites W2120355950 @default.
• W2149098906 cites W2120479348 @default.
• W2149098906 cites W2121595515 @default.
• W2149098906 cites W2124528668 @default.
• W2149098906 cites W2133954858 @default.
• W2149098906 cites W2152664737 @default.
• W2149098906 cites W83931366 @default.
• W2149098906 doi "https://doi.org/10.1086/650490" @default.
• W2149098906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2827649" @default.
• W2149098906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20105080" @default.
• W2149098906 hasPublicationYear "2010" @default.
• W2149098906 type Work @default.
• W2149098906 sameAs 2149098906 @default.
• W2149098906 citedByCount "7" @default.
• W2149098906 countsByYear W21490989062013 @default.
• W2149098906 countsByYear W21490989062015 @default.
• W2149098906 countsByYear W21490989062016 @default.
• W2149098906 countsByYear W21490989062019 @default.
• W2149098906 countsByYear W21490989062020 @default.
• W2149098906 countsByYear W21490989062022 @default.
• W2149098906 crossrefType "journal-article" @default.
• W2149098906 hasAuthorship W2149098906A5000964738 @default.
• W2149098906 hasAuthorship W2149098906A5020069661 @default.
• W2149098906 hasAuthorship W2149098906A5035176861 @default.
• W2149098906 hasAuthorship W2149098906A5049643664 @default.
• W2149098906 hasAuthorship W2149098906A5055495178 @default.
• W2149098906 hasAuthorship W2149098906A5067068499 @default.
• W2149098906 hasAuthorship W2149098906A5071197238 @default.
• W2149098906 hasAuthorship W2149098906A5084104464 @default.
• W2149098906 hasBestOaLocation W21490989061 @default.
• W2149098906 hasConcept C126322002 @default.
• W2149098906 hasConcept C142462285 @default.
• W2149098906 hasConcept C14500911 @default.
• W2149098906 hasConcept C159047783 @default.
• W2149098906 hasConcept C203014093 @default.
• W2149098906 hasConcept C2522874641 @default.
• W2149098906 hasConcept C2776408679 @default.
• W2149098906 hasConcept C2776455275 @default.
• W2149098906 hasConcept C2777813720 @default.
• W2149098906 hasConcept C2781463415 @default.
• W2149098906 hasConcept C71924100 @default.
• W2149098906 hasConceptScore W2149098906C126322002 @default.
• W2149098906 hasConceptScore W2149098906C142462285 @default.
• W2149098906 hasConceptScore W2149098906C14500911 @default.
• W2149098906 hasConceptScore W2149098906C159047783 @default.
• W2149098906 hasConceptScore W2149098906C203014093 @default.
• W2149098906 hasConceptScore W2149098906C2522874641 @default.
• W2149098906 hasConceptScore W2149098906C2776408679 @default.
• W2149098906 hasConceptScore W2149098906C2776455275 @default.
• W2149098906 hasConceptScore W2149098906C2777813720 @default.
• W2149098906 hasConceptScore W2149098906C2781463415 @default.
• W2149098906 hasConceptScore W2149098906C71924100 @default.
• W2149098906 hasLocation W21490989061 @default.
• W2149098906 hasLocation W21490989062 @default.
• W2149098906 hasLocation W21490989063 @default.
• W2149098906 hasLocation W21490989064 @default.
• W2149098906 hasOpenAccess W2149098906 @default.
• W2149098906 hasPrimaryLocation W21490989061 @default.
• W2149098906 hasRelatedWork W1981812015 @default.
• W2149098906 hasRelatedWork W2039071051 @default.
• W2149098906 hasRelatedWork W2083764408 @default.
• W2149098906 hasRelatedWork W2087328304 @default.
• W2149098906 hasRelatedWork W2105066145 @default.
• W2149098906 hasRelatedWork W2108669201 @default.
• W2149098906 hasRelatedWork W2113729156 @default.
• W2149098906 hasRelatedWork W2319781295 @default.
• W2149098906 hasRelatedWork W2553044210 @default.
• W2149098906 hasRelatedWork W4231704069 @default.

• next