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- W2149099892 abstract "Double-strand break (DSB) repair pathways catalyze the rejoining of broken chromosomes and the integration of transforming DNAs. These processes have been well characterized in bacteria, fungi, and animals. Plants are generally thought primarily to utilize a non-homologous end joining (NHEJ) pathway to repair DSBs and integrate transgenes, as transforming DNAs with large tracts of homology to the chromosome are integrated at random. In order to test the hypothesis that NHEJ is an important pathway for the repair of DSBs in plants, we isolated T-DNA insertion mutations in the Arabidopsis homologs of the Ku80 and DNA ligase IV genes, required for the initiation and completion, respectively, of NHEJ. Both mutants were hypersensitive to the cytostatic effects of gamma radiation, suggesting that NHEJ is indeed a critical pathway for the repair of DSBs. T-DNA insertion rates were also decreased in the mutants, indicating that Ku80 and DNA ligase IV play an important role in either the mechanism or the regulation of T-DNA integration in Arabidopsis." @default.
- W2149099892 created "2016-06-24" @default.
- W2149099892 creator A5000425451 @default.
- W2149099892 creator A5088716539 @default.
- W2149099892 date "2003-05-01" @default.
- W2149099892 modified "2023-10-17" @default.
- W2149099892 title "Ku80- and DNA ligase IV-deficient plants are sensitive to ionizing radiation and defective in T-DNA integration" @default.
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- W2149099892 doi "https://doi.org/10.1046/j.1365-313x.2003.01738.x" @default.
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