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- W2149100735 abstract "Since the discovery that the concentration of circulating tumor cells (CTCs) in blood is a strong predictor of survival rate in metastatic breast cancer (1), there has been great enthusiasm for the potential of these cells as a marker for cancer progression. The technical challenge is to isolate these rare cells (1–100 cells/mL) from whole blood with sufficient sensitivity and specificity, while maintaining cell viability for postcapture analysis. The most widespread methods of CTC isolation are based on immunocapture of antigens highly expressed on CTCs. Epithelial cell adhesion molecule and prostate-specific membrane antigen are the most extensively characterized antigens used for immunologic detection of carcinomas (2). These antigens are often used in conjunction with cytokeratin, an epithelial marker, to discriminate CTCs from leukocytes.Immunocapture methods can be divided into bead-based approaches and microfluidic approaches. In bead-based approaches, antibody-coated magnetic nanoparticles bind to CTCs in a suspension of blood cells, and the CTCs are then separated with a magnetic field. This is the basis for Veridex's CellSearch®, the only CTC-enumeration assay cleared by the US Food and Drug Administration (3). The disadvantage of this assay is that it requires multiple processing steps—centrifugation, dilution, capture, separation—and leaves the captured cells nonviable. In microfluidic approaches, whole blood is perfused through channels within which cells collide with antibodies immobilized on the channel walls or obstacles within the …" @default.
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- W2149100735 date "2012-05-01" @default.
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- W2149100735 title "Catch Me If You Can: Isolating Circulating Tumor Cells from Flowing Blood" @default.
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- W2149100735 doi "https://doi.org/10.1373/clinchem.2012.182600" @default.
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