Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149102992> ?p ?o ?g. }
- W2149102992 endingPage "161" @default.
- W2149102992 startingPage "156" @default.
- W2149102992 abstract "The enzyme-directed synthesis is an emerging fragment-based lead discovery approach in which the biological target is able to assemble its own multidentate ligands from a pool of building blocks. Here, we report for the first time the use of the human acetylcholinesterase (AChE) as an enzyme for the design and synthesis of new potent heterodimeric huprine-based inhibitors. Both the specific click chemistry site within the protein and the regioselectivity of the Huisgen cycloaddition observed suggest promising alternatives in the design of efficient mono- and dimeric ligands of AChE. Finally, a detailed computational modelling of the click reaction was conducted to further understand the origin of this TGS selectivity." @default.
- W2149102992 created "2016-06-24" @default.
- W2149102992 creator A5002341367 @default.
- W2149102992 creator A5011412856 @default.
- W2149102992 creator A5014291543 @default.
- W2149102992 creator A5017532924 @default.
- W2149102992 creator A5035512825 @default.
- W2149102992 creator A5037698489 @default.
- W2149102992 creator A5038664509 @default.
- W2149102992 creator A5051490485 @default.
- W2149102992 creator A5073198689 @default.
- W2149102992 creator A5075440909 @default.
- W2149102992 creator A5076929198 @default.
- W2149102992 creator A5080040545 @default.
- W2149102992 date "2014-01-01" @default.
- W2149102992 modified "2023-10-17" @default.
- W2149102992 title "Reaction site-driven regioselective synthesis of AChE inhibitors" @default.
- W2149102992 cites W1963558565 @default.
- W2149102992 cites W1964545163 @default.
- W2149102992 cites W1964662263 @default.
- W2149102992 cites W1965780953 @default.
- W2149102992 cites W1971170829 @default.
- W2149102992 cites W1978876482 @default.
- W2149102992 cites W1981471145 @default.
- W2149102992 cites W1981775239 @default.
- W2149102992 cites W1982204137 @default.
- W2149102992 cites W1986660597 @default.
- W2149102992 cites W1996024594 @default.
- W2149102992 cites W2001580341 @default.
- W2149102992 cites W2008742048 @default.
- W2149102992 cites W2009221410 @default.
- W2149102992 cites W2010688465 @default.
- W2149102992 cites W2011671086 @default.
- W2149102992 cites W2025973903 @default.
- W2149102992 cites W2029954340 @default.
- W2149102992 cites W2036112807 @default.
- W2149102992 cites W2041887070 @default.
- W2149102992 cites W2047420624 @default.
- W2149102992 cites W2061541199 @default.
- W2149102992 cites W2062699336 @default.
- W2149102992 cites W2066457093 @default.
- W2149102992 cites W2087765372 @default.
- W2149102992 cites W2089439375 @default.
- W2149102992 cites W2093175298 @default.
- W2149102992 cites W2095064953 @default.
- W2149102992 cites W2104182950 @default.
- W2149102992 cites W2146910635 @default.
- W2149102992 cites W2150118450 @default.
- W2149102992 cites W2150804079 @default.
- W2149102992 cites W2152147380 @default.
- W2149102992 cites W4249984318 @default.
- W2149102992 cites W2003258099 @default.
- W2149102992 doi "https://doi.org/10.1039/c3ob42109k" @default.
- W2149102992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24216754" @default.
- W2149102992 hasPublicationYear "2014" @default.
- W2149102992 type Work @default.
- W2149102992 sameAs 2149102992 @default.
- W2149102992 citedByCount "22" @default.
- W2149102992 countsByYear W21491029922014 @default.
- W2149102992 countsByYear W21491029922015 @default.
- W2149102992 countsByYear W21491029922016 @default.
- W2149102992 countsByYear W21491029922017 @default.
- W2149102992 countsByYear W21491029922018 @default.
- W2149102992 countsByYear W21491029922019 @default.
- W2149102992 countsByYear W21491029922020 @default.
- W2149102992 countsByYear W21491029922021 @default.
- W2149102992 countsByYear W21491029922022 @default.
- W2149102992 countsByYear W21491029922023 @default.
- W2149102992 crossrefType "journal-article" @default.
- W2149102992 hasAuthorship W2149102992A5002341367 @default.
- W2149102992 hasAuthorship W2149102992A5011412856 @default.
- W2149102992 hasAuthorship W2149102992A5014291543 @default.
- W2149102992 hasAuthorship W2149102992A5017532924 @default.
- W2149102992 hasAuthorship W2149102992A5035512825 @default.
- W2149102992 hasAuthorship W2149102992A5037698489 @default.
- W2149102992 hasAuthorship W2149102992A5038664509 @default.
- W2149102992 hasAuthorship W2149102992A5051490485 @default.
- W2149102992 hasAuthorship W2149102992A5073198689 @default.
- W2149102992 hasAuthorship W2149102992A5075440909 @default.
- W2149102992 hasAuthorship W2149102992A5076929198 @default.
- W2149102992 hasAuthorship W2149102992A5080040545 @default.
- W2149102992 hasConcept C118792377 @default.
- W2149102992 hasConcept C161790260 @default.
- W2149102992 hasConcept C181199279 @default.
- W2149102992 hasConcept C185592680 @default.
- W2149102992 hasConcept C21951064 @default.
- W2149102992 hasConcept C2778816929 @default.
- W2149102992 hasConcept C2779664164 @default.
- W2149102992 hasConcept C41183919 @default.
- W2149102992 hasConcept C55493867 @default.
- W2149102992 hasConcept C59759590 @default.
- W2149102992 hasConcept C69610077 @default.
- W2149102992 hasConcept C71240020 @default.
- W2149102992 hasConceptScore W2149102992C118792377 @default.
- W2149102992 hasConceptScore W2149102992C161790260 @default.
- W2149102992 hasConceptScore W2149102992C181199279 @default.
- W2149102992 hasConceptScore W2149102992C185592680 @default.
- W2149102992 hasConceptScore W2149102992C21951064 @default.