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- W2149104401 abstract "Of the various complications in liver cirrhosis including intestinal bleeding, ascites and hepatocellular carcinoma, the rapidly progressive form of kidney dysfunction in cirrhosis, i.e. hepatorenal syndrome type 1, still carries the worst prognosis. In the early 1990s, median survival of these patients was reported to be as short as two weeks [1] and some more recent papers indicate that, in terms of prognosis, there has not been much progress since [2]. However, during the past two decades, new treatment concepts based on an improved pathophysiological understanding of the mechanisms ultimately leading to hepatorenal syndrome (HRS) have been introduced, and—very recently—a first randomized, controlled trial evaluating one of these concepts (i.e. vasoconstrictor treatment with the vasopressin analogue terlipressin) has been published in abstract form [3]. Despite successful drug treatment approaches, to date, the only definitive treatment of HRS type 1 is liver transplantation or even combined liver/kidney transplantation in some patients. This article aims at reviewing the currently available data on diagnosis, prognosis and treatment of hepatorenal syndrome." @default.
- W2149104401 created "2016-06-24" @default.
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- W2149104401 date "2007-09-01" @default.
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- W2149104401 title "Hepatorenal syndrome: current diagnostic and therapeutic concepts" @default.
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- W2149104401 doi "https://doi.org/10.1093/ndt/gfm656" @default.
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