FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149117400> ?p ?o ?g. }

• W2149117400 endingPage "967" @default.
• W2149117400 startingPage "958" @default.
• W2149117400 abstract "Estrogen receptor-alpha (ESR1) is highly expressed in the efferent ductules of all species studied as well as in the epididymal epithelium in mice and other select species. Male mice lacking ESR1 (Esr1KO) are infertile, but transplantation studies demonstrated that Esr1KO germ cells are capable of fertilization when placed in a wild-type reproductive tract. These results suggest that extratesticular regions, such as the efferent ductules and epididymis, are the major source of pathological changes in Esr1KO males. Previous studies have shown alterations in ion and fluid transporters in the efferent duct and epididymal epithelia of Esr1KO males, leading to misregulation of luminal fluid pH. To determine the effect of an altered epididymal milieu on Esr1KO sperm, we assayed sperm morphology in the different regions of the epididymis. Sperm recovered from the epididymis exhibited abnormal flagellar coiling and increased incidence of spontaneous acrosome reactions, both of which are consistent with exposure to abnormal epididymal fluid. Analysis of the epididymal fluid revealed that the osmolality of the Esr1KO fluid was reduced relative to wild type, consistent with prior reports of inappropriate fluid absorption from the efferent ductules. This, along with the finding that morphological defects increased with transit through the epididymal duct, suggests that the anomalies in sperm are a consequence of the abnormal luminal environment. Consistent with this, incubating Esr1KO sperm in a more wild-type-like osmotic environment significantly rescued the abnormal flagellar coiling. This work demonstrates that Esr1KO mice exhibit an abnormal fluid environment in the lumen of the efferent ducts and epididymis, precluding normal sperm maturation and instead resulting in progressive deterioration of sperm that contributes to infertility." @default.
• W2149117400 created "2016-06-24" @default.
• W2149117400 creator A5009194998 @default.
• W2149117400 creator A5029959891 @default.
• W2149117400 creator A5052054514 @default.
• W2149117400 creator A5081664492 @default.
• W2149117400 creator A5085761422 @default.
• W2149117400 date "2010-05-01" @default.
• W2149117400 modified "2023-10-05" @default.
• W2149117400 title "Epididymal Hypo-Osmolality Induces Abnormal Sperm Morphology and Function in the Estrogen Receptor Alpha Knockout Mouse1" @default.
• W2149117400 cites W143470994 @default.
• W2149117400 cites W1547137876 @default.
• W2149117400 cites W1963817603 @default.
• W2149117400 cites W1964721684 @default.
• W2149117400 cites W1968378128 @default.
• W2149117400 cites W1971824281 @default.
• W2149117400 cites W1978559815 @default.
• W2149117400 cites W1986158862 @default.
• W2149117400 cites W1988506290 @default.
• W2149117400 cites W1990717330 @default.
• W2149117400 cites W1996447761 @default.
• W2149117400 cites W1999099572 @default.
• W2149117400 cites W2003769012 @default.
• W2149117400 cites W2004506740 @default.
• W2149117400 cites W2007370645 @default.
• W2149117400 cites W2013977341 @default.
• W2149117400 cites W2023551633 @default.
• W2149117400 cites W2027289933 @default.
• W2149117400 cites W2028903483 @default.
• W2149117400 cites W2030987021 @default.
• W2149117400 cites W2040384117 @default.
• W2149117400 cites W2042659536 @default.
• W2149117400 cites W2044211850 @default.
• W2149117400 cites W2044371682 @default.
• W2149117400 cites W2045573046 @default.
• W2149117400 cites W2045643557 @default.
• W2149117400 cites W2047615096 @default.
• W2149117400 cites W2048076953 @default.
• W2149117400 cites W2052413474 @default.
• W2149117400 cites W2062979244 @default.
• W2149117400 cites W2070509582 @default.
• W2149117400 cites W2072958920 @default.
• W2149117400 cites W2077251269 @default.
• W2149117400 cites W2078468363 @default.
• W2149117400 cites W2082149911 @default.
• W2149117400 cites W2099889901 @default.
• W2149117400 cites W2100898329 @default.
• W2149117400 cites W2110267269 @default.
• W2149117400 cites W2117660458 @default.
• W2149117400 cites W2120653485 @default.
• W2149117400 cites W2127939948 @default.
• W2149117400 cites W2136149736 @default.
• W2149117400 cites W2146530668 @default.
• W2149117400 cites W2149377988 @default.
• W2149117400 cites W2152038391 @default.
• W2149117400 cites W2152683567 @default.
• W2149117400 cites W2153605568 @default.
• W2149117400 cites W2154045445 @default.
• W2149117400 cites W2154389090 @default.
• W2149117400 cites W2164870672 @default.
• W2149117400 cites W2167174312 @default.
• W2149117400 cites W2167481266 @default.
• W2149117400 cites W2169708348 @default.
• W2149117400 doi "https://doi.org/10.1095/biolreprod.109.080366" @default.
• W2149117400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2857636" @default.
• W2149117400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20130266" @default.
• W2149117400 hasPublicationYear "2010" @default.
• W2149117400 type Work @default.
• W2149117400 sameAs 2149117400 @default.
• W2149117400 citedByCount "73" @default.
• W2149117400 countsByYear W21491174002012 @default.
• W2149117400 countsByYear W21491174002014 @default.
• W2149117400 countsByYear W21491174002015 @default.
• W2149117400 countsByYear W21491174002016 @default.
• W2149117400 countsByYear W21491174002017 @default.
• W2149117400 countsByYear W21491174002018 @default.
• W2149117400 countsByYear W21491174002019 @default.
• W2149117400 countsByYear W21491174002020 @default.
• W2149117400 countsByYear W21491174002021 @default.
• W2149117400 countsByYear W21491174002022 @default.
• W2149117400 crossrefType "journal-article" @default.
• W2149117400 hasAuthorship W2149117400A5009194998 @default.
• W2149117400 hasAuthorship W2149117400A5029959891 @default.
• W2149117400 hasAuthorship W2149117400A5052054514 @default.
• W2149117400 hasAuthorship W2149117400A5081664492 @default.
• W2149117400 hasAuthorship W2149117400A5085761422 @default.
• W2149117400 hasBestOaLocation W21491174001 @default.
• W2149117400 hasConcept C105702510 @default.
• W2149117400 hasConcept C126322002 @default.
• W2149117400 hasConcept C134018914 @default.
• W2149117400 hasConcept C16685009 @default.
• W2149117400 hasConcept C2776512019 @default.
• W2149117400 hasConcept C2778395058 @default.
• W2149117400 hasConcept C2778724953 @default.
• W2149117400 hasConcept C2779263132 @default.
• W2149117400 hasConcept C2781087480 @default.
• W2149117400 hasConcept C2781254305 @default.
• W2149117400 hasConcept C59822182 @default.

• next