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- W2149118112 abstract "Drosophila responds to Gram-negative infections by mounting an immune response that depends on components of the IMD pathway. We recently showed that imd encodes a protein with a death domain with high similarity to that of mammalian RIP. Using a two-hybrid screen in yeast, we have isolated the death protein dFADD as a molecule that associates with IMD. Our data show that loss of dFADD function renders flies highly susceptible to Gram-negative infections without affecting resistance to Gram-positive bacteria. By genetic analysis we show that dFADD acts downstream of IMD in the pathway that controls inducibility of the antibacterial peptide genes." @default.
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- W2149118112 date "2002-11-01" @default.
- W2149118112 modified "2023-10-18" @default.
- W2149118112 title "The Drosophila Immune Defense against Gram-Negative Infection Requires the Death Protein dFADD" @default.
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- W2149118112 doi "https://doi.org/10.1016/s1074-7613(02)00454-5" @default.
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