Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149119305> ?p ?o ?g. }
- W2149119305 endingPage "269" @default.
- W2149119305 startingPage "255" @default.
- W2149119305 abstract "Mutations or duplications in MECP2 cause Rett and Rett-like syndromes, neurodevelopmental disorders characterized by mental retardation, motor dysfunction, and autistic behaviors. MeCP2 is expressed in many mammalian tissues and functions as a global repressor of transcription; however, the molecular mechanisms by which MeCP2 dysfunction leads to the neural-specific phenotypes of RTT remain poorly understood. Here, we show that neuronal activity and subsequent calcium influx trigger the de novo phosphorylation of MeCP2 at serine 421 (S421) by a CaMKII-dependent mechanism. MeCP2 S421 phosphorylation is induced selectively in the brain in response to physiological stimuli. Significantly, we find that S421 phosphorylation controls the ability of MeCP2 to regulate dendritic patterning, spine morphogenesis, and the activity-dependent induction of Bdnf transcription. These findings suggest that, by triggering MeCP2 phosphorylation, neuronal activity regulates a program of gene expression that mediates nervous system maturation and that disruption of this process in individuals with mutations in MeCP2 may underlie the neural-specific pathology of RTT." @default.
- W2149119305 created "2016-06-24" @default.
- W2149119305 creator A5002722949 @default.
- W2149119305 creator A5009529380 @default.
- W2149119305 creator A5012234077 @default.
- W2149119305 creator A5013503446 @default.
- W2149119305 creator A5014989628 @default.
- W2149119305 creator A5015350202 @default.
- W2149119305 creator A5026255018 @default.
- W2149119305 creator A5041802063 @default.
- W2149119305 creator A5055063428 @default.
- W2149119305 creator A5064036628 @default.
- W2149119305 creator A5068099853 @default.
- W2149119305 creator A5073462259 @default.
- W2149119305 creator A5083695993 @default.
- W2149119305 creator A5090813306 @default.
- W2149119305 date "2006-10-01" @default.
- W2149119305 modified "2023-10-12" @default.
- W2149119305 title "Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation" @default.
- W2149119305 cites W1488115555 @default.
- W2149119305 cites W1559742681 @default.
- W2149119305 cites W1584917605 @default.
- W2149119305 cites W1963806203 @default.
- W2149119305 cites W1964159332 @default.
- W2149119305 cites W1970355769 @default.
- W2149119305 cites W1974814280 @default.
- W2149119305 cites W1974950833 @default.
- W2149119305 cites W1975791071 @default.
- W2149119305 cites W1976444641 @default.
- W2149119305 cites W1979305117 @default.
- W2149119305 cites W1981495424 @default.
- W2149119305 cites W1986936425 @default.
- W2149119305 cites W1989053030 @default.
- W2149119305 cites W1989576874 @default.
- W2149119305 cites W1991979408 @default.
- W2149119305 cites W1993852989 @default.
- W2149119305 cites W1998977808 @default.
- W2149119305 cites W2000313340 @default.
- W2149119305 cites W2001621733 @default.
- W2149119305 cites W2001657520 @default.
- W2149119305 cites W2015748323 @default.
- W2149119305 cites W2021235911 @default.
- W2149119305 cites W2033609439 @default.
- W2149119305 cites W2035090622 @default.
- W2149119305 cites W2037174767 @default.
- W2149119305 cites W2040914733 @default.
- W2149119305 cites W2063840478 @default.
- W2149119305 cites W2064226140 @default.
- W2149119305 cites W2065857393 @default.
- W2149119305 cites W2067004457 @default.
- W2149119305 cites W2074698464 @default.
- W2149119305 cites W2079054696 @default.
- W2149119305 cites W2081070804 @default.
- W2149119305 cites W2083673419 @default.
- W2149119305 cites W2085710872 @default.
- W2149119305 cites W2092879602 @default.
- W2149119305 cites W2094544368 @default.
- W2149119305 cites W2105815383 @default.
- W2149119305 cites W2108470366 @default.
- W2149119305 cites W2110442840 @default.
- W2149119305 cites W2115301408 @default.
- W2149119305 cites W2124683806 @default.
- W2149119305 cites W2125603023 @default.
- W2149119305 cites W2127311839 @default.
- W2149119305 cites W2140493425 @default.
- W2149119305 cites W2146831587 @default.
- W2149119305 cites W2152497434 @default.
- W2149119305 cites W2153810829 @default.
- W2149119305 cites W2155388782 @default.
- W2149119305 cites W2166052438 @default.
- W2149119305 cites W2170078281 @default.
- W2149119305 cites W2171657985 @default.
- W2149119305 cites W38110762 @default.
- W2149119305 doi "https://doi.org/10.1016/j.neuron.2006.09.037" @default.
- W2149119305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3962021" @default.
- W2149119305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17046689" @default.
- W2149119305 hasPublicationYear "2006" @default.
- W2149119305 type Work @default.
- W2149119305 sameAs 2149119305 @default.
- W2149119305 citedByCount "763" @default.
- W2149119305 countsByYear W21491193052012 @default.
- W2149119305 countsByYear W21491193052013 @default.
- W2149119305 countsByYear W21491193052014 @default.
- W2149119305 countsByYear W21491193052015 @default.
- W2149119305 countsByYear W21491193052016 @default.
- W2149119305 countsByYear W21491193052017 @default.
- W2149119305 countsByYear W21491193052018 @default.
- W2149119305 countsByYear W21491193052019 @default.
- W2149119305 countsByYear W21491193052020 @default.
- W2149119305 countsByYear W21491193052021 @default.
- W2149119305 countsByYear W21491193052022 @default.
- W2149119305 countsByYear W21491193052023 @default.
- W2149119305 crossrefType "journal-article" @default.
- W2149119305 hasAuthorship W2149119305A5002722949 @default.
- W2149119305 hasAuthorship W2149119305A5009529380 @default.
- W2149119305 hasAuthorship W2149119305A5012234077 @default.
- W2149119305 hasAuthorship W2149119305A5013503446 @default.
- W2149119305 hasAuthorship W2149119305A5014989628 @default.