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• W2149120477 abstract "Female reproductive hormones control mammary gland morphogenesis. In the absence of the progesterone receptor (PR) from the mammary epithelium, ductal side-branching fails to occur. We can overcome this defect by ectopic expression of the protooncogene Wnt-1 . Transplantation of mammary epithelia from Wnt-4 − / − mice shows that Wnt-4 has an essential role in side-branching early in pregnancy. PR and Wnt-4 mRNAs colocalize to the luminal compartment of the ductal epithelium. Progesterone induces Wnt-4 in mammary epithelial cells and is required for increased Wnt-4 expression during pregnancy. Thus, Wnt signaling is essential in mediating progesterone function during mammary gland morphogenesis." @default.
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• W2149120477 date "2000-03-15" @default.
• W2149120477 modified "2023-10-10" @default.
• W2149120477 title "Essential function of <i>Wnt-4</i> in mammary gland development downstream of progesterone signaling" @default.
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• W2149120477 doi "https://doi.org/10.1101/gad.14.6.650" @default.
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