FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149125881> ?p ?o ?g. }

• W2149125881 endingPage "528" @default.
• W2149125881 startingPage "521" @default.
• W2149125881 abstract "Trypanotolerance is the capacity of certain West-African, taurine breeds of cattle to remain productive and gain weight after trypanosome infection. Laboratory studies, comparing Trypanosoma congolense infections in trypanotolerant N'Dama cattle (Bos taurus) and in more susceptible Boran cattle (Bos indicus), confirmed the field observations. Experiments using haemopoietic chimeric twins, composed of a tolerant and a susceptible co-twin, and T cell depletion studies suggested that trypanotolerance is composed of two independent traits. The first is a better capacity to control parasitaemia and is not mediated by haemopoietic cells, T lymphocytes or antibodies. The second is a better capacity to limit anaemia development and is mediated by haemopoietic cells, but not by T lymphocytes or antibodies. Weight gain was linked to the latter mechanism, implying that anaemia control is more important for survival and productivity than parasite control. Anemia is a marker for a more complex pathology which resembles human haemophagocytic syndrome: hepatosplenomegaly, pancytopenia and a large number of hyperactivated phagocytosing macrophages in bone marrow, liver and other tissues. Thus, mortality and morbidity in trypanosome-infected cattle are primarily due to self-inflicted damage by disproportionate immune and/or innate responses. These features of bovine trypanotolerance differ greatly from those in murine models. In mice, resistance is a matter of trypanosome control dependent on acquired immunity. However, a model of anaemia development can be established using C57BL/6J mice. As in cattle, the induction of anaemia was independent of T cells but its development differed with different trypanosome strains. Identification of the molecular pathways that lead to anaemia and haemophagocytosis should allow us to design new strategies to control disease." @default.
• W2149125881 created "2016-06-24" @default.
• W2149125881 creator A5021152526 @default.
• W2149125881 date "2006-05-01" @default.
• W2149125881 modified "2023-09-25" @default.
• W2149125881 title "Bovine trypanotolerance: A natural ability to prevent severe anaemia and haemophagocytic syndrome?" @default.
• W2149125881 cites W1727423433 @default.
• W2149125881 cites W1851322102 @default.
• W2149125881 cites W1919522310 @default.
• W2149125881 cites W1968475648 @default.
• W2149125881 cites W1970925929 @default.
• W2149125881 cites W1971919332 @default.
• W2149125881 cites W1984666982 @default.
• W2149125881 cites W1990443993 @default.
• W2149125881 cites W2002664550 @default.
• W2149125881 cites W2002721890 @default.
• W2149125881 cites W2009170144 @default.
• W2149125881 cites W2013338470 @default.
• W2149125881 cites W2014783012 @default.
• W2149125881 cites W2016328179 @default.
• W2149125881 cites W2017443971 @default.
• W2149125881 cites W2018699585 @default.
• W2149125881 cites W2019158277 @default.
• W2149125881 cites W2034601931 @default.
• W2149125881 cites W2035264210 @default.
• W2149125881 cites W2038136964 @default.
• W2149125881 cites W2038452442 @default.
• W2149125881 cites W2038798354 @default.
• W2149125881 cites W2038855250 @default.
• W2149125881 cites W2038986367 @default.
• W2149125881 cites W2039123417 @default.
• W2149125881 cites W2039703634 @default.
• W2149125881 cites W2039895914 @default.
• W2149125881 cites W2040353336 @default.
• W2149125881 cites W2042408915 @default.
• W2149125881 cites W2044101774 @default.
• W2149125881 cites W2044126895 @default.
• W2149125881 cites W2047755796 @default.
• W2149125881 cites W2052672736 @default.
• W2149125881 cites W2052819487 @default.
• W2149125881 cites W2054545601 @default.
• W2149125881 cites W2054660283 @default.
• W2149125881 cites W2064915342 @default.
• W2149125881 cites W2075174985 @default.
• W2149125881 cites W2075256793 @default.
• W2149125881 cites W2080266624 @default.
• W2149125881 cites W2081842562 @default.
• W2149125881 cites W2082420522 @default.
• W2149125881 cites W2085133751 @default.
• W2149125881 cites W2086050192 @default.
• W2149125881 cites W2086912914 @default.
• W2149125881 cites W2089074931 @default.
• W2149125881 cites W2091000683 @default.
• W2149125881 cites W2091324106 @default.
• W2149125881 cites W2110008404 @default.
• W2149125881 cites W2111232882 @default.
• W2149125881 cites W2114927499 @default.
• W2149125881 cites W2119230889 @default.
• W2149125881 cites W2123061584 @default.
• W2149125881 cites W2123402671 @default.
• W2149125881 cites W2123628257 @default.
• W2149125881 cites W2127004470 @default.
• W2149125881 cites W2127081185 @default.
• W2149125881 cites W2127278509 @default.
• W2149125881 cites W2128408768 @default.
• W2149125881 cites W2128741022 @default.
• W2149125881 cites W2137239273 @default.
• W2149125881 cites W2143773760 @default.
• W2149125881 cites W2145323130 @default.
• W2149125881 cites W2146690134 @default.
• W2149125881 cites W2167422517 @default.
• W2149125881 cites W2170679901 @default.
• W2149125881 cites W2460770227 @default.
• W2149125881 cites W272552125 @default.
• W2149125881 cites W4255069614 @default.
• W2149125881 cites W75719839 @default.
• W2149125881 doi "https://doi.org/10.1016/j.ijpara.2006.02.012" @default.
• W2149125881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16678182" @default.
• W2149125881 hasPublicationYear "2006" @default.
• W2149125881 type Work @default.
• W2149125881 sameAs 2149125881 @default.
• W2149125881 citedByCount "141" @default.
• W2149125881 countsByYear W21491258812012 @default.
• W2149125881 countsByYear W21491258812013 @default.
• W2149125881 countsByYear W21491258812014 @default.
• W2149125881 countsByYear W21491258812015 @default.
• W2149125881 countsByYear W21491258812016 @default.
• W2149125881 countsByYear W21491258812017 @default.
• W2149125881 countsByYear W21491258812018 @default.
• W2149125881 countsByYear W21491258812019 @default.
• W2149125881 countsByYear W21491258812020 @default.
• W2149125881 countsByYear W21491258812021 @default.
• W2149125881 countsByYear W21491258812022 @default.
• W2149125881 countsByYear W21491258812023 @default.
• W2149125881 crossrefType "journal-article" @default.
• W2149125881 hasAuthorship W2149125881A5021152526 @default.
• W2149125881 hasConcept C159047783 @default.
• W2149125881 hasConcept C159654299 @default.

• next