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- W2149128081 abstract "Dynamin-related protein 1 (DRP1) plays an important role in mitochondrial fission at steady state and during apoptosis. Using fluorescence recovery after photobleaching, we demonstrate that in healthy cells, yellow fluorescent protein (YFP)-DRP1 recycles between the cytoplasm and mitochondria with a half-time of 50 s. Strikingly, during apoptotic cell death, YFP-DRP1 undergoes a transition from rapid recycling to stable membrane association. The rapid cycling phase that characterizes the early stages of apoptosis is independent of Bax/Bak. However, after Bax recruitment to the mitochondrial membranes but before the loss of mitochondrial membrane potential, YFP-DRP1 becomes locked on the membrane, resulting in undetectable fluorescence recovery. This second phase in DRP1 cycling is dependent on the presence of Bax/Bak but independent of hFis1 and mitochondrial fragmentation. Coincident with Bax activation, we detect a Bax/Bak-dependent stimulation of small ubiquitin-like modifier-1 conjugation to DRP1, a modification that correlates with the stable association of DRP1 with mitochondrial membranes. Altogether, these data demonstrate that the apoptotic machinery regulates the biochemical properties of DRP1 during cell death." @default.
- W2149128081 created "2016-06-24" @default.
- W2149128081 creator A5054555574 @default.
- W2149128081 creator A5070050490 @default.
- W2149128081 creator A5074688125 @default.
- W2149128081 date "2007-04-30" @default.
- W2149128081 modified "2023-10-17" @default.
- W2149128081 title "Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death" @default.
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- W2149128081 doi "https://doi.org/10.1083/jcb.200610042" @default.
- W2149128081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2064824" @default.
- W2149128081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17470634" @default.
- W2149128081 hasPublicationYear "2007" @default.
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