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- W2149128264 abstract "Leukemias/lymphomas with IGH-involving del(14q)(1) commonly lose the DLK1-GTL2 imprinted domain that comprises several paternally and maternally expressed genes, including a cluster of microRNAs. Given that deletion of this region could lead to inactivation of a monoallelically expressed tumor suppressor gene, our study aimed at determination of the parental origin of del(14q/IGH). The designed allele-specific methylation study of the DLK1/GTL2 intergenic differentially methylated region allowed us to determine the parental origin of del(14q/IGH) in 9/20 analyzed cases. In six cases del(14q/IGH) was of the paternal origin and in three cases of the maternal origin. These findings argue against the concept that a TSG/anti-oncomir located in the imprinted region is systematically inactivated by a targeted deletion of its functional allele." @default.
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- W2149128264 date "2009-10-01" @default.
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- W2149128264 title "Methylation analysis of the imprinted<i>DLK1-GTL2</i>domain supports the random parental origin of the<i>IGH</i>-involving del(14q) in B-cell malignancies" @default.
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- W2149128264 doi "https://doi.org/10.4161/epi.4.7.9924" @default.
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