Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149128483> ?p ?o ?g. }
- W2149128483 endingPage "375" @default.
- W2149128483 startingPage "367" @default.
- W2149128483 abstract "MRE11/RAD50/NBS1 (MRN) is a ubiquitous complex that participates in the response to DNA damage and in immunoglobulin (Ig) gene diversification. Ig gene diversification is initiated by deamination of cytosine to uracil, followed by removal of uracil to create an abasic (AP) site. We find that MRE11 associates specifically with rearranged Ig genes in hypermutating B cells, whereas APE1, the major AP-endonuclease in faithful base excision repair, does not. We show that purified, recombinant MRE11/RAD50 can cleave DNA at AP sites and that this AP-lyase activity is conserved from humans to Archaea. MRE11/RAD50 cleaves at AP sites within single-stranded regions of DNA, suggesting that at transcribed Ig genes, cleavage may be coordinated with deamination by AID and deglycosylation by UNG2 to produce single-strand breaks (SSBs) that undergo subsequent mutagenic repair and recombination. These results identify MRN with DNA cleavage in the AID-initiated pathway of Ig gene diversification." @default.
- W2149128483 created "2016-06-24" @default.
- W2149128483 creator A5040073830 @default.
- W2149128483 creator A5077685901 @default.
- W2149128483 creator A5077775297 @default.
- W2149128483 creator A5088715864 @default.
- W2149128483 date "2005-11-01" @default.
- W2149128483 modified "2023-09-27" @default.
- W2149128483 title "MRE11/RAD50 Cleaves DNA in the AID/UNG-Dependent Pathway of Immunoglobulin Gene Diversification" @default.
- W2149128483 cites W1575498014 @default.
- W2149128483 cites W1599617947 @default.
- W2149128483 cites W1954469784 @default.
- W2149128483 cites W1966200086 @default.
- W2149128483 cites W1966355086 @default.
- W2149128483 cites W1968950713 @default.
- W2149128483 cites W1980898330 @default.
- W2149128483 cites W1981213575 @default.
- W2149128483 cites W1983700730 @default.
- W2149128483 cites W1985264665 @default.
- W2149128483 cites W1987600396 @default.
- W2149128483 cites W2002043709 @default.
- W2149128483 cites W2012648382 @default.
- W2149128483 cites W2016165485 @default.
- W2149128483 cites W2026414367 @default.
- W2149128483 cites W2027083790 @default.
- W2149128483 cites W2028025897 @default.
- W2149128483 cites W2029864255 @default.
- W2149128483 cites W2034622045 @default.
- W2149128483 cites W2036806870 @default.
- W2149128483 cites W2039669092 @default.
- W2149128483 cites W2043252165 @default.
- W2149128483 cites W2045816796 @default.
- W2149128483 cites W2047852652 @default.
- W2149128483 cites W2054123861 @default.
- W2149128483 cites W2064194162 @default.
- W2149128483 cites W2072326976 @default.
- W2149128483 cites W2072877304 @default.
- W2149128483 cites W2073622904 @default.
- W2149128483 cites W2077008254 @default.
- W2149128483 cites W2082234447 @default.
- W2149128483 cites W2082981258 @default.
- W2149128483 cites W2087678694 @default.
- W2149128483 cites W2087753682 @default.
- W2149128483 cites W2089721587 @default.
- W2149128483 cites W2094094914 @default.
- W2149128483 cites W2097432692 @default.
- W2149128483 cites W2097997319 @default.
- W2149128483 cites W2100736164 @default.
- W2149128483 cites W2107408311 @default.
- W2149128483 cites W2110394056 @default.
- W2149128483 cites W2125489655 @default.
- W2149128483 cites W2133076002 @default.
- W2149128483 cites W2133566539 @default.
- W2149128483 cites W2133895526 @default.
- W2149128483 cites W2137189278 @default.
- W2149128483 cites W2138938081 @default.
- W2149128483 cites W2140038303 @default.
- W2149128483 cites W2143049545 @default.
- W2149128483 cites W2145157145 @default.
- W2149128483 cites W2148731561 @default.
- W2149128483 cites W2151606470 @default.
- W2149128483 cites W2157935839 @default.
- W2149128483 cites W2159076267 @default.
- W2149128483 cites W2165608602 @default.
- W2149128483 cites W2170122994 @default.
- W2149128483 doi "https://doi.org/10.1016/j.molcel.2005.09.018" @default.
- W2149128483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16285919" @default.
- W2149128483 hasPublicationYear "2005" @default.
- W2149128483 type Work @default.
- W2149128483 sameAs 2149128483 @default.
- W2149128483 citedByCount "73" @default.
- W2149128483 countsByYear W21491284832012 @default.
- W2149128483 countsByYear W21491284832013 @default.
- W2149128483 countsByYear W21491284832014 @default.
- W2149128483 countsByYear W21491284832016 @default.
- W2149128483 countsByYear W21491284832017 @default.
- W2149128483 countsByYear W21491284832018 @default.
- W2149128483 countsByYear W21491284832020 @default.
- W2149128483 countsByYear W21491284832021 @default.
- W2149128483 crossrefType "journal-article" @default.
- W2149128483 hasAuthorship W2149128483A5040073830 @default.
- W2149128483 hasAuthorship W2149128483A5077685901 @default.
- W2149128483 hasAuthorship W2149128483A5077775297 @default.
- W2149128483 hasAuthorship W2149128483A5088715864 @default.
- W2149128483 hasBestOaLocation W21491284831 @default.
- W2149128483 hasConcept C104317684 @default.
- W2149128483 hasConcept C128526571 @default.
- W2149128483 hasConcept C134935766 @default.
- W2149128483 hasConcept C145782189 @default.
- W2149128483 hasConcept C150777479 @default.
- W2149128483 hasConcept C153911025 @default.
- W2149128483 hasConcept C159654299 @default.
- W2149128483 hasConcept C181199279 @default.
- W2149128483 hasConcept C187206112 @default.
- W2149128483 hasConcept C192396546 @default.
- W2149128483 hasConcept C2775984157 @default.
- W2149128483 hasConcept C2776985229 @default.
- W2149128483 hasConcept C2778453870 @default.