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- W2149129145 abstract "The traditional view in the field of epithelial transport has been to look upon the chloride ion as the obedient passive partner that follows the actively transported Na+ ion. This view has to be modified or even rejected for several epithelia, including different nephron segments. In this volume, Schild et al examine the mechanisms of proximal tubule chloride transport. My contribu tion briefly summarizes the mechanisms of chloride transport in distal nephron segments. In the reabsorptive processes the Clion generally takes the transcellular route rather than that between cell. To cross the cell, the Cl ion must penetrate the luminal and basolateral cell membranes. In different distal tubular segments various carrier systems and ion channels are responsi ble for chloride permeation. Much progress has been made recently in the understanding of the mech anism of NaCl reabsorption in the thick acending limb of the loop of Henle (13, 29). Our knowledge about the mechanisms responsible for NaCl reabsorption in the early distal tubule (19) is much less extensive. With respect to research on the collecting tubule, rapid progress has been made since intracellular microelectrode technology has been applied to the various segments and functionally heterogenous cell types (35, 45, 48). In the collect ing tubule, Cltransport is closely related to bicarbonate transport. This specific transport proc'ess is covered in this volume by Luke & Galla. The" @default.
- W2149129145 created "2016-06-24" @default.
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- W2149129145 date "1988-10-01" @default.
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- W2149129145 title "Chloride Transport in Thick Ascending Limb, Distal Convolution, and Collecting Duct" @default.
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- W2149129145 doi "https://doi.org/10.1146/annurev.ph.50.030188.000551" @default.
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