FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149132356> ?p ?o ?g. }

• W2149132356 endingPage "181" @default.
• W2149132356 startingPage "172" @default.
• W2149132356 abstract "Although growing evidence from trials and population-based studies has supported a protective role for flavonoids in relation to risk of certain chronic diseases, the underlying mechanisms remain unclear. Several previous studies focused on individual inflammatory biomarkers, but because of the limited specificity of any individual marker, an assessment of a combination of biomarkers may be more informative.We used an inflammation score (IS) that integrated 12 individual inflammatory biomarkers for the examination of associations with intakes of different flavonoid classes.The study was a cross-sectional analysis of 2375 Framingham Heart Study Offspring Cohort participants. Intakes of total flavonoids and their classes (anthocyanins, flavonols, flavanones, flavan-3-ols, polymers, and flavones) were calculated from validated food-frequency questionnaires. Individual inflammatory biomarkers were ranked, standardized, and summed to derive an overall IS and subgroup scores of functionally related biomarkers.In multivariate analyses, an inverse association between higher anthocyanin and flavonol intakes and IS was observed with a mean ± SE difference between quintile categories 5 and 1 of -1.48 ± 0.32 (P-trend ≤ 0.001) and -0.72 ± 0.33 (P-trend = 0.01), respectively. Results remained significant after additional adjustment for physical activity and vitamin C and fruit and vegetable intakes. Higher anthocyanin intake was inversely associated with all biomarker subgroups, whereas higher flavonol intake was associated only with lower cytokine and oxidative stress biomarker concentrations. In food-based analyses, higher intakes of apples and pears, red wine, and strawberries were associated with a lower IS with differences between quintiles 5 and 1 of -1.02 ± 0.43 (P = 0.006), -1.73 ± 0.39 (P < 0.001), and -0.44 ± 0.88 (P = 0.02), respectively. Although intakes of other classes were not associated with a reduction in overall IS, higher intakes of flavan-3-ols and their polymers were associated with a significant reduction in oxidative stress biomarkers.These findings provide evidence to suggest that an anti-inflammatory effect may be a key component underlying the reduction in risk of certain chronic diseases associated with higher intakes of anthocyanins and flavonols. The Framingham Offspring Study was registered at clinicaltrials.gov as NCT00005121 (Framingham Heart Study)." @default.
• W2149132356 created "2016-06-24" @default.
• W2149132356 creator A5000353299 @default.
• W2149132356 creator A5049560816 @default.
• W2149132356 creator A5061491005 @default.
• W2149132356 creator A5064192696 @default.
• W2149132356 creator A5078716241 @default.
• W2149132356 creator A5081960485 @default.
• W2149132356 date "2015-07-01" @default.
• W2149132356 modified "2023-10-15" @default.
• W2149132356 title "Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults" @default.
• W2149132356 cites W1608308125 @default.
• W2149132356 cites W1684832135 @default.
• W2149132356 cites W1964373857 @default.
• W2149132356 cites W1971061678 @default.
• W2149132356 cites W1977122148 @default.
• W2149132356 cites W1978039741 @default.
• W2149132356 cites W1993360693 @default.
• W2149132356 cites W1993430834 @default.
• W2149132356 cites W2000054651 @default.
• W2149132356 cites W2001227329 @default.
• W2149132356 cites W2036399835 @default.
• W2149132356 cites W2041911313 @default.
• W2149132356 cites W2042503457 @default.
• W2149132356 cites W2044205944 @default.
• W2149132356 cites W2047416413 @default.
• W2149132356 cites W2048746173 @default.
• W2149132356 cites W2055603793 @default.
• W2149132356 cites W2060580528 @default.
• W2149132356 cites W2066523855 @default.
• W2149132356 cites W2068629868 @default.
• W2149132356 cites W2071385669 @default.
• W2149132356 cites W2092394124 @default.
• W2149132356 cites W2098565557 @default.
• W2149132356 cites W2102160308 @default.
• W2149132356 cites W2104761334 @default.
• W2149132356 cites W2108909778 @default.
• W2149132356 cites W2111082589 @default.
• W2149132356 cites W2111335747 @default.
• W2149132356 cites W2112216880 @default.
• W2149132356 cites W2113605815 @default.
• W2149132356 cites W2121005650 @default.
• W2149132356 cites W2124162221 @default.
• W2149132356 cites W2125632278 @default.
• W2149132356 cites W2129761592 @default.
• W2149132356 cites W2130393481 @default.
• W2149132356 cites W2130495917 @default.
• W2149132356 cites W2134634767 @default.
• W2149132356 cites W2134920988 @default.
• W2149132356 cites W2137777229 @default.
• W2149132356 cites W2138657506 @default.
• W2149132356 cites W2142700037 @default.
• W2149132356 cites W2151975547 @default.
• W2149132356 cites W2152127469 @default.
• W2149132356 cites W2152153752 @default.
• W2149132356 cites W2168582474 @default.
• W2149132356 cites W2171102147 @default.
• W2149132356 doi "https://doi.org/10.3945/ajcn.115.108555" @default.
• W2149132356 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4480670" @default.
• W2149132356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26016863" @default.
• W2149132356 hasPublicationYear "2015" @default.
• W2149132356 type Work @default.
• W2149132356 sameAs 2149132356 @default.
• W2149132356 citedByCount "139" @default.
• W2149132356 countsByYear W21491323562015 @default.
• W2149132356 countsByYear W21491323562016 @default.
• W2149132356 countsByYear W21491323562017 @default.
• W2149132356 countsByYear W21491323562018 @default.
• W2149132356 countsByYear W21491323562019 @default.
• W2149132356 countsByYear W21491323562020 @default.
• W2149132356 countsByYear W21491323562021 @default.
• W2149132356 countsByYear W21491323562022 @default.
• W2149132356 countsByYear W21491323562023 @default.
• W2149132356 crossrefType "journal-article" @default.
• W2149132356 hasAuthorship W2149132356A5000353299 @default.
• W2149132356 hasAuthorship W2149132356A5049560816 @default.
• W2149132356 hasAuthorship W2149132356A5061491005 @default.
• W2149132356 hasAuthorship W2149132356A5064192696 @default.
• W2149132356 hasAuthorship W2149132356A5078716241 @default.
• W2149132356 hasAuthorship W2149132356A5081960485 @default.
• W2149132356 hasBestOaLocation W21491323561 @default.
• W2149132356 hasConcept C126322002 @default.
• W2149132356 hasConcept C204452808 @default.
• W2149132356 hasConcept C2776292868 @default.
• W2149132356 hasConcept C2778004101 @default.
• W2149132356 hasConcept C2778945092 @default.
• W2149132356 hasConcept C2779054382 @default.
• W2149132356 hasConcept C2779106036 @default.
• W2149132356 hasConcept C2781197716 @default.
• W2149132356 hasConcept C2908647359 @default.
• W2149132356 hasConcept C31903555 @default.
• W2149132356 hasConcept C42407357 @default.
• W2149132356 hasConcept C55493867 @default.
• W2149132356 hasConcept C59822182 @default.
• W2149132356 hasConcept C71924100 @default.
• W2149132356 hasConcept C72563966 @default.
• W2149132356 hasConcept C86803240 @default.
• W2149132356 hasConcept C99454951 @default.

• next