Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149133589> ?p ?o ?g. }
- W2149133589 abstract "In the last 50 years, only one drug has achieved marketing approval for treatment of systemic lupus erythematosus (SLE) by global regulatory authorities. This drug, belimumab, is a monoclonal antibody that binds to and inhibits BAFF. Blisibimod is a ‘peptibody’ consisting of four BAFF-binding domains fused to the Fc domain of human IgG1, and is structurally distinct from the anti-BAFF monoclonal antibodies such as belimumab and tabalumab. Compared with tabalumab and belimumab, blisibimod's binding affinity for BAFF (1 pM) is 126–250-fold higher, while its serum half-life (8–10 days) is approximately half as long. Completed Phase I and Phase II clinical trials with blisibimod provide the first evidence that subcutaneous administration of a biologic therapeutic may lead to improvements in SLE disease activity, as well as disease-associated pharmacodynamic markers, including peripheral B cells, autoantibodies and decreased complement consumption. Furthermore, the effect to significantly decrease the urinary ..." @default.
- W2149133589 created "2016-06-24" @default.
- W2149133589 creator A5014847392 @default.
- W2149133589 creator A5024571354 @default.
- W2149133589 creator A5086018261 @default.
- W2149133589 date "2014-04-01" @default.
- W2149133589 modified "2023-09-22" @default.
- W2149133589 title "The potential role of blisibimod for the treatment of systemic lupus erythematosus" @default.
- W2149133589 cites W1524102446 @default.
- W2149133589 cites W1538768110 @default.
- W2149133589 cites W1625166229 @default.
- W2149133589 cites W1920115643 @default.
- W2149133589 cites W1975085076 @default.
- W2149133589 cites W1983378819 @default.
- W2149133589 cites W1989273660 @default.
- W2149133589 cites W1994649501 @default.
- W2149133589 cites W2000054082 @default.
- W2149133589 cites W2002823890 @default.
- W2149133589 cites W2003219520 @default.
- W2149133589 cites W2008925400 @default.
- W2149133589 cites W2018918678 @default.
- W2149133589 cites W2023982464 @default.
- W2149133589 cites W2024266233 @default.
- W2149133589 cites W20245227 @default.
- W2149133589 cites W2027014013 @default.
- W2149133589 cites W2027261088 @default.
- W2149133589 cites W2036095604 @default.
- W2149133589 cites W2046330020 @default.
- W2149133589 cites W2055338105 @default.
- W2149133589 cites W2057481842 @default.
- W2149133589 cites W2062909821 @default.
- W2149133589 cites W2064214572 @default.
- W2149133589 cites W2072086606 @default.
- W2149133589 cites W2076992868 @default.
- W2149133589 cites W2085579205 @default.
- W2149133589 cites W2090794714 @default.
- W2149133589 cites W2091468965 @default.
- W2149133589 cites W2093076036 @default.
- W2149133589 cites W2094445987 @default.
- W2149133589 cites W2096286605 @default.
- W2149133589 cites W2097165105 @default.
- W2149133589 cites W2102699037 @default.
- W2149133589 cites W2104769463 @default.
- W2149133589 cites W2106574491 @default.
- W2149133589 cites W2111416025 @default.
- W2149133589 cites W2116977142 @default.
- W2149133589 cites W2119296184 @default.
- W2149133589 cites W2125556789 @default.
- W2149133589 cites W2126846485 @default.
- W2149133589 cites W2131457901 @default.
- W2149133589 cites W2136149088 @default.
- W2149133589 cites W2137030991 @default.
- W2149133589 cites W2138906847 @default.
- W2149133589 cites W2148562391 @default.
- W2149133589 cites W2152853007 @default.
- W2149133589 cites W2157160440 @default.
- W2149133589 cites W2157487266 @default.
- W2149133589 cites W2159860846 @default.
- W2149133589 cites W2161537704 @default.
- W2149133589 cites W2163404524 @default.
- W2149133589 cites W2167736693 @default.
- W2149133589 cites W2320195601 @default.
- W2149133589 cites W2323638726 @default.
- W2149133589 cites W2327976102 @default.
- W2149133589 cites W2516356673 @default.
- W2149133589 cites W35403735 @default.
- W2149133589 doi "https://doi.org/10.2217/ijr.14.7" @default.
- W2149133589 hasPublicationYear "2014" @default.
- W2149133589 type Work @default.
- W2149133589 sameAs 2149133589 @default.
- W2149133589 citedByCount "2" @default.
- W2149133589 countsByYear W21491335892016 @default.
- W2149133589 crossrefType "journal-article" @default.
- W2149133589 hasAuthorship W2149133589A5014847392 @default.
- W2149133589 hasAuthorship W2149133589A5024571354 @default.
- W2149133589 hasAuthorship W2149133589A5086018261 @default.
- W2149133589 hasConcept C126322002 @default.
- W2149133589 hasConcept C159654299 @default.
- W2149133589 hasConcept C163764329 @default.
- W2149133589 hasConcept C163864487 @default.
- W2149133589 hasConcept C170286685 @default.
- W2149133589 hasConcept C203014093 @default.
- W2149133589 hasConcept C2775915377 @default.
- W2149133589 hasConcept C2776912625 @default.
- W2149133589 hasConcept C2778453870 @default.
- W2149133589 hasConcept C2779134260 @default.
- W2149133589 hasConcept C2780035454 @default.
- W2149133589 hasConcept C2781205201 @default.
- W2149133589 hasConcept C535046627 @default.
- W2149133589 hasConcept C542903549 @default.
- W2149133589 hasConcept C71924100 @default.
- W2149133589 hasConcept C98274493 @default.
- W2149133589 hasConceptScore W2149133589C126322002 @default.
- W2149133589 hasConceptScore W2149133589C159654299 @default.
- W2149133589 hasConceptScore W2149133589C163764329 @default.
- W2149133589 hasConceptScore W2149133589C163864487 @default.
- W2149133589 hasConceptScore W2149133589C170286685 @default.
- W2149133589 hasConceptScore W2149133589C203014093 @default.
- W2149133589 hasConceptScore W2149133589C2775915377 @default.
- W2149133589 hasConceptScore W2149133589C2776912625 @default.