Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149142116> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2149142116 endingPage "1178" @default.
- W2149142116 startingPage "1173" @default.
- W2149142116 abstract "Estradiol (E2) and testosterone (T) are biologically active hormones that serve as important diagnostic markers in serum of premenopausal and postmenopausal women and in men. These hormones are measured frequently by immunoassay in clinical laboratories and the test results are used in the diagnosis and treatment of patients. For measuring the hormones by immunoassay, most laboratories utilize commercially available reagents that are packaged in the form of a kit and are used either in an automated instrument or manually. However, both the diagnostic kit manufacturer and testing laboratory seldom thoroughly validate the assay methods generated with these kits. This deficiency may lead to unreliable test results that could affect clinical evaluation and treatment of patients. The purpose of the present study was to assess the reliability of immunoassays that quantify serum E2 and T levels with commercial diagnostic kits. The data generally show wide differences in the apparent levels of each hormone in a given sample obtained with kits from different manufacturers. This was especially true when measuring postmenopausal E2 and T levels. However, a purification step, which included organic solvent extraction, prior to radioimmunoassay (RIA) of E2 gave values that compared well with those obtained by conventional RIA (with preceding extraction/chromatographic steps). Our results point out the importance of more thoroughly validating assays performed with commercial immunoassay kits, especially with respect to sensitivity and specificity, prior to their use for measuring hormone levels in patient samples." @default.
- W2149142116 created "2016-06-24" @default.
- W2149142116 creator A5004446486 @default.
- W2149142116 creator A5017900438 @default.
- W2149142116 creator A5038514254 @default.
- W2149142116 creator A5038748341 @default.
- W2149142116 creator A5053540007 @default.
- W2149142116 creator A5068589255 @default.
- W2149142116 date "2003-12-01" @default.
- W2149142116 modified "2023-10-15" @default.
- W2149142116 title "Limitations of direct estradiol and testosterone immunoassay kits" @default.
- W2149142116 cites W1514783140 @default.
- W2149142116 cites W1580621471 @default.
- W2149142116 cites W1581985252 @default.
- W2149142116 cites W1919873909 @default.
- W2149142116 cites W1991837028 @default.
- W2149142116 cites W2026845568 @default.
- W2149142116 cites W2035462015 @default.
- W2149142116 cites W2076369526 @default.
- W2149142116 cites W2079098330 @default.
- W2149142116 cites W2105700464 @default.
- W2149142116 cites W2129944389 @default.
- W2149142116 cites W2272037979 @default.
- W2149142116 cites W3000669041 @default.
- W2149142116 doi "https://doi.org/10.1016/j.steroids.2003.08.012" @default.
- W2149142116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14643879" @default.
- W2149142116 hasPublicationYear "2003" @default.
- W2149142116 type Work @default.
- W2149142116 sameAs 2149142116 @default.
- W2149142116 citedByCount "175" @default.
- W2149142116 countsByYear W21491421162012 @default.
- W2149142116 countsByYear W21491421162013 @default.
- W2149142116 countsByYear W21491421162014 @default.
- W2149142116 countsByYear W21491421162015 @default.
- W2149142116 countsByYear W21491421162016 @default.
- W2149142116 countsByYear W21491421162017 @default.
- W2149142116 countsByYear W21491421162018 @default.
- W2149142116 countsByYear W21491421162019 @default.
- W2149142116 countsByYear W21491421162020 @default.
- W2149142116 countsByYear W21491421162021 @default.
- W2149142116 countsByYear W21491421162022 @default.
- W2149142116 countsByYear W21491421162023 @default.
- W2149142116 crossrefType "journal-article" @default.
- W2149142116 hasAuthorship W2149142116A5004446486 @default.
- W2149142116 hasAuthorship W2149142116A5017900438 @default.
- W2149142116 hasAuthorship W2149142116A5038514254 @default.
- W2149142116 hasAuthorship W2149142116A5038748341 @default.
- W2149142116 hasAuthorship W2149142116A5053540007 @default.
- W2149142116 hasAuthorship W2149142116A5068589255 @default.
- W2149142116 hasConcept C126322002 @default.
- W2149142116 hasConcept C159654299 @default.
- W2149142116 hasConcept C176685330 @default.
- W2149142116 hasConcept C185592680 @default.
- W2149142116 hasConcept C203014093 @default.
- W2149142116 hasConcept C2778656385 @default.
- W2149142116 hasConcept C2779279991 @default.
- W2149142116 hasConcept C2780420688 @default.
- W2149142116 hasConcept C43617362 @default.
- W2149142116 hasConcept C71315377 @default.
- W2149142116 hasConcept C71924100 @default.
- W2149142116 hasConceptScore W2149142116C126322002 @default.
- W2149142116 hasConceptScore W2149142116C159654299 @default.
- W2149142116 hasConceptScore W2149142116C176685330 @default.
- W2149142116 hasConceptScore W2149142116C185592680 @default.
- W2149142116 hasConceptScore W2149142116C203014093 @default.
- W2149142116 hasConceptScore W2149142116C2778656385 @default.
- W2149142116 hasConceptScore W2149142116C2779279991 @default.
- W2149142116 hasConceptScore W2149142116C2780420688 @default.
- W2149142116 hasConceptScore W2149142116C43617362 @default.
- W2149142116 hasConceptScore W2149142116C71315377 @default.
- W2149142116 hasConceptScore W2149142116C71924100 @default.
- W2149142116 hasIssue "14" @default.
- W2149142116 hasLocation W21491421161 @default.
- W2149142116 hasLocation W21491421162 @default.
- W2149142116 hasOpenAccess W2149142116 @default.
- W2149142116 hasPrimaryLocation W21491421161 @default.
- W2149142116 hasRelatedWork W1969688909 @default.
- W2149142116 hasRelatedWork W1994420353 @default.
- W2149142116 hasRelatedWork W2074815152 @default.
- W2149142116 hasRelatedWork W2079250078 @default.
- W2149142116 hasRelatedWork W2086774736 @default.
- W2149142116 hasRelatedWork W2154669946 @default.
- W2149142116 hasRelatedWork W2361602205 @default.
- W2149142116 hasRelatedWork W2383901644 @default.
- W2149142116 hasRelatedWork W2409870954 @default.
- W2149142116 hasRelatedWork W2412172118 @default.
- W2149142116 hasVolume "68" @default.
- W2149142116 isParatext "false" @default.
- W2149142116 isRetracted "false" @default.
- W2149142116 magId "2149142116" @default.
- W2149142116 workType "article" @default.