FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149142170> ?p ?o ?g. }

• W2149142170 endingPage "4419" @default.
• W2149142170 startingPage "4411" @default.
• W2149142170 abstract "The general amino acid permease, Gap1p, of Saccharomyces cerevisiae transports all naturally occurring amino acids into yeast cells for use as a nitrogen source. Previous studies have shown that a nonubiquitinateable form of the permease, Gap1p K9R,K16R , is constitutively localized to the plasma membrane. Here, we report that amino acid transport activity of Gap1p K9R,K16R can be rapidly and reversibly inactivated at the plasma membrane by the presence of amino acid mixtures. Surprisingly, we also find that addition of most single amino acids is lethal to Gap1p K9R,K16R -expressing cells, whereas mixtures of amino acids are less toxic. This toxicity appears to be the consequence of uptake of unusually large quantities of a single amino acid. Exploiting this toxicity, we isolated gap1 alleles deficient in transport of a subset of amino acids. Using these mutations, we show that Gap1p inactivation at the plasma membrane does not depend on the presence of either extracellular or intracellular amino acids, but does require active amino acid transport by Gap1p. Together, our findings uncover a new mechanism for inhibition of permease activity in response to elevated amino acid levels and provide a physiological explanation for the stringent regulation of Gap1p activity in response to amino acids." @default.
• W2149142170 created "2016-06-24" @default.
• W2149142170 creator A5023155290 @default.
• W2149142170 creator A5025868576 @default.
• W2149142170 creator A5033516887 @default.
• W2149142170 creator A5061082353 @default.
• W2149142170 date "2006-10-01" @default.
• W2149142170 modified "2023-10-01" @default.
• W2149142170 title "Activity-dependent Reversible Inactivation of the General Amino Acid Permease" @default.
• W2149142170 cites W1239298729 @default.
• W2149142170 cites W1538592956 @default.
• W2149142170 cites W1760420664 @default.
• W2149142170 cites W1808790922 @default.
• W2149142170 cites W1963888459 @default.
• W2149142170 cites W1981346241 @default.
• W2149142170 cites W1988904809 @default.
• W2149142170 cites W2011094024 @default.
• W2149142170 cites W2014176614 @default.
• W2149142170 cites W2018443770 @default.
• W2149142170 cites W2045776897 @default.
• W2149142170 cites W2046163489 @default.
• W2149142170 cites W2059775037 @default.
• W2149142170 cites W2065852288 @default.
• W2149142170 cites W2068268311 @default.
• W2149142170 cites W2080389783 @default.
• W2149142170 cites W2080442977 @default.
• W2149142170 cites W2081118837 @default.
• W2149142170 cites W2087883677 @default.
• W2149142170 cites W2109535551 @default.
• W2149142170 cites W2110166578 @default.
• W2149142170 cites W2110374270 @default.
• W2149142170 cites W2116986980 @default.
• W2149142170 cites W2134671651 @default.
• W2149142170 cites W2136816588 @default.
• W2149142170 cites W2139188448 @default.
• W2149142170 cites W2141475940 @default.
• W2149142170 cites W2143028392 @default.
• W2149142170 cites W2146375872 @default.
• W2149142170 cites W2146584158 @default.
• W2149142170 cites W2148960370 @default.
• W2149142170 cites W2159108936 @default.
• W2149142170 cites W2159368155 @default.
• W2149142170 cites W2160758120 @default.
• W2149142170 cites W2165601698 @default.
• W2149142170 cites W2168150036 @default.
• W2149142170 cites W2171231952 @default.
• W2149142170 cites W2343067289 @default.
• W2149142170 cites W4230073243 @default.
• W2149142170 cites W4237195626 @default.
• W2149142170 cites W4243741585 @default.
• W2149142170 doi "https://doi.org/10.1091/mbc.e06-06-0506" @default.
• W2149142170 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1635348" @default.
• W2149142170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16885415" @default.
• W2149142170 hasPublicationYear "2006" @default.
• W2149142170 type Work @default.
• W2149142170 sameAs 2149142170 @default.
• W2149142170 citedByCount "61" @default.
• W2149142170 countsByYear W21491421702012 @default.
• W2149142170 countsByYear W21491421702013 @default.
• W2149142170 countsByYear W21491421702014 @default.
• W2149142170 countsByYear W21491421702015 @default.
• W2149142170 countsByYear W21491421702016 @default.
• W2149142170 countsByYear W21491421702017 @default.
• W2149142170 countsByYear W21491421702018 @default.
• W2149142170 countsByYear W21491421702019 @default.
• W2149142170 countsByYear W21491421702020 @default.
• W2149142170 countsByYear W21491421702021 @default.
• W2149142170 countsByYear W21491421702022 @default.
• W2149142170 countsByYear W21491421702023 @default.
• W2149142170 crossrefType "journal-article" @default.
• W2149142170 hasAuthorship W2149142170A5023155290 @default.
• W2149142170 hasAuthorship W2149142170A5025868576 @default.
• W2149142170 hasAuthorship W2149142170A5033516887 @default.
• W2149142170 hasAuthorship W2149142170A5061082353 @default.
• W2149142170 hasBestOaLocation W21491421702 @default.
• W2149142170 hasConcept C104317684 @default.
• W2149142170 hasConcept C115335371 @default.
• W2149142170 hasConcept C149011108 @default.
• W2149142170 hasConcept C190114821 @default.
• W2149142170 hasConcept C2777576037 @default.
• W2149142170 hasConcept C2779222958 @default.
• W2149142170 hasConcept C28406088 @default.
• W2149142170 hasConcept C41625074 @default.
• W2149142170 hasConcept C515207424 @default.
• W2149142170 hasConcept C55493867 @default.
• W2149142170 hasConcept C57947595 @default.
• W2149142170 hasConcept C79879829 @default.
• W2149142170 hasConcept C86803240 @default.
• W2149142170 hasConceptScore W2149142170C104317684 @default.
• W2149142170 hasConceptScore W2149142170C115335371 @default.
• W2149142170 hasConceptScore W2149142170C149011108 @default.
• W2149142170 hasConceptScore W2149142170C190114821 @default.
• W2149142170 hasConceptScore W2149142170C2777576037 @default.
• W2149142170 hasConceptScore W2149142170C2779222958 @default.
• W2149142170 hasConceptScore W2149142170C28406088 @default.
• W2149142170 hasConceptScore W2149142170C41625074 @default.
• W2149142170 hasConceptScore W2149142170C515207424 @default.
• W2149142170 hasConceptScore W2149142170C55493867 @default.

• next